Disease/Infection News

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Chronic suppurative lung disease: an interview with Dr Robyn Marsh

Chronic suppurative lung disease, or CSLD, is used to describe a range of lung diseases characterised by a chronic wet cough and progressive lung damage. We are interested in the non-cystic fibrosis forms of the disease with a focus on bronchiectasis – the severe form of CSLD.

26 Nov 2012

Max Planck scientists identify unknown proteins of the herpesvirus

The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system, the scientists of the Max Planck Institute of Biochemistry in Martinsried near Munich and their collaboration partners at the University of California in San Francisco have shown that the genome of this virus contains much more information than previously assumed.

26 Nov 2012

Avermectin family of drugs shows promise against TB

A well-established family of drugs used to treat parasitic diseases is showing surprising potential as a therapy for tuberculosis (TB), according to new research from University of British Columbia microbiologists.

26 Nov 2012

mRNA vaccines offer protection against influenza A virus infections in various animal models

CureVac GmbH, a clinical stage biopharmaceutical company developing a new class of therapies and vaccines based on mRNA, and the German Federal Research Institute for Animal Health, Friedrich-Loeffler-Institute (FLI), Germany, today announced that mRNA vaccines (RNActive) based on the company's RNA technology platform have the potential to provide effective protection against infectious diseases.

26 Nov 2012

Lymphopenia driven diseases and the orphan drug industry: an interview with Damian Marron, CEO of Cytheris

Lymphopenia is when you lack the T cells of your immune system. T cells are very important for controlling infection. Probably the most known cause of lymphopenia is HIV.

23 Nov 2012

Research reveals surprisingly complex protein-coding capacity of human cytomegalovirus

New findings reveal the surprisingly complex protein-coding capacity of the human cytomegalovirus, or HCMV, and provide the first steps toward understanding how the virus manipulates human cells during infection. The genome of the HCMV was first sequenced over 20 years ago, but researchers have now investigated the proteome-the complete set of expressed proteins-of this common pathogen as well.

23 Nov 2012

Major advance in understanding how flu viruses replicate within infected cells

Scientists at The Scripps Research Institute (TSRI) have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to "see" one of influenza's essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus's vulnerabilities that are sure to be of interest to drug developers.

23 Nov 2012

People worried about catching infections in public transport during flu season

As flu season gets underway, public transport such as buses, trains and subway trains head the list of places where people worry about catching viruses and infections, according to new research by Microban.

23 Nov 2012

Behavioural support programme to make TB patients quit smoking receives BUPA Foundation prize

The BUPA Foundation has awarded a high commendation prize for research led by the University of York into effective ways of helping tuberculosis patients in Pakistan to give up smoking.

23 Nov 2012

Online flu survey launched in the UK

Does “man flu” exist? How effective is the flu vaccine? And do pets keep you healthy? These are just some of the questions scientists from the London School of Hygiene & Tropical Medicine want to explore as they launch a nationwide flu survey.

22 Nov 2012

Single dose of Medicago's vaccine could offer cross-protection against flu

Researchers recently found that a single dose of a vaccine being developed by Medicago, Inc., a publicly traded biopharmaceutical company, could protect against not only the avian influenza (H5N1) strain it was designed for, but also another H5N1 strain and a strain of a different flu subtype, called H2N2.

22 Nov 2012

DiscoGnosis project aims to develop rapid malaria test

An estimated 500 million people become infected with malaria each year. The disease is often lethal - particularly in tropical developing countries with insufficient health care services. The infected suffer from a high fever. As this is also the case with other germs, however, it is important to conduct a rapid and precise analysis to determine the cause of the disease for a successful therapy.

22 Nov 2012

Microbiologists discover how the spread of antibiotic resistance works in pneumococcus

Antibiotic resistance results from bacteria's uncanny ability to morph and adapt, outwitting pharmaceuticals that are supposed to kill them. But exactly how the bacteria acquire and spread that resistance inside individuals carrying them is not well-established for most bacterial organisms.

22 Nov 2012

AMFm should continue, improvements should be explored

The "grand experiment" of the Affordable Medicines Facility-malaria (AMFm) -- a pilot program that aims to get artemisinin-based combination therapies (ACTs) into rural areas of several African nations -- "seems likely to end, its successes underrated and potential improvements not yet explored," a Nature editorial says.

22 Nov 2012

Meningitis outbreak could prompt call for executive jail time

A tough prosecutor and high public scrutiny could mean jail time for executives of the New England Compounding Center -- the pharmacy at the center of the deadly meningitis outbreak. In the meantime, the pharmacy's lawyers counter that the executives had no direct hand in the illnesses.

22 Nov 2012

UNAIDS report indicates end to AIDS possible but challenges remain

UNAIDS' World AIDS Day report: Results, released on Tuesday, said the goal of eventually ending the global AIDS epidemic "is more than merely visionary" and "is entirely feasible," primarily because of "historic success" in scaling up HIV programs and improving access to antiretroviral drugs to treat and prevent HIV, Reuters reports.

22 Nov 2012

Nobel laureate Aung San Suu Kyi accepts role as UNAIDS ambassador

"Nobel peace prize winner Aung San Suu Kyi has accepted a new role with UNAIDS to advance efforts to eliminate stigma and discrimination against those affected by the epidemic," the U.N. News Centre reports.

22 Nov 2012

AVAC, amfAR release first progress report on Action Agenda to End AIDS

AVAC and amfAR, the Foundation for AIDS Research, on Tuesday released the first in a series of quarterly reports following up on the release of the Action Agenda to End AIDS, which was launched in July at the XIX International AIDS Conference (AIDS 2012), according to a joint press release.

22 Nov 2012

Incoming Global Fund head Mark Dybul says organization has 'strong forward trajectory'

The Global Fund to Fight AIDS, Tuberculosis and Malaria Board recently made several decisions that will affect the future of the organization, including appointing former U.S. Global AIDS Coordinator Ambassador Mark Dybul as executive director and adopting a new funding model, Nature reports in an article examining the history and future of the Fund.

22 Nov 2012

Dropping of cold chain requirement for meningitis vaccine will improve access, IRIN reports

IRIN examines how the WHO's recent declaration that the MenAfriVac meningitis A vaccine can be transported or stored for up to four days without refrigeration will affect immunization campaigns in Africa's meningitis belt, which runs from Senegal to Ethiopia.

22 Nov 2012