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Researchers to wind down HIV prevention trial in women after interim results find drug not offering protection from HIV

Researchers on Monday announced they were calling off a trial to test whether taking an oral HIV drug reduces the risk of HIV infection in women after interim analysis of the study showed women taking the medication were no less likely to become infected with HIV than those who were not taking the medicine, the Associated Press reports.

20 Apr 2011

IBD patients at greater risk of death if infected with Clostridium difficile

Patients admitted to hospital with inflammatory bowel disease (IBD) face a sixfold greater risk of death if they become infected with Clostridium difficile, a new study has found. The researchers say IBD patients should be screened on admission to protect them from serious illness.

20 Apr 2011

Diagnostic test Xpert MTB/RIF proven fast and effective in low-resource settings

The Lancet published a significant development for TB diagnostics yesterday with concrete and encouraging study outcomes on the effectiveness of the new Xpert MTB/RIF test for TB and rifampicin resistance in realistic health care field conditions. One of the authors, Prof. Mark Nicol of the University of Cape Town (South Africa) who contributed to this study, is an EDCTP Senior Fellow. The article demonstrates that the test can effectively be used in low-resource settings to simplify early and accurate diagnosis of patients. The potential impact is a reduction in the morbidity associated with diagnostic delay, dropout and mistreatment. The article has appeared online on 19 April 2011 and will be published in volume 377 on 30 April 2011.

20 Apr 2011

SERI selects AB SCIEX TripleTOF 5600 system to test chronic eye inflammations

AB SCIEX, a global leader in life science analytical technologies, today announced that the Singapore Eye Research Institute, an internationally known eye research center, will advance biomarker candidates it identified for chronic inflammatory eye conditions into large-scale clinical trials for validation with the AB SCIEX TripleTOF™ 5600 System.

20 Apr 2011

Acorda receives patent for AMPYRA tablets to improve walking in MS patients

Acorda Therapeutics, Inc. today announced that the United States Patent and Trademark Office has allowed U.S. Patent Application No. 11/010,828 entitled "Sustained Release Aminopyridine Composition."

20 Apr 2011

MSF calls on African governments, WHO to switch to newer, more expensive treatment for severe malaria

Nearly 200,000 deaths from severe malaria could be averted if African governments replaced the low-cost antimalarial quinine with the more expensive but more effective drug artesunate, according to a report (.pdf) released Tuesday by Medicins Sans Frontieres (MSF), Reuters reports (Kelland, 4/19).

20 Apr 2011

FHI to stop FEM-PrEP study of HIV prevention among heterosexual women

On the heels of Centers for Disease Control announcement earlier today that an ongoing study of the use of Gilead's top selling AIDS treatment, Truvada, as a possible form of pre-exposure prophylaxis for HIV prevention in women is being abruptly halted because the, "…trial could not demonstrate efficacy," the AIDS Healthcare Foundation renewed its call on Gilead Sciences to slow its fast track pursuit of its application for FDA approval of use of its AIDS drug as a possible form of HIV prevention.

20 Apr 2011

U.N. General Assembly passes resolution urging renewed efforts to fight malaria

Ahead of World Malaria Day on April 25, the U.N. General Assembly on Monday adopted a resolution urging governments, U.N. agencies, nongovernmental organizations (NGOs), and private foundations to accelerate their efforts and build upon established successes in the fight against the disease, particularly in Africa, Deutsche Presse-Agentur/M&C reports.

20 Apr 2011

Researchers find relation between strain of tuberculosis and Canadian fur trade

Researchers have found that a strain of tuberculosis responsible for devastating some isolated Aboriginal populations in Canada was first introduced to these communities by French Canadian fur traders between 1710 and 1870.

20 Apr 2011

African AIDS drug trial stopped prematurely

One of the studies in three African countries where women were given an AIDS drug to prevent HIV infection is being stopped because the project is not working, researchers said Monday. These women on the trial were taking a daily dose of the drug Truvada or a look-alike placebo pill and had an equal chance of becoming infected. The ones taking Truvada were expected to have had a much lower infection rate.

19 Apr 2011

Chembio initiates FDA Modular PMA process for DPP HIV 1/2 Screening Assay

Chembio Diagnostics, Inc., which develops, manufactures, markets and licenses point-of-care diagnostic tests, reported it recently filed the first module of its Pre-Marketing Approval (PMA) application to the United States Food & Drug Administration for its DPP® HIV 1/2 Screening Assay.

19 Apr 2011

Commonly used strategy has no effect in reducing MRSA, VRE in hospital ICUs

A new research study of the effect of a commonly used strategy to reduce the spread of antibiotic-resistant bacteria in hospital intensive care units shows that the strategy had no significant effect. That's the surprising finding of a multisite study led by Mayo Clinic investigators.

19 Apr 2011

Vancouver's supervised injection site reduces overdose mortality rates to 35%

Illicit drug overdose deaths in Vancouver's Downtown Eastside dropped by 35 per cent after the establishment of Insite, North America's first supervised injection facility, according a new study by researchers at the University of British Columbia and the British Columbia Centre for Excellence in HIV/AIDS.

19 Apr 2011

Countries agree to draft framework on virus sharing, WHO says

After almost four years of negotiations, the WHO on Saturday announced it had reached an agreement on sharing flu virus samples, Agence-France Presse reports.

19 Apr 2011

People with infectious mononucleosis, low UVB exposure may face high risk of MS

New research suggests that people who are exposed to low levels of sunlight coupled with a history of having a common virus known as mononucleosis may be at greater odds of developing multiple sclerosis than those without the virus.

19 Apr 2011

NIH awards U of M's scientist with $10 million grant for HIV research

Reuben Harris, professor in the University of Minnesota's College of Biological Sciences, has been awarded a five-year, $10 million grant from the National Institutes of Health to direct a large-scale research effort to study a human antiviral protein with potential for treating HIV and other viral diseases.

19 Apr 2011

Also in global health news: U.N., Libyan government reach deal over aid; USAID monitoring HIV/AIDS in Philippines; WFP warns of Afghanistan food shortages; U.N. appeals for more aid in Cote d'Ivoire, Namibia

U.N. Secretary-General Ban Ki-moon on Monday at a press conference in Hungary announced that the organization had reached an agreement with the Libyan government to provide humanitarian aid in the country's capital city of Tripoli, the Associated Press reports.

19 Apr 2011

Groundbreaking news on Dengue

Daily temperature fluctuations, not just high temperatures, play a significant role in the transmission of dengue, a deadly mosquito-borne disease that strikes millions of people in tropical and subtropical countries, according to ground-breaking research led by French, Thailand and U.S. scientists and conceived by medical entomologist Thomas Scott of the University of California, Davis.

18 Apr 2011

Quest Diagnostics launches AccuType IL28B test for HCV

Quest Diagnostics Incorporated, the world's leading provider of diagnostic testing, information and services, today announced the availability of its AccuType® IL28B test for aiding in the prediction of patient response to peginterferon alpha-based therapy for hepatitis C virus (HCV) infection.

From Quest Diagnostics 18 Apr 2011

iOWH's semisynthetic ART enters production, distribution phase to combat malaria

The Institute for OneWorld Health, a non-profit drug development organization, announced today that its development of an alternative source of artemisinin using pioneering synthetic biology technology has successfully entered the production and distribution phase.

18 Apr 2011