Disease/Infection News

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Alios BioPharma, Vertex initiate ALS-2200 and ALS-2158 clinical study in HCV

Vertex Pharmaceuticals Incorporated and Alios BioPharma, Inc. today announced the initiation of two clinical studies for the nucleotide analogues ALS-2200 and ALS-2158, which are inhibitors of the hepatitis C NS5B polymerase.

12 Dec 2011

New guidelines for managing latent tuberculosis from CDC

The U.S. Centers for Disease Control and Prevention (CDC) has released new guidelines on treating so-called “latent” tuberculosis (TB) infection in the United States. They suggest the course of the therapy from about 9 months could be shortened to 3 months.

11 Dec 2011

Progress in AIDS fight in peril as governments renege on funding pledges

In this Toronto Star opinion piece, Richard Elliott, executive director of the Canadian HIV/AIDS Legal Network, and Nicci Stein, executive director of the Interagency Coalition on AIDS and Development, discuss how progress made in the fight against HIV/AIDS over the last 30 years "is in peril, due to governments reneging on repeated promises to fund the fight against the pandemic."

9 Dec 2011

MCC invests $122M in Lesotho health system to address key challenges, including HIV, TB

"The Millennium Challenge Corporation (MCC), through its partnership with the Millennium Challenge Account-Lesotho, is helping Lesotho address key challenges in its health sector through a $122 million investment in health infrastructure and health systems," IIP Digital reports.

9 Dec 2011

Report says African mothers confused over infant-feeding options to prevent HIV transmission

Some women in African nations are "dangerously confused about the best nutritional path to protect their children from contracting [HIV]," a new report, based on research by community health workers from Cameroon, Cote d'Ivoire, Ethiopia, and Nigeria, shows, PlusNews reports.

9 Dec 2011

Science examines HIV prevention trials, challenges to implementing new strategies

Science examines recent successes in clinical trials in the HIV prevention field, limitations to mathematical models resulting from these trials, and funding issues facing campaigns to ramp up HIV prevention interventions.

9 Dec 2011

Global Fund official delivers speech at ICASA closing plenary session

The 16th International Conference on AIDS and Sexually Transmitted Infections in Africa (ICASA) ended on Thursday in Addis Ababa, Ethiopia, where "the final plenary session ... left the audience with a notion of hope and urgency that despite the Global Fund's cancellation of Round 11 disbursements, the organization will continue to campaign, raise funds and place pressure on governments in both the donor and recipient arenas," an ICASA news article reports (12/8).

9 Dec 2011

New pediatric formula for Chagas disease treatment developed in Brazil

"A new pediatric formulation developed in Brazil holds out hope for a cure for over 90 percent of newborn babies infected with Chagas disease, a parasitic infection endemic in 21 Latin American countries, where it kills more people every year than malaria," Inter Press Service reports.

9 Dec 2011

Examining visceral leishmaniasis/HIV co-infection in East Africa

In this post in the Global Network for Neglected Tropical Diseases' (NTDs) "End the Neglect" blog, Julien Potet, NTD policy adviser at Medecins Sans Frontieres' Campaign for Access to Essential Medicines, examines the treatment of visceral leishmaniasis among people living with HIV in East Africa.

9 Dec 2011

Addressing gender-based violence through PEPFAR programs

Daniela Ligiero of the State Department, Sasha Mital of the CDC, and Diana Prieto of USAID, who are co-chairs of the PEPFAR Gender Technical Working Group, write about the "intersection between gender-based violence (GBV) and its impact on HIV risk and access to HIV prevention and treatment for most-at-risk populations (MARPs)" in this post on the State Department's "DipNote" blog.

9 Dec 2011

Shorter, effective treatment for latent TB infection

Research, led by Timothy Sterling, M.D., professor of Medicine at Vanderbilt University Medical Center, has led to an important change in CDC recommendations in the regimen for prevention of the centuries-old scourge, tuberculosis (TB).

9 Dec 2011

Prevention practices for catheter-associated urinary tract infections lacking in most hospitals

Hospitals are working harder than ever to prevent hospital-acquired infections, but a nationwide survey shows few are aggressively combating the most common one - catheter-associated urinary tract infections.

9 Dec 2011

New international consortium aims to prepare researchers for next pandemic

"A group of health organizations [on Wednesday] launched a new international consortium to better prepare the clinical research community to respond to the next pandemic or other emerging health threat," CIDRAP News reports (Schnirring, 12/7).

9 Dec 2011

'Disinfectants' may reduce risk of E. coli outbreaks

Some E. coli bacteria are harmless and some are dangerous from the outset. Then some become dangerous when they are subjected to viral infection. Researchers are working to find tools that will reduce the risk of this happening.

9 Dec 2011

New methods speed up process of identifying harmful E. coli bacteria

New methods speed up the process of identifying the subgroup of E. coli bacteria responsible for an outbreak of illness. Swift identification may spare lives.

9 Dec 2011

Experimental sublingual vaccine shows promise against influenza infection

Scientists from the International Vaccine Institute (IVI) have discovered that an antigen common to most influenza viruses, and commonly referred to as matrix protein 2 (M2), when administered under the tongue could protect mice against experimental infection caused by various influenza viruses, including the highly pathogenic avian H5 virus and the pandemic H1 ("swine flu") virus.

9 Dec 2011

Paper calls for strong steps to control global crisis of antibiotic-resistant infections

Shahriar Mobashery, a University of Notre Dame researcher, is one of the coauthors of a new paper by a group of the world's leading scientists in academia and industry that calls for strong steps to be taken to control the global crisis of antibiotic resistance in bacteria. The group issued a priority list of steps that need to be taken on a global scale to resolve the crisis.

9 Dec 2011

CSIS publishes reports on immunization and global health

The Center for Strategic & International Studies on Wednesday released two reports on immunizations and global health. "The Future of Global Immunization: Will the Promise Be Fulfilled?," by Stephen Cochi of the CDC, "outlines 10 important issues facing the global vaccine and immunization agenda."

9 Dec 2011

Goal of AIDS-free generation achievable through 'AIDS transition'

In this Foreign Affairs opinion piece, Mead Over, a senior fellow at the Center for Global Development, says the goal of an "AIDS-free generation" is attainable, "[b]ut not if treatment continues to take precedence over prevention."

9 Dec 2011

Enrollment complete in Boehringer Ingelheim's BI 201335 Phase III trial for HCV

Boehringer Ingelheim today announced that the final patient has been randomised to treatment in the large-scale Phase III clinical trial programme for BI 201335, its investigational, oral protease inhibitor for the treatment of chronic hepatitis C virus.

9 Dec 2011