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An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.

Cannabis use increases mortality risk in alcohol-associated hepatitis patients

People with alcohol-associated hepatitis are more likely to die from the disease if they use cannabis. A large multinational study just published in Alcohol: Clinical and Experimental Research is the first to identify active substance use, particularly cannabis use, by patients as an independent predictor of death in patients with alcohol-associated hepatitis.

9 Nov 2026

Retatrutide reduces knee pain and body weight in osteoarthritis patients

For people with painful knee osteoarthritis (OA) who are overweight or have obesity, everyday activities such as walking, climbing stairs and standing up from a chair can be difficult.

8 Nov 2026

Cannabis dominates youth hospital visits while alcohol impacts older adults

A large national study analyzing emergency department visits and hospitalizations related to alcohol or cannabis use across the U.S. has found diverging age patterns: Among people who presented to the hospital for a substance-related problem, cannabis was involved in the majority of visits by adolescents and young adults, while alcohol predominated among older adults.

4 Nov 2026

Autism diagnosis patterns change as psychiatric profiles shift across Europe

The medical profiles of adults diagnosed with autism have changed hugely since 2010, finds a study of medical records in the UK and Sweden, published in the online journal BMJ Mental Health.

3 Nov 2026

Reducing opioid medication during pregnancy may not ease neonatal opioid withdrawal syndrome

Pregnant patients receiving medication to treat opioid use disorder should not reduce their medication dose out of fear that it will worsen withdrawal symptoms in their newborns, according to a new study led by researchers at the University of Maryland School of Medicine (UMSOM).

30 Oct 2026

Opioid drop drives decline in drug-related heart infection hospitalizations

A new national study found that hospitalizations for serious heart infections associated with drug use are declining after years of increases, driven largely by a decrease in opioid-associated cases.

27 Oct 2026

Young mothers see rapid increase in substance-related emergency department visits

Emergency department (ED) visits for use of substances, especially opioids, amphetamines, and cannabis, by mothers with dependent children increased almost 5% a year, in contrast to an increase of almost 2% a year among females without children, according to a large study in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.260078.

26 Oct 2026

Presurgical sleep medications linked to less pain and anxiety after surgery

Improving sleep before surgery through the use of melatonin or Ambien (zolpidem) may ease presurgical anxiety, reduce pain after surgery, decrease opioid requirements and help patients recover better, according to an analysis of 25 years of research presented at the ANESTHESIOLOGY® 2026 annual meeting.

19 Oct 2026

Light-activated experimental opioid eliminates dangerous side effects

Opioid painkillers are some of the strongest analgesic medicines, but they are also the riskiest owing to a range of side effects, including addiction.

15 Oct 2026

Maternal opioid use in pregnancy linked to childhood hospitalizations

Children whose mothers received opioid prescriptions during pregnancy have a higher rate of hospital admission in childhood than unexposed children, including unexposed siblings, according to a new study published October 13th in the open access journal PLOS Medicine by Dong Keon Yon of Kyung Hee University College of Medicine, South Korea, and colleagues.

13 Oct 2026

Long-term opioid use does not improve chronic back pain outcomes

Taking opioids for years does not seem to improve pain and functioning in people with chronic back pain, according to a new Northwestern University study that compared 70 long-term opioid users to 70 similar patients not taking opioids.

6 Oct 2026

UC San Diego receives funding to establish the Polysubstance Addiction Research Center

Researchers from University of California San Diego have received a $12.6 million award from the National Institute on Drug Abuse (NIDA) to establish the Polysubstance Addiction Research Center (PARC), a multidisciplinary center designed to uncover the biological factors that contribute to addiction across multiple substances.

30 Sep 2026

Declining benzodiazepine use reflects more cautious medical prescribing practices

The number of benzodiazepine prescriptions like Xanax and Valium dispensed in the United States decreased over the past 10 years, potentially suggesting that doctors have become more cautious when prescribing these sedatives, according to Rutgers Health researchers.

30 Sep 2026

New slow-release drug delivery system provides weeks of pain-numbing anesthetic effects

Most local anesthetics used in medicine only last eight to 12 hours or a day tops. Now Boston Children's Hospital researchers have formulated a more effective slow-release injectable drug delivery system that achieved pain-numbing anesthetic effects lasting two to three weeks in rats compared to a commercial formulation lasting about four to eight hours.

23 Sep 2026

Understanding opioid risks can help prevent accidental overdoses

According to numbers calculated from the CDC, approximately 80,000 people died last year from a drug overdose, which represents about 21 deaths per 100,000 residents in the U.S. alone. Overdose deaths are preventable, and in most of the cases we see, they are completely accidental.

24 Aug 2026

Survey provides a comprehensive snapshot of youth mental health and drug use in Ontario

Findings from the 2025 Ontario Student Drug Use and Health Survey (OSDUHS) released today by the Centre for Addiction and Mental Health (CAMH) suggest that Ontario middle and high school students have rebounded from the heightened mental health challenges seen during and immediately following the COVID-19 pandemic.

24 Aug 2026