Structural Protein News and Research

RSS

A modified protein mediates development of lung fibrosis after cadmium/carbon black exposure

The triggers and causes of a severe scarring disease of the lungs -- idiopathic pulmonary fibrosis, or IPF -- remain unclear.

18 Mar 2021

SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment, study finds

Researchers have found that SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment. Therefore, strategies such as focusing on limiting the production of IFN, rather than its function, could restrict the mechanism of SARS-CoV-2 that increases its viral load with delayed or absent symptoms.

12 Mar 2021

Proteomics shows SARS-CoV-2 NSP7 and NSP8 forms stable dimeric unit

A new preprint, released on the bioRxiv* preprint server, describes the structure of part of the dynamic protein-RNA complex known as the replication-transcription complex (RTC), which is crucial in the replication of the large ribonucleic acid (RNA) genome of this virus.

9 Mar 2021

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

A new paper in the journal Life presents an early review of the viral factors involved in initiating and effecting apoptosis within infected cells.

8 Mar 2021

Study provides different characteristics of COVID-19

The Coronavirus Disease 2019 (COVID-19) pandemic has affected almost every part of the globe with millions of cases and over a million deaths.

27 Feb 2021

COVID-19 may alter host proteins to cause autoimmunity

To better understand the transient and chronic autoimmune symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, researchers from Memorial Sloan Kettering Cancer Center, Guizhou Medical University, and biotech company Curandis embarked on an endeavor to establish a comprehensive autoantigenome for COVID19.

23 Feb 2021

GSK-3 inhibitors show promise in treating coronavirus infections

Researchers in the United States have suggested a new approach to treating infection with coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

23 Feb 2021

L452R mutation potentially favors adaptive evolution of SARS-CoV-2

A team of scientists from the United States recently investigated the mutational signatures in the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein.

23 Feb 2021

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

The study began with the generation of recombinant (r)SA11 rotaviruses, into which segment 7 modified RNAs were introduced. These encoded sequences for the non-structural protein NSP3 and some parts of the viral spike.

23 Feb 2021

Viral protein delivery system could facilitate COVID-19 research

Researchers in the United States have successfully delivered a critical structural protein found in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to a human cell line and tracked its localization deep within the cells.

22 Feb 2021

Researchers explain SARS-CoV-2's replication-transcription complex

The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still spreading rapidly throughout the world. A new preprint on the bioRxiv* server describes the structure of an important viral non-structural protein NSP12-16 and its role in SARS-CoV-2 infection.

22 Feb 2021

SARS-CoV-2 nucleoprotein increases infectivity of spike-based pseudoviruses

In a recent study conducted at the Indian Institute of Science Education and Research, India, a team of scientists screened specific genes of SARS-CoV-2 to identify factors that may contribute to viral infectivity.

17 Feb 2021

New SARS-CoV-2 variant found in newborn child with seizures in the United States

Researchers at a hospital in Washington D.C. found a new mutant strain of the virus in a neonatal patient with high viral loads. According to the authors, this strain could be spreading in the United States mid-Atlantic population and needs monitoring.

11 Feb 2021

SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), is associated with several clinical features common in autoimmune diseases as myalgias, arthralgias, fatigue, and rashes. COVID-19 patients also exhibit less common autoimmunity manifestations such as myositis, thrombosis, myocarditis, encephalitis, vasculitis, and arthritis.

1 Feb 2021

E484K mutation is potentially associated with SARS-CoV-2 adaptive fitness

A team of Brazilian scientists has recently conducted genomic and phylogenetic analyses of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome to understand the viral evolution process better. Their analyses reveal that the E484K mutated variant of SARS-CoV-2 is present in three different lineages in four Brazilian regions and that the mutation may serve as a common solution for viral evolution.

31 Jan 2021

Codon frequency optimization shows SARS-CoV-2 antiviral potential

A study conducted by researchers in the US has revealed that optimization of codon for bacterial expression causes the production of an inactive enzyme non-structural protein 12 (Nsp12), a catalytic subunit of RNA-dependent RNA polymerase of SARS-CoV-2.

26 Jan 2021

Researchers discover antibody that blocks the spread of dengue virus

A team of researchers led by the University of California, Berkeley and the University of Michigan has discovered an antibody that blocks the spread within the body of the dengue virus, a mosquito-borne pathogen that infects between 50 and 100 million people a year.

14 Jan 2021

Antibody recognition of linear SARS-CoV-2 epitopes preserved in mutated B.1.1.7 strain

In a recent medRxiv research paper, the US scientists examined the effects of non-synonymous mutations in the circulating B.1.1.7 strain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on linear antibody epitope signal for viral spike glycoprotein and nucleoprotein – and demonstrated that mutations should not result in immune evasion.

11 Jan 2021

South Korean city shows SARS-CoV-2 clade shift from V to GH over time

A new paper from South Korea describes the evolving SARS-CoV-2 genome in a single city, that of Gwangju, in the southwestern region of this country.

21 Dec 2020

Remdesivir inhibits SARS-CoV-2 replication by preventing RdRp-mediated RNA translocation

A new study describes the in vitro mechanism by which remdesivir kinetically inhibits the replication of the virus that causes COVID-19, SARS-CoV-2.

18 Dec 2020

Structural Protein News and Research

A modified protein mediates development of lung fibrosis after cadmium/carbon black exposure

SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment, study finds

Proteomics shows SARS-CoV-2 NSP7 and NSP8 forms stable dimeric unit

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

Study provides different characteristics of COVID-19

COVID-19 may alter host proteins to cause autoimmunity

GSK-3 inhibitors show promise in treating coronavirus infections

L452R mutation potentially favors adaptive evolution of SARS-CoV-2

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

Viral protein delivery system could facilitate COVID-19 research

Researchers explain SARS-CoV-2's replication-transcription complex

SARS-CoV-2 nucleoprotein increases infectivity of spike-based pseudoviruses

New SARS-CoV-2 variant found in newborn child with seizures in the United States

SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients

E484K mutation is potentially associated with SARS-CoV-2 adaptive fitness

Codon frequency optimization shows SARS-CoV-2 antiviral potential

Researchers discover antibody that blocks the spread of dengue virus

Antibody recognition of linear SARS-CoV-2 epitopes preserved in mutated B.1.1.7 strain

South Korean city shows SARS-CoV-2 clade shift from V to GH over time

Remdesivir inhibits SARS-CoV-2 replication by preventing RdRp-mediated RNA translocation

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News