Osteoblast News and Research

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Researchers uncover molecular pathway controlling bone resorption and tooth eruption

RUNX2 is best known as a master transcription factor of osteoblast differentiation. Mutations in, or haploinsufficiency of RUNX2 cause CCD, a skeletal disorder characterized by delayed permanent tooth eruption, supernumerary teeth and clavicular defects.

30 Oct 2026

Younger postmenopausal women may not get enough calcium

A small Italian study examined whether women facing heightened bone-loss risks are getting enough calcium from their diets, with particular attention to breast cancer patients receiving endocrine therapy.

6 Oct 2026

$Vitamin B12 deficiency was linked to higher fracture hazard after 50$

Vitamin B12 deficiency was linked to higher fracture hazard after 50

A study links abnormal vitamin B12 levels to fracture risk, highlighting a complex relationship beyond simple deficiency in middle-aged and older adults.

2 Oct 2026

Prednisone may impair bone health in children with Duchenne muscular dystrophy

In a new study published in Scientific Reports, an international and multidisciplinary research team including Binghamton University researchers identified a set of blood proteins that may explain why the corticosteroid prednisone, although beneficial in treating Duchenne muscular dystrophy (DMD), can interfere with childhood growth and bone health.

4 Sep 2026

Blocking the Axl receptor may offer a new way to promote bone formation

Osteoporosis is one of the most common age-related bone diseases, affecting millions of people worldwide and increasing the risk of fractures, disability, and reduced quality of life.

28 Jul 2026

Plant polymer lignin shows promise for future bone regeneration

A new study reveals that lignin - a natural plant polymer - can be transformed into a bioactive material that promotes the formation of bone-like minerals while supporting the growth of bone-forming cells.

27 Jul 2026

Study links collagen peptides to improved bone health in runners

Collagen is a protein found in skin, hair, nails, tendons, cartilage, and bones. Our bodies naturally produce collagen using the foods we eat. But, in recent years, collagen peptides have gained popularity as a supplement to support joint, hair, skin, and gut health.

22 Jul 2026

Scientists identify key osteoblast protein that promotes bone formation

New study identifies CAR3 as a key osteoblast protein promoting collagen mineralization, bone formation, and skeletal regeneration.

26 Jun 2026

Scientists discover how vitamin K pathway regulates bone remodeling

Bone is continuously renewed through a process known as bone remodeling, in which osteoblasts (bone-forming cells) build new bone, while osteoclasts (bone-resorbing cells) remove older mineralized tissue.

21 May 2026

Restoring ADAR2 enzyme reduces metastatic spread in osteosarcoma

Osteosarcoma is the most common primary bone cancer in children, adolescents, and young adults. Although chemotherapy and surgery have improved survival for localized disease, outcomes remain poor when tumors spread to the lungs or return after treatment.

20 May 2026

Suppressing TGF-β signaling reactivates dormant bone cells to treat osteoporosis

Osteoporosis, a common skeletal disorder, is marked by reduced bone mass and deterioration of bone microarchitecture, making bones more porous and prone to fractures.

8 May 2026

Blocking TGF-beta may enhance osteoporosis bone regeneration therapies

A recent mouse model based study suggests that blocking TGF-β may improve osteoporosis treatment by helping quiescent osteoblasts in inactive bone surfaces return to an active state.

7 May 2026

BSO mimics anti-obesity effects without causing bone loss in mice

A new research paper was published in Volume 18 of Aging-US on March 2, 2026, titled "D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice."

13 Mar 2026

Hormone therapy reduces abnormal nerve growth in chronic back pain

Low back pain (LBP) is one of the most common health problems worldwide, affecting people of all ages and placing a heavy burden on healthcare systems. Many patients experience persistent discomfort that interferes with work, sleep, and daily activities.

4 Feb 2026

Maternal stress linked to earlier baby teeth

Children have 20 milk teeth, 10 in each jaw. This set of teeth is important for chewing and speaking, and helps to keep space open for the subsequent set of 32 permanent teeth.

18 Nov 2025

New insights into pathogenic T cells offer hope for Crohn's disease treatment

The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.

4 Sep 2025

PEPITEM shows promise in treating osteoporosis by enhancing bone health

Researchers from the University of Birmingham, U.K., have identified bioactive peptide sequences in PEPITEM molecule, and demonstrated the biological of activity of the full PEPITEM molecule in counteracting key changes caused by osteoporosis.

2 Sep 2025

New insights into bone remodeling process in orthodontic tooth movement under hypoxia

Sustained hypoxia affects orthodontic tooth movement (OTM) by altering osteoclast and osteoblast differentiation, report researchers from Institute of Science Tokyo, Japan.

25 Aug 2025

Curcumin activates SIRT3 to protect bone structure in diabetic mice

In a new Scientific Reports study, curcumin protected bone-forming cells from high-glucose damage by activating the SIRT3/FoxO3a/NRF2 antioxidant pathway and restoring mitochondrial health. In diabetic mice, curcumin improved bone density and oxidative balance, highlighting its potential in osteoporosis prevention.

13 Aug 2025

High-dose vitamin D strengthens bones in very low birth weight infants

Research indicates that high-dose vitamin D improves bone health in very low birth weight preterm infants, highlighting its role in early development.

8 Aug 2025