Single Nucleotide Polymorphism News and Research

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Pediatric rheumatic diseases have unique genetic architecture compared to adults

Researchers from Children's Hospital of Philadelphia (CHOP) have found that pediatric-onset rheumatic and inflammatory diseases have distinct genetic architecture compared with adults.

12 Aug 2026

Scientists uncover 53 genetic clues that shape math ability beyond IQ

Researchers uncovered 53 genetic loci linked to quantitative ability, distinguishing it from general intelligence and non-cognitive skills. The study highlights brain pathways in axon guidance, synaptic signaling, and mRNA splicing as biological underpinnings of math-related ability.

22 Sep 2025

Genetic study shows dual GIPR/GLP1R action curbs binge alcohol use

Researchers used drug-target Mendelian randomization to test whether genetically proxied activation of GLP1R and GIPR influences alcohol-related behaviors. They found that GIPR, especially when combined with GLP1R, was linked to lower binge and heavy drinking, healthier food preferences, improved liver markers, and reduced coronary artery disease risk.

15 Sep 2025

Why Salmonella Dublin poses a food safety threat in beef and dairy

The study on Salmonella Dublin highlights its genomic similarities and resistance traits, raising concerns for food safety and antimicrobial resistance.

27 Aug 2025

HOXB13 emerges as a context-dependent regulator in cancer biology

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer.

5 Aug 2025

When old diseases find new ways in: Europe’s latest diphtheria outbreak explained

A large multicountry outbreak of toxigenic Corynebacterium diphtheriae occurred among migrants entering Europe in 2022, driven primarily by cutaneous infections and involving multiple genetic lineages. Despite the unprecedented surge, transmission to resident populations was limited, but rising antimicrobial resistance and delayed treatment highlight ongoing public health risks.

10 Jun 2025

Genetic variation found to influence tumor microbiota and colorectal cancer progression

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. While scientists believe that gut microbiota play an important role in both the onset and progression of CRC, emerging evidence points to the significance of intratumoral microbiota-microbiota inside tumors-in CRC progression.

29 Apr 2025

Light-induced DNA detection technique enables rapid, ultra-sensitive genetic analysis

PCR genetic analysis has been in the spotlight since COVID-19, but light is now further facilitating PCR-free methods.

22 Apr 2025

Gut bacteria and blood metabolites directly affect children’s height, study finds

Researchers used Mendelian randomization to uncover causal links between gut microbiota, blood metabolites, and short stature in children.

7 Apr 2025

Targeting miR-4274 and PEX5 can help overcome radioresistance in colorectal cancer

Colorectal cancer (CRC) is a global health concern, and despite advances in radiotherapy, endogenous radioresistance in CRC patients remains a challenge.

9 Jan 2025

Twigstats unveils Europe’s hidden ancestral shifts from Iron Age to Viking era

Twigstats reveals ancient migrations in Europe, enhancing genomic analysis and uncovering genetic shifts from 500 BCE to 1000 CE with unprecedented precision.

3 Jan 2025

Genomic conservation in Thailand's mangroves

In this interview, Wirulda Pootakham, the Director of Thailand's National Omic Centre, talks to NewsMedical about genomic conservation in Thailand's mangroves.

From MGI 6 Dec 2024

Minority genetic variation in tuberculosis offers new insights for improving outbreak tracking

Findings show that within-host MTBC variation improves transmission inference, suggesting new strategies for understanding and controlling tuberculosis spread.

2 Dec 2024

Study connects brain volume variations with genetic risk factors for Parkinson’s disease and ADHD

Unprecedented genome analysis reveals genetic links between brain structure and disorders like Parkinson's and ADHD, paving the way for innovative treatments.

23 Oct 2024

Study uncovers biological drivers of plasma proteins, offering new insights for disease biomarkers and drug discovery

Researchers mapped the biological influences on 4,775 plasma proteins, revealing the interplay of modifiable and non-modifiable factors, with key implications for disease biomarkers and drug targets.

30 Sep 2024

New gene variants linked to early menopause and cancer risk identified

Study reveals nine gene variants linked to ovarian aging and cancer risk, with implications for reproductive longevity and de novo mutation rates.

12 Sep 2024

Study reveals genetic link between Alzheimer's disease, lipid metabolism, and coronary artery disease

The genetic overlap between Alzheimer's disease (AD) (a neurodegenerative disorder causing memory loss and cognitive decline), lipid profiles, and coronary artery disease (CAD).

20 Aug 2024

Are personality traits linked to psychiatric disorders? Genome-wide study reveals genetic connections

Researchers identified 208 significant loci for neuroticism, revealing complex genetic influences on personality traits and their links to psychiatric conditions like depression and anxiety.

13 Aug 2024

Prenatal BPA exposure tied to autism risk in boys

Study reveals that prenatal exposure to BPA disrupts aromatase activity in male brains, potentially leading to autism-like symptoms. Treatment with 10-HDA shows promise in reversing these effects.

11 Aug 2024

AI reveals genetic links in aging, chronic diseases, and lifestyle factors across nine organ systems

Research uncovers how genetic factors influence the biological age of different organ systems, revealing their connections to lifestyle, chronic diseases, and potential therapeutic interventions.

5 Aug 2024