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Sanofi-aventis commences teriflunomide Phase III study in RMS patients treated with interferon beta

Sanofi-aventis announced today the initiation of a multinational Phase III study evaluating the efficacy and safety of two doses of once daily teriflunomide (7mg or 14mg) versus placebo in patients with relapsing multiple sclerosis (RMS) treated with interferon beta (IFN beta).

26 Oct 2010

Panel examines global food security ahead of LA Francophonie summit; Global Fund, UNAIDS call for greater cooperation among French-speaking countries

World Trade Organization Director-General Pascal Lamy highlighted concerns about the global food situation on Friday during a roundtable discussion on the sidelines of the International Organisation of La Francophonie summit, Agence France-Presse reports.

26 Oct 2010

Cholera epidemic in Haiti persists despite slow down in fatalities

"A multinational medical response has slowed deaths in a Haitian cholera epidemic that has killed more than 250 people so far, but the outbreak is likely to widen, a senior U.N. official said on Sunday," Reuters reports. The U.N., Haitian government and aid partners "have launched a major effort to try to contain the epidemic" of more than 3,000 cases in the country so far (Delva, 10/25). The New York Times reports that the death rate, according to the Haitian government, has "declined - from 10.6 percent of known cases three days earlier to 8.2 percent now."

26 Oct 2010

Salk discovers potential new target for MS

Scientists are closer to solving one of the many mysteries of multiple sclerosis and other demyelinating diseases, thanks to a recent study conducted at the Salk Institute for Biological Studies. The research revealed a previously unknown connection between two ion channels, which, when misaligned, can cause the many bizarre symptoms that characterize the condition.

26 Oct 2010

SNP array's snapshot of Anopheles gambiae genome can help eliminate malaria

The development and first use of a high-density SNP array for the malaria vector mosquito have established 400,000 genetic markers capable of revealing new insights into how the insect adapts to outsmart insecticides and other preventive measures, according to findings published in the current edition of the journal Science.

26 Oct 2010

Study reveals two enzymes help immune cells deploy pathogen-killing traps

A new study reveals that two enzymes help immune cells deploy pathogen-killing traps by unraveling and using the chromatin (DNA and its associated proteins) contained in the cells' nuclei to form defensive webs. The study appears online on October 25 in The Journal of Cell Biology.

26 Oct 2010

Pathogenic listeria tricks intestinal cells to cause sickness

Pathogenic listeria tricks intestinal cells into helping it pass through those cells to make people ill, and, if that doesn't work, the bacteria simply goes around the cells, according to a Purdue University study.

26 Oct 2010

LigoCyte presents Phase I/II study results of NoV vaccine for gastroenteritis at IDSA Meeting

LigoCyte Pharmaceuticals, Inc., a private, clinical-stage biopharmaceuticals company developing innovative vaccine products, today announced positive results from a Phase I/II challenge study of its norovirus virus-like particle (VLP) vaccine candidate.

26 Oct 2010

Sanofi Pasteur presents Fluzone quadrivalent Phase II trial data for influenza at IDSA Annual Meeting

Sanofi Pasteur, the vaccines division of the sanofi-aventis Group announced today the results of a clinical trial of its investigational Fluzone Quadrivalent (Influenza Virus Vaccine) compared to the currently licensed Fluzone (Influenza Virus Vaccine). Data from the Phase II trial assessing the immunogenicity and safety of the investigational quadrivalent vaccine were presented at the 48th Annual Meeting of the Infectious Diseases Society of America in Vancouver, British Columbia.

26 Oct 2010

Dietary intake of PUFAs associated with decreased prevalence of periodontitis

Periodontitis, a common inflammatory disease in which gum tissue separates from teeth, leads to accumulation of bacteria and potential bone and tooth loss. Although traditional treatments concentrate on the bacterial infection, more recent strategies target the inflammatory response.

26 Oct 2010

Researchers investigate impact of fungal toxin on birth defects

A Creighton University School of Medicine researcher has been awarded a $2.7 million grant by the National Institutes of Health (NIH) to investigate a possible link between the ingestion of tortillas and corn-based food products contaminated with a fungal toxin and increased risk for birth defects.

26 Oct 2010

Vertex initiates OPTIMIZE Phase 3b study in patients infected with genotype 1 HCV

Vertex Pharmaceuticals Incorporated today announced the initiation of a Phase 3b study called OPTIMIZE that will evaluate twice-daily (BID) dosing of a telaprevir-based combination regimen in people chronically infected with genotype 1 hepatitis C virus (HCV) who have not been treated previously. This is the first Phase 3 study to evaluate twice-daily dosing of a protease inhibitor for the treatment of hepatitis C. OPTIMIZE will not include a control arm of pegylated-interferon and ribavirin alone.

