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Neurodegenerative disease-causing infectious protein can erupt from healthy brain tissue: Study

In a startling new study that involved research on both sides of the Atlantic, scientists from The Scripps Research Institute in Florida and the University College London Institute of Neurology in England have shown for the first time that abnormal prions, bits of infectious protein devoid of DNA or RNA that can cause fatal neurodegenerative disease, can suddenly erupt from healthy brain tissue.

27 Jul 2010

EFINTD awards 850,000 Euros for medical research on neglected tropical diseases in Africa

More than one billion people all over the world suffer from tropical diseases which are mostly unknown to the wider public and have also been neglected economically. In a joint effort with four other European foundations, the Volkswagen Foundation has opened a second round of funding for African scientists conducting research on these neglected diseases.

27 Jul 2010

Female sexual dysfunction can affect quality of life: Research

Almost two-thirds of females attending a general urology practice reported that they suffered from sexual dysfunction, according to a paper in the August issue of BJUI. Dysfunction rose with age in all categories except orgasm, with more than half of women aged from 18 to 30 reporting orgasm problems, significantly higher than women aged 31 to 54.

27 Jul 2010

Advanced Life Sciences enters agreement with UBC to develop antimicrobial peptides

Advanced Life Sciences Holdings, Inc., a biopharmaceutical company engaged in the discovery, development and commercialization of novel drugs in the therapeutic areas of infection, oncology and respiratory diseases, today announced that the Company has entered into a sponsored research and option agreement with The University of British Columbia (UBC) to develop several antimicrobial peptides.

27 Jul 2010

Global Fund director calls on emerging countries to invest more in programs to reduce HIV/AIDS, TB and malaria at AIDS 2010

On the final day of the International AIDS Conference-AIDS 2010 Friday, Michel Kazatchkine, executive director of the Global Fund to Fight AIDS, Tuberculosis and Malaria called upon "China, India and other fast-growing economies" to chip in to help close the funding gap in efforts to battle HIV/AIDS, Agence France-Presse reports. "Until now, these countries have been recipients of AIDS funds, not donors," the news service writes.

27 Jul 2010

Albert Einstein College of Medicine receives research grant to help people with MDR-TB

For the third time in four months, the National Institute of Allergy and Infectious Diseases of the National Institutes of Health has awarded Albert Einstein College of Medicine of Yeshiva University a research grant aimed at helping people infected with multidrug-resistant tuberculosis. Taken together, all three NIH grants total $8.57 million.

27 Jul 2010

Study on interactions between new antitubercular drug candidates SQ109 and TMC207

Sequella, Inc., a clinical-stage biopharmaceutical company developing drugs for treatment of life-threatening infectious diseases, announced today the publication of studies in the scientific journal Antimicrobial Agents and Chemotherapy on synergy between SQ109, its lead drug candidate for the treatment of TB, and TMC207, Tibotec lead TB drug candidate:

27 Jul 2010

AHF denies BMS sales reprepresentatives access to healthcare centers

Today AIDS Healthcare Foundation (AHF) announced that it has banned pharmaceutical sales representatives from Bristol-Myers Squibb (BMS) from calling on AHF's medical providers and staff in its sixteen U.S. healthcare centers. The decision is based on BMS' refusal to lower the price of its key AIDS drug Reyataz for cash-strapped AIDS Drug Assistance Programs.

27 Jul 2010

Quidel recommences shipments of QuickVue+ lateral flow diagnostic test for infectious mononucleosis

Quidel Corporation, a leading provider of rapid diagnostic testing solutions, announced today that it has begun taking orders for its QuickVue®+ lateral flow diagnostic test for infectious mononucleosis. Due to strong customer demand, the Company has restarted manufacturing its previous mononucleosis product with shipments to customers expected during the first week of August.

27 Jul 2010

Scientists discover mechanism of herpes virus cell entry machinery

The mechanism by which a herpes virus invades cells has remained a mystery to scientists, but now research from Tufts University and the University of Pennsylvania reveals the unusual structure of a key member of the protein complex that allows a herpes virus to invade cells.The new map details an essential piece of the herpes virus "cell-entry machinery," providing scientists with a new target for antiviral drugs.

27 Jul 2010

Study analyses anesthetic effects on surgical site infections

A study appearing in the August 2010 issue of Anesthesiology found that patients receiving a total hip or knee replacement in Taiwan had a higher incidence of surgical site infections (SSIs) when general anesthesia was administered for the operation than when the same procedures were performed under epidural/spinal (regional) anesthesia.

