Nucleoside News and Research

RSS

AI speeds development of therapeutic hydrogels for gum disease

Periodontitis is one of the most common chronic inflammatory diseases worldwide and a leading cause of tooth loss in adults.

1 Jul 2026

H5N1 spreads through multiple routes on infected dairy farms

The H5N1 strain of highly pathogenic avian influenza H5N1 has been detected in over 700 herds of dairy cows in California, the largest dairy-producing state in the U.S.

5 May 2026

Hepatitis C drug may prevent hepatitis E virus replication

A drug that is already in clinical trials against hepatitis C virus can also prevent hepatitis E virus from replicating.

22 Mar 2026

RNA micelles enable targeted chemotherapy without immune toxicity

A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects.

7 Feb 2026

New oral antiretroviral shows potential as long-acting HIV pre-exposure prophylaxis

A new HIV antiretroviral shows promise as a long-acting, oral prophylactic agent, according to a new study by Izzat Raheem, Tracy Diamond and colleagues from Merck & Co., Inc., Rahway, NJ, USA, published August 26th in the open-access journal PLOS Biology.

26 Aug 2025

Tokyo researchers reveal key role of Fen1 in resisting antiviral and anticancer drug effects

Researchers from Tokyo Metropolitan University have discovered a new pathway by which cells counteract the action of alovudine, an important antiviral and anticancer drug.

10 Aug 2025

Scientists unlock potential of cytokine adjuvants in mRNA vaccines

In the quest to design vaccines that better help the body's immune system fight disease, scientists are always looking for more tools for their arsenal.

6 Jun 2025

Oral 8-aminoguanine protects aging eyes and preserves vision in preclinical study

Oral 8-aminoguanine (8-AG) treatment preserved retinal structure and rod function in aged Fischer 344 rats, significantly reducing oxidative stress and inflammation. These findings highlight the promise of 8-AG as a non-invasive intervention to slow age-related retinal degeneration.

27 May 2025

Affordable HIV drug shows promise in improving vision for diabetic eye disease

An inexpensive, long-approved HIV drug can improve vision in patients with a blinding complication of diabetes more effectively and a much lower cost than many existing treatments, an initial clinical trial suggests.

27 May 2025

HIV drugs found to significantly reduce Alzheimer's risk in new study

UVA Health scientists are calling for clinical trials testing the potential of HIV drugs called NRTIs to prevent Alzheimer's disease after discovering that patients taking the drugs are substantially less likely to develop the memory-robbing condition.

8 May 2025

Targeted polymersomes boost methotrexate efficacy for aggressive choriocarcinoma treatment

Researchers develop targeted polymersomes loaded with methotrexate for the treatment of gestational choriocarcinoma,

11 Feb 2025

New drug delivery system shows promise for treating choriocarcinoma

A new drug delivery system shows promise for treating a rare, aggressive form of cancer affecting pregnant women and new mothers, and it has potential with other cancers as well.

6 Feb 2025

Novel antibodies show promise for tumor targeting and RAD51 inhibition

A new research paper was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition."

21 Oct 2024

Cardiovascular risks of COVID-19 antivirals

Study reviews cardiovascular side effects linked to antiviral therapies for COVID-19, highlighting the need for careful consideration when prescribing these drugs to high-risk patients.

16 Sep 2024

New insights into modified nucleoside synthesis

The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis system.

19 Jul 2024

Key differences in RNA editing found between postmortem and living brain

Researchers examined the adenosine-to-inosine (A-to-I) nucleoside editing of postmortem and live prefrontal cortical tissues.

3 Jul 2024

Synergistic cytotoxicity in pancreatic cancer: HDAC, PARP inhibitors, and decitabine show promise

A new research paper was published in Oncotarget's Volume 15 on June 3, 2024, entitled, "Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy."

5 Jun 2024