Severe Acute Respiratory News and Research

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Living with children does not increase adults’ risk of severe COVID-19, say researchers

Researchers working on behalf of NHS England have found no evidence that adults who live with school-age children are at any increased risk of severe outcomes following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

4 Nov 2020

Delirium accompanied by fever could be an early symptom of COVID-19

Delirium accompanied by fever could bean early symptom of COVID-19. This is the main conclusion drawn by a scientific research review carried out by researchers from the Universitat Oberta de Catalunya.

4 Nov 2020

Discoverey of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376

A team of scientists from the United States has recently revealed that small molecule inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease exhibit potent antiviral activity. These inhibitors show better efficacy when used in combination with antiviral medicine Remdesivir. The study is currently available on the bioRxiv* preprint server.

3 Nov 2020

Most SARS-CoV-2-infected individuals develop durable B cell-mediated immunity

Researchers from the Johns Hopkins University and The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA, investigated the durability of B cell immunity following SARS-CoV-2 infection and recovery in their recent work published on the preprint server medRxiv.

3 Nov 2020

Evidence of robust and persistent antibodies against SARS-CoV-2

A team of researchers from the Icahn School of Medicine at Mount Sinai, New York, have worked in collaboration to try and answer one of the most baffling questions surrounding the coronavirus disease 19 (COVID-19) pandemic: do antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) last after a primary infection?

3 Nov 2020

SARS-CoV-2 mutations becoming more contagious

A team of researchers working with Scott Wesley Long from Houston Methodist Hospital and colleagues from Texas, New York, and Illinois studied the patterns of genetic mutations of SARS CoV-2 and its impact on the second wave of infections worldwide.

3 Nov 2020

SARS-CoV-2 T-cell immunity is retained for at least six months

Now, a new study published on the preprint server bioRxiv shows that functional SARS-CoV-2-specific T-cell responses are retained for six months following infection. However, the strength of this response depends on the clinical features of the primary infection.

3 Nov 2020

SARS-CoV-2 attack rates among household contacts higher than among non-household contacts

Now, a team of researchers at the National Centre for Infectious Diseases in Singapore aimed to determine the transmission risk factors of SARS-CoV-2 among household and non-household contacts.

3 Nov 2020

AI speech processing framework detects inaudible COVID-19 cough

Now, a team of researchers at the Massachusetts Institute of Technology (MIT) has found that asymptomatic people may differ from those who are healthy in the way they cough. The differences are inaudible to the human ear but can be detected by artificial intelligence (AI).

3 Nov 2020

16 new lineages of SARS-CoV-2 emerge in South Africa despite lockdown

Published in a recent medRxiv* paper, researchers from South Africa, the United Kingdom, and Brazil found that these mutations in SARS-CoV-2 lineages are localized to South Africa. These unique strains, not found elsewhere in the world, are thought to have contributed around 42% to the country's total infection rate.

3 Nov 2020

Adaptive evolution of human coronaviruses may necessitate frequent reformulation of vaccines

Researchers from the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center, USA, have revealed that adaptive evolution in the antigenic regions facilitates seasonal coronaviruses to escape the host immune responses and to cause recurrent infections.

3 Nov 2020

Rapid generation of divergent synthetic antibodies against SARS-CoV-2 in a cell-free engineering platform

In a groundbreaking bioRxiv paper, a research group from the Massachusetts Institute of Technology (MIT), Harvard University and Howard Hughes Medical Institute in the US engineered antibodies against the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein by using a novel approach. In doing so, they also identified more than 800 predicted binder families.

3 Nov 2020

Re-thinking advance care planning during COVID-19 pandemic

Researchers in the UK have warned that healthcare professionals and providers need to consider how Advance Care Planning (ACP) can be resourced and normalized as part of standard care during the current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ahead of recurrent or future waves.

3 Nov 2020

Remdesivir metabolite GS-441524 inhibits SARS CoV-2 in mouse model, finds study

This new study titled, "Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model," was released online as a preprint on the bioRxiv* server, prior to undergoing the peer-review process.

2 Nov 2020

Only 56 percent of people intend to have free flu vaccination in the U.K. amid COVID

Now, a team of researchers at Keele University and Public Health England aimed to determine how many residents in the U.K. intend to get flu shots amid the COVID-19 pandemic. The researchers found that 55.8 percent of people intended to have the vaccination.

2 Nov 2020

Children with asthma having fewer attacks amid the coronavirus pandemic, study says

During the coronavirus disease (COVID-19) pandemic, an international team of researchers has found that children with asthma experienced fewer upper respiratory tract infections, emergency visits, fever episodes, asthma attacks, and hospital admissions compared with the previous year.

2 Nov 2020

Global collaboration provides a COVID-19 disease map

A collaboration of researchers from 120 different institutes across 30 countries including France, Germany, Australia, Japan, USA, India, Turkey, Brazil, and Canada initiated an effort to develop a COVID-19 Disease Map - a collection of computational models and diagrams of molecular mechanisms implicated in COVID-19.

2 Nov 2020

SARS-CoV-2 spike D614G variant exhibits enhanced replication and transmissibility

A team of scientists from Switzerland, Germany, and the USA has demonstrated that the S-614G variant can easily bind to the human angiotensin-converting enzyme 2 (ACE2), the cellular gateway of SARS-CoV-2. The variant also showed enhanced replication and transmissibility in animal models.

2 Nov 2020

Research finds detectable but low-level SARS-CoV-2 contamination on public surfaces

A team of researchers at Tufts University found that 8.3 percent of surface samples tested positive for SARS-CoV-2, including crosswalk buttons, trash can handles, and door handles of essential business entrances such as grocery stores, banks, gas stations, and liquor stores.

2 Nov 2020

Is it safe to resume cruise operations? CDC issues safety guidelines

Nearly a year into the coronavirus disease (COVID-19) pandemic, many countries are easing restrictions to rebuild their economies. At the same time, many industries are trying to return to a new normal, one of which being the cruise sector. Prior to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19, the cruise industry represented 2% of the worldwide travel and tourism industry.

2 Nov 2020

Severe Acute Respiratory News and Research

Living with children does not increase adults’ risk of severe COVID-19, say researchers

Delirium accompanied by fever could be an early symptom of COVID-19

Discoverey of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376

Most SARS-CoV-2-infected individuals develop durable B cell-mediated immunity

Evidence of robust and persistent antibodies against SARS-CoV-2

SARS-CoV-2 mutations becoming more contagious

SARS-CoV-2 T-cell immunity is retained for at least six months

SARS-CoV-2 attack rates among household contacts higher than among non-household contacts

AI speech processing framework detects inaudible COVID-19 cough

16 new lineages of SARS-CoV-2 emerge in South Africa despite lockdown

Adaptive evolution of human coronaviruses may necessitate frequent reformulation of vaccines

Rapid generation of divergent synthetic antibodies against SARS-CoV-2 in a cell-free engineering platform

Re-thinking advance care planning during COVID-19 pandemic

Remdesivir metabolite GS-441524 inhibits SARS CoV-2 in mouse model, finds study

Only 56 percent of people intend to have free flu vaccination in the U.K. amid COVID

Children with asthma having fewer attacks amid the coronavirus pandemic, study says

Global collaboration provides a COVID-19 disease map

SARS-CoV-2 spike D614G variant exhibits enhanced replication and transmissibility

Research finds detectable but low-level SARS-CoV-2 contamination on public surfaces

Is it safe to resume cruise operations? CDC issues safety guidelines

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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