Muscle Deterioration News and Research

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Researchers suggest a potential therapeutic strategy for muscle loss associated with obesity

Obesity has been linked to skeletal muscle loss and deterioration. While M2 macrophages may play a role in regulating muscle function, the underlying mechanisms remain poorly understood.

4 Aug 2026

New ‘heart-on-a-chip’ to halt cardiac damage caused by Duchenne

Duchenne Parent Project Spain (DPPE) has launched the BEAT Project, a research initiative focused on one of the key challenges associated with Duchenne and Becker muscular dystrophies: progressive heart damage. Cardiomyopathy is the leading cause of death in patients with DMD.

7 May 2026

Study links ultra-processed food intake to poorer thigh muscle quality

A Radiology study of 615 adults at risk for knee osteoarthritis found that higher ultra-processed food intake was associated with greater fat infiltration in thigh muscles on MRI, a marker of poorer muscle quality. The association remained after adjustment for BMI, was stronger in models using abdominal circumference, and did not differ significantly by sex.

15 Apr 2026

Blocking a key cell pathway reduces muscle wasting in pancreatic cancer

Researchers at the University of Houston are pushing the boundaries of biomedical innovation with a discovery that could transform treatment for one of cancer's most devastating complications.

16 Dec 2025

Targeting the glycocalyx may offer a new approach to reduce frailty in older adults

A new research paper was published in Volume 17, Issue 9 of Aging-US on August 30, 2025, titled, "Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity."

14 Oct 2025

New molecule linked to muscle loss in people with type 2 diabetes

Researchers at Karolinska Institutet have discovered a previously unknown molecule that may explain why people with type 2 diabetes often suffer from muscle weakness and muscle loss - a condition that has a major impact on quality of life and overall health.

10 Jul 2025

Alzheimer’s blood biomarkers predict faster muscle strength loss in older adults

A large Swedish cohort study found that elevated blood biomarkers associated with Alzheimer’s disease—including p-tau217, p-tau181, neurofilament light chain, and GFAP—predict accelerated muscle strength decline over 12 years in dementia-free older adults. These findings suggest that early identification of Alzheimer’s-related biomarkers could help clinicians intervene sooner to prevent sarcopenia and related adverse outcomes in aging populations.

27 May 2025

Scientists pinpoint metabolic failure as the cause of muscle loss in aging

A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, suggesting it as a potential therapeutic target.

17 Feb 2025

Lithocholic acid enhances health and lifespan, mimicking calorie restriction

Lithocholic acid (LCA), a metabolite induced by calorie restriction (CR), activates AMPK and mimics anti-aging benefits. A recent study highlights LCA's role in improving muscle performance, glucose tolerance, and lifespan in aged organisms.

1 Jan 2025

Researchers identify drug with anti-aging effects

Aging is an inevitable phenomenon and is accompanied by several comorbidities. To this end, research into the effects of aging has become paramount, and scientists are looking for ways to slow down aging and its detrimental impact on the human body.

25 Sep 2024

First comprehensive atlas sheds new light on processes underlying age-related muscle changes

How muscle changes with aging, and tries to fight its effects, is now better understood at the cellular and molecular level with the first comprehensive atlas of aging muscles in humans.

15 Apr 2024

World-renowned menopause experts summarize the state of menopause knowledge and advocate for further research

In a recent review published in Cell, a group of authors delved into the complexities of menopause, assessed its global impacts on health, and evaluated the effectiveness and safety of current treatments, emphasizing the importance of further research.

6 Sep 2023

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

10 Mar 2022

Study finds early stages of sarcopenia could be counteracted with timely interventions

Weakening muscles are a natural part of the ageing process, but for some people with a condition called sarcopenia the decline is abnormally fast.

30 Nov 2021

Study shows higher risk of sarcopenia among older adults who are underweight and lack exercise

Analysis of medical data from around 1800 65-year-old residents of Kobe, a large Japanese city, has shown that at least 3% have possible sarcopenia (*1), revealing that the risks are higher in those who are underweight and don't exercise enough.

24 Aug 2021

FDA approval provides targeted treatment option for patients with rare DMD mutation

Today, the U.S. Food and Drug Administration granted approval for Amondys 45 (casimersen) injection for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping (Exons are pieces of DNA that provide information for making proteins in a person's genome).

25 Feb 2021

FDA approves new treatment option for patients with rare Duchenne muscular dystrophy mutation

Today, the U.S. Food and Drug Administration granted accelerated approval to Viltepso (viltolarsen) injection for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 53 skipping.

12 Aug 2020

Simple accelerometers improve diagnosis of Duchenne muscular dystrophy

Duchenne muscular dystrophy is the most common type of muscular dystrophy, affecting more than 10,000 males at birth per year in the United States with severe physical disability, chronic wasting and muscle deterioration.

11 Feb 2020

Carnegie biologists discover possible therapeutic target for slow healing of aged muscles

An age-related decline in recovery from muscle injury can be traced to a protein that suppresses the special ability of muscle stem cells to build new muscles, according to work from a team of current and former Carnegie biologists led by Chen-Ming Fan and published in Nature Metabolism.

30 Sep 2019

Physical activity may help fight depression in seniors

The benefits of exercise are widely known but kinesiologists at McMaster University have for the first time found that physical activity may help fight depression in seniors by stimulating muscle-generated mood boosters.

8 Feb 2019