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Maraviroc drug safe, well-tolerated when taken as PrEP to prevent HIV infection

Maraviroc, an oral drug used to treat HIV infection, is safe and well-tolerated when taken daily as pre-exposure prophylaxis (PrEP) to prevent HIV infection by HIV-uninfected men who have sex with men (MSM) at increased risk for acquiring HIV.

25 Feb 2016

Zika outbreak highlights need for developing and evaluating new vaccines for pregnant women

The recent outbreak of Zika virus disease and its link to fetal development highlights the need for pregnant women and those of reproductive age to be a priority group for developing and evaluating new vaccines and vaccine guidelines for Zika and other emerging infectious diseases, say the authors of a new Viewpoint article in JAMA.

25 Feb 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

Two investigational Ebola vaccines well-tolerated in Phase 2 clinical trial

Two investigational vaccines designed to protect against Ebola virus disease were well-tolerated and induced an immune response among 1,000 vaccinated participants in the Phase 2 randomized, placebo-controlled clinical trial called PREVAIL I.

25 Feb 2016

Stop TB Partnership's new initiative to increase access to two new life-saving TB medicines

The Stop TB Partnership's Global Drug Facility (GDF) will announce a new initiative to increase access to bedaquiline and delamanid - the two new life-saving medicines recently approved for the treatment of multi-drug resistant tuberculosis (TB). The GDF will share how it is expanding existing and developing new public-private partnerships to expedite and maximize access to these two critical medicines.

25 Feb 2016

Research: Impaired immune response significantly involved in rare autoimmune diseases

In the context of the multicentre EU project "INTRICATE" under the management of Renate Kain of the Clinical Institute for Pathology of MedUni Vienna, the effects of infections on the generation of rare autoimmune diseases such as granulomatous polyangiitis (GPA), a systemic disease of the vascular system, are examined.

25 Feb 2016

Tackling Zika virus: Challenges ahead

Health officials, drug companies, governments and the public are scrambling to understand and combat the Zika virus. The virus was first identified almost 70 years ago, but little is known about it. And now, officials suspect it could be related to a rise in microcephaly cases in affected countries.

25 Feb 2016

Okayama University e-Bulletin highlights role of designer DNA-binding proteins to fight viral infections in agriculture, medicine

This issue includes a feature on designer DNA-binding proteins to combat viral infections in agriculture and medicine; news items include updates of official opening of the Okayama University Silicon Valley Office at Fremont (CA), and international collaboration work with Xiamen University; research highlights on immunizing plants; identification of gene Vrn-D4 for enabling wheat to adapt to areas with warm winters; importance of introgression on intra-specific genetic differentiation and adaptive divergence; an interesting twist on supercooled liquid water; and manufacturing denim in Okayama.

25 Feb 2016

Ebola survivors and close contacts have high burden of illness

Preliminary findings from PREVAIL III, a study of Ebola virus disease (EVD) survivors being conducted in Liberia, indicate that both Ebola survivors and their close contacts have a high burden of illness. However, the prevalence of eye, musculoskeletal, and neurological complications was greater among the individuals who survived EVD.

25 Feb 2016

Sangamo presents immunological data from SB-728-T HIV clinical study at CROI 2016

Sangamo BioSciences, Inc., the leader in therapeutic genome editing, announced the presentation of immunological data from the Company's clinical trials of SB-728-T, a ZFP Therapeutic designed to provide functional control of HIV.

25 Feb 2016

Study: Most Ebola survivors experience brain symptoms more than six months after initial infection

Most of the 82 Ebola survivors in a new study from the world's largest Ebola outbreak had brain symptoms more than six months after the initial infection. The preliminary results will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.

25 Feb 2016

Study highlights presence of antibiotic stewardship practices in most VA-affiliated facilities

New research highlights the robust presence of antibiotic stewardship practices in most Veterans Administration-affiliated facilities, manifested in both formal and informal policies. The study was published online today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.

