Neuropathic Pain News and Research

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Neuropathic pain is a type of pain that is caused by damage to the nervous system following an injury or illness and affects approximately 1% of the population.

Novel peptide approach reduces chronic neuropathic pain in mice

Understanding and treating chronic neuropathic pain has remained challenging due to its complex nature. New research from the lab of Clifford Woolf, MB, BCh, PhD, at Boston Children's Hospital's FM Kirby Neurobiology Center describes a novel approach for reducing pain by disrupting interactions within pain-sensing nerve cells called nociceptors

6 Oct 2026

GLP-1 drugs may influence chronic pain through gut-brain and immune pathways

Researchers reviewed evidence linking GLP-1 and GLP-1 receptor agonists to chronic pain modulation through gut microbial, neuroimmune, vagal, and metabolic pathways, with the strongest clinical evidence currently involving knee osteoarthritis and idiopathic intracranial hypertension headache. Much of the proposed biology remains supported by preclinical research, and human studies have yet to establish that GLP-1RA-induced changes in the gut microbiome directly cause pain relief.

24 Sep 2026

C-Path awards $1.7 million to advance five drug development projects

Critical Path Institute (C-Path) today announced that its Translational Therapeutics Accelerator has awarded $1,699,500 through five Bridging Research and Innovation in Drug Development Grants (BRIDGe).

22 Sep 2026

Targeted antibody therapy provides long-lasting relief from neuropathic pain

Pain is a natural protective mechanism that alerts the body to actual or potential injury. But when nerves themselves are damaged, they can generate abnormal pain signals even in the absence of a new injury.

16 Sep 2026

Discovery of calcium channel mechanism offers clues for brain disorder treatments

DGIST (President Kunwoo Lee) announced that a research team led by Professor Byung Chang Suh of the Department of Brain Sciences has, for the first time, uncovered a novel molecular mechanism that regulates the "N-type voltage-gated calcium channel (CaV2.2)," which plays a critical role in neural signal transmission.

29 Jul 2026

AI platform uncovers promising target for chronic pain treatmen

Despite the widespread availability of analgesics, pain management remains one of the most significant and pervasive challenges in modern medicine, with more than 20% of the global population suffering from chronic pain, especially chronic neuropathic pain characterized by central sensitization.

22 Jul 2026

Electroacupuncture relieves neuropathic pain and anxiety by activating specific brain circuit

Neuropathic pain affects nearly 10% of the global population, and up to 60% of those individuals also struggle with anxiety or other mood disorders.

24 Jun 2026

Study shows how HIV leads to chronic pain

Over half of the people carrying HIV experience chronic pain at some point, which is difficult to treat. In a new JNeurosci paper, Hui-Lin Pan, from The University of Texas MD Anderson Cancer Center, and colleagues used mice to explore how HIV leads to chronic pain.

1 Jun 2026

Psilocybin may provide long-lasting relief from chronic nerve pain

A single dose of psilocybin - the active compound in magic mushrooms - reduces nerve pain for up to a month and makes a widely used painkiller work more effectively, University of Reading research has found.

22 May 2026

NIH awards $3.9 million grant to develop a non-opioid pain treatment

The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH), has awarded a $3.9 million grant to a multi-institutional team led by scientists at Sanford Burnham Prebys Medical Discovery Institute to develop a non-opioid pain therapeutic and advance it into a Phase 1 clinical trial.

4 May 2026

Breakthrough technology decodes leg movement signals from nerves in amputees

A research team led by researchers at Chalmers University of Technology in Sweden, has, for the first time, successfully decoded leg movements directly from the remaining nerves in people with above-knee amputations.

19 Mar 2026

UCF researcher explores insulin signaling as new target for diabetic neuropathy

Neuropathy – chronic pain, numbness and tingling in the hands and feet – is a challenging fact of life for many patients with Type 1 diabetes.

2 Mar 2026

Electroacupuncture relieves pain-induced anxiety through prefrontal neural circuits

Neuropathic pain, caused by injury or disease of the somatosensory nervous system, is a major clinical challenge and often evolves into a chronic condition.

7 Feb 2026

Study identifies genetic fingerprint of neuropathic pain neurons

Researchers from The University of Texas at Dallas and their international colleagues have determined the molecular signature of human sleeping - or silent - nociceptors: sensory neurons that are unresponsive to touch or pressure yet are key culprits in neuropathic pain.

4 Feb 2026

Molecular signature of sleeping nociceptors offers new pain targets

Researchers from the Centre for Addiction and Mental Health (CAMH) and the Institute of Neurophysiology at Uniklinik RWTH Aachen in Germany have deciphered the molecular signature of so-called sleeping nociceptors-a type of pain-sensing nerve cell that normally remains quiet and does not respond to touch or pressure, but can become overactive and drive chronic pain.

4 Feb 2026

Dr Adam Davenport appointed as CSO to strengthen leadership in integrated drug discovery

We are pleased to announce the appointment of Dr Adam Davenport as Chief Scientific Officer to spearhead our integrated drug discovery offering for biotech and pharmaceutical partners.

From Concept Life Sciences 19 Jan 2026

Stimulating immune cells could offer new treatment for nerve injury pain

Researchers at The University of Texas MD Anderson Cancer Center have discovered that targeting a specific immune process could help improve recovery after nerve injury and reduce chronic pain.

7 Jan 2026

SN101 iPSC-derived therapy relieves chronic pain and preserves joints

SereNeuro Therapeutics, a preclinical biotechnology company developing non-opioid pain therapies, unveiled new data today on a novel approach to chronic pain management and joint tissue preservation.

12 Dec 2025

Study reveals the effectiveness of Painimation in decoding pain for sickle cell patients

Pain is a constant, complex companion that clinicians often struggle to understand and measure for people living with sickle cell disease. Traditional pain scales reduce this deeply personal experience to a single number that is often inaccurate.

13 Nov 2025

New NIH grants fuel research in oral cancer treatment and pain relief

Researchers at the School of Dentistry at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, have been awarded three multi-year grants totaling $6 million from the National Institutes of Health to address treatment and pain management for oral cancer.

7 Nov 2025