Chromatography News and Research

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Chromatography in Greek means to ‘write with colors.’ It is a versatile separation technique developed in 1903 by Mikhail Tswett, a Russian botanist. He separated colorful plant pigments using a column of calcium carbonate. Ever since its discovery, chromatography has evolved as a powerful tool in the lab for the separation and identification of different compounds in a mixture.

Dutch scientists unveil the integral role of CD5L protein in IgM structure and function

Researchers in the Netherlands assessed the structure of human circulatory IgM and its relationship with the small CD5L protein.

31 May 2023

Investigating the interplay between white blood cell count and incidence of hyper-low-density lipoprotein cholesterolemia

Researchers investigating the association between white blood cell count and LDL hypercholesteremia.

24 May 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Unlocking gut health: How indoor environment impacts the microbiota balance

Research paper highlights the importance of a diverse and balanced gut microbiota for human health, while emphasizing the need for further understanding of the impact of indoor microbiome and metabolites on gut microbiota.

21 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

Next-Generation EV Separation: Izon Science and Agarose Bead Technologies Collaborate to Enhance Clinical Applications for Extracellular Vesicles

A collaborative agreement between Izon Science and Agarose Bead Technologies (ABT) offers exceptional opportunities to develop solutions that aid in advancing EV research into clinical settings.

From Agarose Bead Technologies 16 May 2023

SARS-CoV-2 variants show altered glycan processing

Researchers examine spike-protein trimers from SARS-CoV-2 variants to compare the N (asparagine)-glycan landscape.

15 May 2023

Novel ingestible device enables non-invasive profiling of the gut microbiome, proteome, and metabolome

Researchers developed an ingestible device to collect samples from the human intestine.

12 May 2023

A machine-learning approach for the early diagnosis of Parkinson's disease

Scientists discuss a machine learning-based tool that can detect Parkinson's disease years before the first onset of symptoms.

11 May 2023

Leaves of the Labrador tea plant contain an essential oil that could help combat malaria

Much of what is now considered modern medicine originated as folk remedies or traditional, Indigenous practices. These customs are still alive today, and they could help address a variety of conditions.

11 May 2023

Laboratory instrument manufacturer from berlin honored with vorsprung award at the chancellor's office

On May 9, 2023, the VORSPRUNG Business Award, an accolade of the East German Business Forum OWF, was presented in Berlin at the Federal Chancellery.

From KNAUER Wissenschaftliche Geräte GmbH 11 May 2023

High-fat diets' eye-opening impact: Study reveals link to retinal damage and bisretinoid accumulation

In this study, the effects of a high-fat diet on the formation of bisretinoids in photoreceptor cells were explored. The results showed that mice on a high-fat diet had increased levels of bisretinoids and retinol-binding protein 4, which are associated with metabolic dysregulation.

8 May 2023

The dynamics and interactions between the skin metabolome, microbiome, and UV exposure

Researchers evaluated metabolic profile changes of the skin in relation to microbiota and UV exposure.

5 May 2023

Evaluating the association between Mediterranean Diet adherence and type 2 diabetes using nutritional biomarkers

Researchers developed a method for objective assessment of the effect Mediterranean Diet on T2D.

1 May 2023

Uncovering the interplay between (poly)phenol intake and cardiometabolic health

Researchers aimed to understand the relationship between (poly)phenol consumption and cardiometabolic health.

28 Apr 2023

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

27 Apr 2023

Low vitamin D levels during pregnancy linked to childhood obesity in boys

Study examines the association between prenatal vitamin D levels and growth and adiposity in late childhood. The results suggest a sex-specific programming effect of early pregnancy vitamin D3 levels on offspring body composition into late childhood observed in boys.

25 Apr 2023

Acylceramides and protein-bound ceramides are vital for the formation of oral barrier in mice

Acylceramides and protein-bound ceramides are vital for the formation of the oral barrier in mice, similar to their role in skin, protecting from infection.

12 Apr 2023