24 Feb 2016

Researchers discover new JE virus transmission route

Japanese Encephalitis (JE) virus causes serious inflammation of the brain in people and fertility problems in pigs. Mosquitoes were previously the only known transmission route. However, the virus can also be spread from pig to pig by direct contact, and this could enable it to circulate in pigs during the mosquito-free winter season.

24 Feb 2016

New research shows copper can destroy MRSA in touch contamination

New research from the University of Southampton shows that copper can destroy MRSA spread by touching and fingertip contamination of surfaces.

24 Feb 2016

UEA research paves way for new wave of drugs to kill superbugs

Scientists at the University of East Anglia are getting closer to solving the problem of antibiotic resistance.

24 Feb 2016

Single dose of zoledronic acid can inhibit bone loss in HIV-infected patients

A single dose of the drug zoledronic acid was found to inhibit the bone loss that is common in HIV-infected patients and that is increased during the first two years of treatment with antiretroviral therapy (ART).

24 Feb 2016

New definitions and clinical criteria for sepsis, septic shock

Clifford S. Deutschman, MS, MD, vice chair of research in the Department of Pediatrics at Cohen Children's Medical Center and an investigator at The Feinstein Institute for Medical Research , presented new definitions and clinical criteria for sepsis and septic shock at the Society of Critical Care Medicine's 45th Critical Care Congress in Orlando, FL.

24 Feb 2016

Influenza virus can able to circumvent the body's immune system

Influenza is able to mask itself, so that the virus is not initially detected by our immune system. This is the result of new research from Aarhus University. The researchers behind the study hope that the discovery can be used to develop better treatment against influenza and chronic inflammation conditions such as rheumatoid arthritis.

24 Feb 2016

ViiV Healthcare presents positive results from LATTE-2 study at CROI

ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Pfizer Inc. and Shionogi Limited as shareholders, today presented positive results from the LATTE-2 study at the Conference on Retroviruses and Opportunistic Infections (CROI) in Boston. Headline results were announced in November 2015.

24 Feb 2016

First patient dosed in Novan's Phase 3 program to evaluate efficacy of SB204 Gel in treatment of acne

Novan, Inc. today announced that the first patient has been dosed in its Phase 3 program to evaluate the efficacy and safety of its topical nitric oxide product candidate SB204 Gel in the treatment of acne vulgaris ("acne"). The Company is running two identically designed Phase 3 pivotal trials in parallel and expects to report top-line results in the first half of 2017.

23 Feb 2016

Disease/Infection News

Maraviroc drug safe, well-tolerated when taken as PrEP to prevent HIV infection

Zika outbreak highlights need for developing and evaluating new vaccines for pregnant women

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Two investigational Ebola vaccines well-tolerated in Phase 2 clinical trial

Stop TB Partnership's new initiative to increase access to two new life-saving TB medicines

Research: Impaired immune response significantly involved in rare autoimmune diseases

Tackling Zika virus: Challenges ahead

Okayama University e-Bulletin highlights role of designer DNA-binding proteins to fight viral infections in agriculture, medicine

Ebola survivors and close contacts have high burden of illness

Sangamo presents immunological data from SB-728-T HIV clinical study at CROI 2016

Study: Most Ebola survivors experience brain symptoms more than six months after initial infection

Study highlights presence of antibiotic stewardship practices in most VA-affiliated facilities

Researchers discover new JE virus transmission route

New research shows copper can destroy MRSA in touch contamination

UEA research paves way for new wave of drugs to kill superbugs

Single dose of zoledronic acid can inhibit bone loss in HIV-infected patients

New definitions and clinical criteria for sepsis, septic shock

Influenza virus can able to circumvent the body's immune system

ViiV Healthcare presents positive results from LATTE-2 study at CROI

First patient dosed in Novan's Phase 3 program to evaluate efficacy of SB204 Gel in treatment of acne

The Proteoform Puzzle: Unlocking the Next Frontier

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

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