Neuralgia News and Research

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Neuralgia is pain in one or more nerves that occurs without stimulation of pain receptor (nociceptor) cells. Neuralgia pain is produced by a change in neurological structure or function rather than by the excitation of pain receptors that causes nociceptive pain.

Novel salvage surgical approach for refractory multiple sclerosis-related trigeminal neuralgia

A case report in Chinese Neurosurgical Journal describes a novel salvage surgical approach for refractory multiple sclerosis-related trigeminal neuralgia.

16 Jul 2026

Varicella-zoster virus inflicts lasting damage to nerves and the brain, study reveals

For millions worldwide, herpes zoster pain does not end when the rash fades. Postherpetic neuralgia can last for years or even a lifetime, devastating quality of life.

26 Jun 2026

Molecular keyhole discovery offers new hope for personalized pain therapies

Researchers at VIB, VUB, and KU Leuven have identified a tiny binding site, a molecular 'keyhole', in the TRPM3 ion channel, a crucial sensor in pain signaling.

21 Apr 2026

Study identifies genetic fingerprint of neuropathic pain neurons

Researchers from The University of Texas at Dallas and their international colleagues have determined the molecular signature of human sleeping - or silent - nociceptors: sensory neurons that are unresponsive to touch or pressure yet are key culprits in neuropathic pain.

4 Feb 2026

Shingles vaccination may slow biological aging in older adults

Shingles vaccination not only protects against the disease but may also contribute to slower biological aging in older adults, according to a new USC Leonard Davis School of Gerontology study.

20 Jan 2026

New plant-derived therapy shows promise for cancer pain relief

RTX is a non-addictive pain therapy derived from a cactus-like plant.

29 May 2025

Promising results seen in atypical trigeminal neuralgia with combined surgical approach

Atypical trigeminal neuralgia (ATN) is a chronic pain condition characterized by persistent facial pain that does not respond well to conventional medical treatments, often leading to significant impairment in quality of life.

25 Apr 2025

Long-term low-dose antiviral treatment reduces eye disease risk from shingles

Long-term, low-dose antiviral treatment reduces the risk for potentially vision-damaging bouts of inflammation and infection, as well as pain, which occur when shingles affects the eye, according to new research presented October 19 at the annual meeting of the American Academy of Ophthalmology (AAO) in Chicago.

20 Oct 2024

New insights into pain mechanisms related to viral infections

An article published in the journal Brain, Behavior, and Immunity reports the findings of a study by researchers based in Brazil, the United States and South Korea who set out to understand how viral infections cause pain and to contribute to the search for novel ways of relieving it.

15 Oct 2024

Study paves way to more efficient non-addictive treatment for chronic pain

Researchers at Karolinska Institutet in Sweden have developed a new comprehensive mapping of genetic activity for understanding the causes of chronic pain.

4 Oct 2024

Light-activated drugs: A revolutionary approach in neuropathic pain treatment

Light can be used to activate drugs in specific parts of the body through photopharmacology.

11 Jul 2024

Inflation Reduction Act boosts shingles vaccine uptake by 46% for Medicare Part D recipients

Among the aims of the Inflation Reduction Act (IRA) is reducing health care costs for older adults by eliminating cost sharing for certain drugs and vaccines covered by Medicare Part D.

23 May 2024

Woman petitions health insurer after company approves — then rejects — her infusions

When KFF Health News published an article in August about the "prior authorization hell" Sally Nix said she went through to secure approval from her insurance company for the expensive monthly infusions she needs, we thought her story had a happy ending.

4 Jan 2024

Yale scientists identify drug target that may alleviate joint degeneration in osteoarthritis

Yale researchers have identified a drug target that may alleviate joint degeneration associated with osteoarthritis, a debilitating condition that afflicts as many as 30 million people in the United States alone, which they report on Jan. 3 in the journal Nature.

3 Jan 2024

Herpes zoster vaccination and healthy aging: Study connect the dots

Vaccination with recombinant zoster vaccine (RZV) prevents Herpes Zoster (HZ) infection.

30 Nov 2023

Live shingles vaccine highly effective in the first year after vaccination and then wanes substantially

The effectiveness of live zoster (shingles) vaccine is highest in the first year after vaccination and then wanes substantially.

8 Nov 2023

Exploring developmental pathways and disease interactions in nervous and stomatognathic systems

Scientists discuss the intricate relationship between the nervous and stomatognathic systems.

21 Aug 2023

Exploring the efficacy of topical lidocaine in individuals with chronic neck pain

A team of researchers investigated the efficacy of lidocaine for the treatment of neck pain.

17 Jul 2023

Study finds recent shingles infection increases the risk of myocardial infarction

Researchers assessed myocardial infarction (MI) risk after zoster infection.

30 Mar 2023

Shingles linked with higher long-term risk of major cardiovascular event

A new study by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, demonstrated that shingles, also known as herpes zoster, is associated with an almost 30% higher long-term risk of a major cardiovascular event such a stroke or heart attack.

22 Nov 2022