26 Oct 2010

Northern Territory reports worst mosquito plague ever

Authorities in Australia’s Northern Territory report the worst mosquito plague since records began in 1979. An organization helping homeless people in Darwin is distributing insect repellent and coils to combat the mosquito onslaught.

25 Oct 2010

Haiti cholera epidemic abates

The rate of deaths in Haiti's cholera epidemic slowed on Monday. This followed a multinational medical operation scale up to limit the spread of an outbreak that has killed 259 people in the earthquake-hit country. However Haitian and international health authorities are still bracing for more cases before the epidemic is finally controlled. So far, the epidemic has mostly impacted two rural central Haitian provinces, Artibonite and Center, along with the few isolated cases in the capital Port-au-Prince. Suspected cases have also been reported in the Nord and Sud provinces.

25 Oct 2010

Inviragen commences Phase 1 clinical trial of DENVax dengue vaccine in Colombia

Inviragen, a company developing vaccines to protect against infectious diseases worldwide, and the Program for the Study and Control of Tropical Diseases (PECET), jointly announced the initiation of a Phase 1 clinical trial of DENVax™ in Colombia. DENVax is an investigational vaccine designed to provide protection against all four dengue virus serotypes. The trial will measure the safety of DENVax as well as the immune responses induced by the vaccine in healthy adults in Rionegro, Colombia.

25 Oct 2010

FDA approves Roche's real-time PCR COBAS TaqMan HCV Test, v2.0

Roche announced today that the U.S. Food & Drug Administration (FDA) has approved the real-time PCR COBAS® TaqMan® HCV Test, v2.0. Clinical research organizations have depended on COBAS® TaqMan® technology to support hepatitis C pharmaceutical trials and development.

25 Oct 2010

World Vision increases response in cholera affected Haiti

As the cholera outbreak continues to spread in the Artibonite region of Haiti, World Vision is increasing its response in affected areas, pre-positioning much-needed health supplies and preparing residents in its displacement camps in Port-au-Prince with critical, life-saving health and hygiene messages.

25 Oct 2010

Immune Network enters letter of intent to acquire Immunitor oral vaccine technology

Immune Network Ltd. advises that a clinical trial of V5 Immunitor oral vaccine was published earlier this month demonstrating an unexpected powerful effect against tuberculosis, including multi-drug-resistant tuberculosis (MDR-TB) and tuberculosis that is complicated by co-infection with HIV and hepatitis C (HCV).

25 Oct 2010

Non communicable diseases will cost India USD237 billion during 2006-15

Health experts participating at a roundtable organised by India Health Progress(IHP) on economic and social impact of non-communicable diseases in India are of the opinion that a concerted effort is required to address the growing burden.

25 Oct 2010

Popular Mechanics recognizes three NSF-funded projects with innovation Breakthrough Awards

Popular Mechanics has recognized three NSF-funded projects with innovation Breakthrough Awards: an artificial retina returning sight to those who have lost it; a system that uses "controlled rocking" and energy-dissipating fuses to help buildings withstand earthquakes; and an inexpensive medical microscope built for cell-phones that allows doctors in rural villages to identify malaria-infected blood cells.

25 Oct 2010

Disease/Infection News

Sanofi-aventis commences teriflunomide Phase III study in RMS patients treated with interferon beta

Panel examines global food security ahead of LA Francophonie summit; Global Fund, UNAIDS call for greater cooperation among French-speaking countries

Cholera epidemic in Haiti persists despite slow down in fatalities

Salk discovers potential new target for MS

SNP array's snapshot of Anopheles gambiae genome can help eliminate malaria

Study reveals two enzymes help immune cells deploy pathogen-killing traps

Pathogenic listeria tricks intestinal cells to cause sickness

LigoCyte presents Phase I/II study results of NoV vaccine for gastroenteritis at IDSA Meeting

Sanofi Pasteur presents Fluzone quadrivalent Phase II trial data for influenza at IDSA Annual Meeting

Dietary intake of PUFAs associated with decreased prevalence of periodontitis

Researchers investigate impact of fungal toxin on birth defects

Vertex initiates OPTIMIZE Phase 3b study in patients infected with genotype 1 HCV

Northern Territory reports worst mosquito plague ever

Haiti cholera epidemic abates

Inviragen commences Phase 1 clinical trial of DENVax dengue vaccine in Colombia

FDA approves Roche's real-time PCR COBAS TaqMan HCV Test, v2.0

World Vision increases response in cholera affected Haiti

Immune Network enters letter of intent to acquire Immunitor oral vaccine technology

Non communicable diseases will cost India USD237 billion during 2006-15

Popular Mechanics recognizes three NSF-funded projects with innovation Breakthrough Awards

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