Cell Biology

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Researchers investigate the feasibility of modifying cholera toxin for targeted delivery to specific organelles

Proteins usually undergo modifications during or after their synthesis in the endoplasmic reticulum (ER) and Golgi apparatus network inside eukaryotic cells.

25 Jul 2022

Lymphatic capillaries act as a signaling hub to control intestinal stem cell activity

To act as a robust barrier against pathogens while also absorbing needed nutrients, the lining of the intestines must regenerate on a daily basis to remain equal to the task.

22 Jul 2022

Study opens up new possible treatment methods for patients with urinary tract infections

Patients who have indwelling urinary catheters often suffer from urinary tract infections, which can be difficult to treat.

22 Jul 2022

Study may help overcome some obstacles to the development of nanoparticle-based drugs

Using nanoparticles to deliver cancer drugs offers a way to hit tumors with large doses of drugs while avoiding the harmful side effects that often come with chemotherapy.

21 Jul 2022

Cancer cells produce small amount of collagen that impacts tumor microbiome and immunity

Cancer cells produce small amounts of their own form of collagen, creating a unique extracellular matrix that affects the tumor microbiome and protects against immune responses, according to a new study by researchers at The University of Texas MD Anderson Cancer Center.

21 Jul 2022

Novel blood test offers unprecedented insight into a patient's cancer make-up

Researchers at the Vancouver Prostate Centre have developed a new blood test that provides unprecedented insight into a patient's cancer make-up, potentially allowing doctors to better select treatment options that will improve patient outcomes.

20 Jul 2022

Study finds white adipose tissue to be the most vulnerable organ to obesity-related metabolic changes

When the body is subjected to a high-calorie diet, the physiological response is not homogeneous and some organs or tissues are more sensitive to metabolic stress.

20 Jul 2022

Scientists find new evidence against using BET inhibitors to treat COVID-19

A while ago, some researchers had suggested that blocking a set of proteins, known as bromodomain and extraterminal (BET) proteins, might be a way to fight COVID-19.

20 Jul 2022

Non-coding 'junk' DNA could potentially contribute to the development of cancer

Scientists have found that non-coding 'junk' DNA, far from being harmless and inert, could potentially contribute to the development of cancer.

19 Jul 2022

Scientists show how lymphatics are associated with microglia and brain development in zebrafish

During the embryonic stage of brain development, some neurons and synapses form properly and connect, but others don't, causing some parts and pieces to be discarded.

19 Jul 2022

Discovery about how a certain protein is activated in tumor cells could lead to better treatments

Better treatments for some of cancer's deadliest forms could be closer due to a University of California, Irvine-led discovery about how a certain protein is activated in tumor cells.

19 Jul 2022

First-of-its-kind roadmap reveals how stem cells become sensory interneurons

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind roadmap detailing how stem cells become sensory interneurons - the cells that enable sensations like touch, pain and itch.

19 Jul 2022

Researchers use high-speed atomic force microscopy to explore the binding mechanism of cadherins

Cell, tissue, and organ structure is maintained by cell-cell adhesion molecules that connect opposing cells. Cadherins are a class of essential cell-cell adhesion molecules for tissue formation and integrity, and defects in cadherin function cause various diseases (e.g., cancer invasion).

19 Jul 2022

Rice researchers use deactivated Cas9 proteins to synthetically trigger the transcription of genes

Rice University researchers have demonstrated that CRISPR-Cas9, increasingly famous as a gene-editing tool, can be employed in powerful additional ways in human cells.

18 Jul 2022

Research describes one of the ways the SARS-CoV-2 virus recruits cells to replicate

An article published in the journal Frontiers in Cellular and Infection Microbiology reports a study by researchers at the State University of Campinas (UNICAMP) and the University of São Paulo (USP) in Brazil showing how a human protein interacts with a SARS-CoV-2 protein, and describing one of the ways the virus that causes COVID-19 recruits cells to replicate.

18 Jul 2022

Wistar scientists reveal a novel ADAR1-SIRT1-p16INK4a axis in regulating cellular senescence

Aging and age-related disorders pose a complex challenge to the biomedical research community. To better understand how senescence is regulated is of high significance to promote healthy aging and treat age-associated disorders.

18 Jul 2022

Study offers new insights into brain metastases in patients with melanoma

Brain metastasis is one of the most common causes of cancer-related deaths and occurs very frequently in patients with advanced melanoma.

18 Jul 2022

Unique tool helps to study how the mechanical forces behind protein folding affect cancer spread

Talin is a protein that controls cellular attachment and movement, but its malfunctioning also allows cancer cells to spread. DCL1 is a tumor-suppressing protein. But scientists don't fully understand how either protein works – or what happens when they don't work the way they should.

15 Jul 2022

Newly characterized stem cell self-renewal factor enables continuous sperm production

Unlike women, who are born with all the eggs they'll ever have, men can continue to produce sperm throughout their adult lives. To do so, they require a constant renewal of spermatogonial stem cells, which give rise to sperm.

15 Jul 2022

Biochemist finds new way to protect healthy leukocytes during chemotherapy

A biochemist from RUDN and IBMC has found a way to protect healthy leukocytes during leukemia chemotherapy. Small nitrogen-containing polyamine molecules give the necessary protection.

14 Jul 2022

Cell Biology

Researchers investigate the feasibility of modifying cholera toxin for targeted delivery to specific organelles

Lymphatic capillaries act as a signaling hub to control intestinal stem cell activity

Study opens up new possible treatment methods for patients with urinary tract infections

Study may help overcome some obstacles to the development of nanoparticle-based drugs

Cancer cells produce small amount of collagen that impacts tumor microbiome and immunity

Novel blood test offers unprecedented insight into a patient's cancer make-up

Study finds white adipose tissue to be the most vulnerable organ to obesity-related metabolic changes

Scientists find new evidence against using BET inhibitors to treat COVID-19

Non-coding 'junk' DNA could potentially contribute to the development of cancer

Scientists show how lymphatics are associated with microglia and brain development in zebrafish

Discovery about how a certain protein is activated in tumor cells could lead to better treatments

First-of-its-kind roadmap reveals how stem cells become sensory interneurons

Researchers use high-speed atomic force microscopy to explore the binding mechanism of cadherins

Rice researchers use deactivated Cas9 proteins to synthetically trigger the transcription of genes

Research describes one of the ways the SARS-CoV-2 virus recruits cells to replicate

Wistar scientists reveal a novel ADAR1-SIRT1-p16INK4a axis in regulating cellular senescence

Study offers new insights into brain metastases in patients with melanoma

Unique tool helps to study how the mechanical forces behind protein folding affect cancer spread

Newly characterized stem cell self-renewal factor enables continuous sperm production

Biochemist finds new way to protect healthy leukocytes during chemotherapy

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