Cell Biology

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Neuroscientists reveal precise connections between retinal nerve cells and the midbrain structure

For the first time, neuroscientists from Charité – Universitätsmedizin Berlin and the Max Planck Institute for Biological Intelligence (currently in the process of being established) have revealed the precise connections between sensory neurons inside the retina and the superior colliculus, a structure in the midbrain.

12 Sep 2022

Morning-loaded and evening-loaded diets produce similar weight loss, with no energy metabolism differences

There's the old saying in dieting that one must "breakfast like a king, lunch like a prince, and dine like a pauper," based on the belief that consuming the bulk of daily calories in the morning optimizes weight loss by burning calories more efficiently and quickly.

12 Sep 2022

Label-free trace detection of bio-molecules by LI-SERS method

A new publication from Opto-Electronic Advances; DOI 10.29026/oea.2022.210121 discusses label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip.

9 Sep 2022

Duke researchers identify chlamydia’s stealthy cloaking device

Chlamydia, the leading cause of sexually transmitted bacterial infections, evades detection and elimination inside human cells by use of a cloaking device. But Duke University researchers have grasped the hem of that invisibility cloak and now hope they can pull it apart.

9 Sep 2022

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food".

9 Sep 2022

Using Q-bodies for imaging intracellular proteins in live cells

Recent advances in imaging technology have made it possible to visualize intracellular dynamics, which offers a better understanding of several key biological principles for accelerating therapeutic development.

9 Sep 2022

Study helps understand how dietary therapies work for epilepsy

Calorie restriction has long been associated with reduced seizures in epilepsy. New research from Boston Children's Hospital helps explain how fasting affects neurons in the brain and could lead the way to new approaches that would avoid the need for fasting or restrictive diets. The findings were published August 30 in the journal Cell Reports.

9 Sep 2022

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Researchers from Dresden uncover a greater neuron production in the frontal lobe during brain development in modern humans than Neandertals, due to the change of a single amino acid in the protein TKTL1.

9 Sep 2022

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020.

9 Sep 2022

Scientists observe how SARS-CoV-2 protein dismantles critical immunity pathway

Over the past two years, scientists have studied the SARS-CoV-2 virus in great detail, laying the foundation for developing COVID-19 vaccines and antiviral treatments.

9 Sep 2022

Intelligent fluorescent microscope for imaging biological events in detail

Imagine you're a PhD student with a fluorescent microscope and a sample of live bacteria. What's the best way use these resources to obtain detailed observations of bacterial division from the sample?

9 Sep 2022

A single genomic change may have given modern humans an advantage over Neanderthals

A single amino acid change in the transketolase-like 1 (TKTL1) protein may have given modern humans an advantage over more ancient contemporaries like Neanderthals by enabling increased neocortical neurogenesis, researchers report.

9 Sep 2022

Stem cell-derived liver cell model could be a valuable tool for future studies on Ebola virus

Ebola virus causes serious infections in humans and in fatal cases, damage and dysfunction of the liver is often present, suggesting that the liver plays a decisive role in disease outcome.

8 Sep 2022

Researchers harness stem cells to study how Ebola virus infects and damages the liver

The Ebola virus was first identified in 1976 near the Ebola River in the Democratic Republic of the Congo. Since then, there have been periodic outbreaks of Ebola Virus Disease (EVD), mostly in Africa, resulting in 13,700 deaths worldwide.

8 Sep 2022

Pitt researchers describe a pathway by which cells repair damaged lysosomes

Today in Nature, University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash.

8 Sep 2022

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

The axolotl Ambystoma mexicanum is a popular pet due to its unique and cute appearance. Unlike other salamanders undergoing metamorphosis, axolotls (pronounced ACK-suh-LAH-tuhl) never outgrow their larval, juvenile stage, a phenomenon called neoteny.

6 Sep 2022

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Researchers from Children's Hospital of Philadelphia used advanced three-dimensional mapping techniques at a microscopic level to identify a multitude of genetic variants and corresponding target gene pairings in the pancreas that are implicated in type 2 diabetes.

6 Sep 2022

Discovery of bacteria-killing toxin could pave the way for new generation of antibiotics

Researchers at McMaster University have discovered a previously unknown bacteria-killing toxin that could pave the way for a new generation of antibiotics.

6 Sep 2022

Somatostatin neurons' properties are specialized in different subregions of the cortex, finds study

The brain's cerebral cortex is made up of distinct regions involved in myriad processes, from sensory perception to cognitive functions like memory, attention, and decision-making. University of Pittsburgh neuroscience researchers have found that the properties of one neuron subtype - somatostatin neurons - are specialized in different subregions of the cortex.

6 Sep 2022

Lactate may have a previously unrecognized role in fighting cancer

A new study by UT Southwestern's Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer.

6 Sep 2022

Cell Biology

Neuroscientists reveal precise connections between retinal nerve cells and the midbrain structure

Morning-loaded and evening-loaded diets produce similar weight loss, with no energy metabolism differences

Label-free trace detection of bio-molecules by LI-SERS method

Duke researchers identify chlamydia’s stealthy cloaking device

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Using Q-bodies for imaging intracellular proteins in live cells

Study helps understand how dietary therapies work for epilepsy

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

Scientists observe how SARS-CoV-2 protein dismantles critical immunity pathway

Intelligent fluorescent microscope for imaging biological events in detail

A single genomic change may have given modern humans an advantage over Neanderthals

Stem cell-derived liver cell model could be a valuable tool for future studies on Ebola virus

Researchers harness stem cells to study how Ebola virus infects and damages the liver

Pitt researchers describe a pathway by which cells repair damaged lysosomes

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Discovery of bacteria-killing toxin could pave the way for new generation of antibiotics

Somatostatin neurons' properties are specialized in different subregions of the cortex, finds study

Lactate may have a previously unrecognized role in fighting cancer

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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