27 Jul 2010

AIDS 2010 opinions: U.S. funding for global HIV/AIDS programs; Empowering women, girls in fight against HIV/AIDS

The first letter, Ambassador Eric Goosby, U.S. Global AIDS Coordinator, addresses an opinion piece by Desmond Tutu, archbishop emeritus of Cape Town and honorary chairman of the Global AIDS Alliance. Goosby writes, "The United States has been and continues to be the global leader on HIV/AIDS. The best metric of our success is lives saved." Goosby cites an increased number of people on antiretrovirals financed by the United States and a commitment to treat 4 million more as part of the Global Health Initiative.

27 Jul 2010

Can-Fite's CF102 decreases HCV viral load in liver cancer patients

Can-Fite BioPharma Ltd, a biotechnology company traded on the Tel Aviv Stock Exchange reported today that a significant decrease in HCV viral load was detected in 3 patients with liver cancer who are treated daily orally with CF102. The company is studying CF102 as a treatment for liver cancer (hepatocellular carcinoma, or HCC). The results announced today relate to data which came out of a Phase 1/2 clinical trial of CF102 in the treatment of patients with advanced HCC.

26 Jul 2010

Tibotec submits NDA for TMC278 anti-HIV compound to FDA

Tibotec Pharmaceuticals today announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for TMC278 (rilpivirine), an investigational non-nucleoside reverse transcriptase inhibitor (NNRTI), being studied for once-daily use with other antiretroviral agents in treatment-naive HIV-1-infected adults. If approved, TMC278 will be the third anti-HIV compound to be introduced by Tibotec Pharmaceuticals.

26 Jul 2010

Vical's prophylactic Vaxfectin-formulated pDNA vaccine effective against HSV-2 in animal model

Vical Incorporated today announced that its prophylactic Vaxfectin®-formulated plasmid DNA (pDNA) vaccine against herpes simplex virus type 2 (HSV-2) protected mice against lethal challenge, provided sterilizing immunity and inhibited viral counts at both the primary and latent infection sites. The Vaxfectin® adjuvant substantially improved vaccine effectiveness. A related vaccine significantly reduced the recurrence of HSV-2 lesions in a therapeutic model using guinea pigs with latent infection.

26 Jul 2010

Sec. of State Clinton signs 5-year AIDS control partnership agreement with Vietnam

During her trip to Vietnam, Secretary of State Hillary Rodham Clinton "engaged in health diplomacy by visiting the Ngoc Lam Pagoda orphanage for AIDS-affected children," Foreign Policy's blog "Madam Secretary" reports.

26 Jul 2010

Toolkits to facilitate implementation of new WHO guidelines for reducing HIV infections issued

At the XVIII International AIDS Conference, the Elizabeth Glaser Pediatric AIDS Foundation has issued the first of a series of three linked toolkits to facilitate the adaptation and implementation of the revised World Health Organization recommendations for four technical areas: antiretroviral drugs for treating pregnant women and preventing HIV infection in infants, infant feeding in the context of HIV, and antiretroviral treatment for children, adolescents, and adults.

26 Jul 2010

AU Summit panel focuses on water, sanitation to meet MDG targets in Africa

African countries should focus on preventing diarrhea - the biggest killer of children in Africa - in order to achieve Millennium Development Goal targets, Yunia Musaazi, WaterAid's East Africa policy advisor, told delegates at the 15th African Union Summit, PANA/Afrique en ligne reports.

26 Jul 2010

Scientists study Legionella's reprogramming on cells for survival, propagation

When it infects the lungs, the Legionnaire's bacterium Legionella pneumophila causes acute pneumonia. The pathogen's modus operandi is particularly ingenious: it infiltrates deliberately into cells of the human immune system and injects a host of proteins which then interfere in the normal cellular processes. Scientists from the Max Planck Institute of Molecular Physiology in Dortmund have now discovered how Legionella reprogrammes the cells to ensure its own survival and to propagate. They examined a protein used by the pathogen to divert the material transport within the cells for its own purposes.

26 Jul 2010

AIDS 2010: Obama, Clinton vow U.S. support to global fight against HIV/AIDS

During the closing ceremonies of the International AIDS Conference-AIDS 2010, President Barack Obama "on Friday pledged to redouble efforts to fight HIV and AIDS through his Global Health Initiative, despite dealing with economic hard times in the wake of a global recession," Reuters reports. According to the news service, "Obama and his Secretary of State Hillary Clinton said their focus was on a broad, sustainable and effective approach to the global epidemic" (Kelland, 7/23).

26 Jul 2010

Disease/Infection News

Neurodegenerative disease-causing infectious protein can erupt from healthy brain tissue: Study

EFINTD awards 850,000 Euros for medical research on neglected tropical diseases in Africa

Female sexual dysfunction can affect quality of life: Research

Advanced Life Sciences enters agreement with UBC to develop antimicrobial peptides

Global Fund director calls on emerging countries to invest more in programs to reduce HIV/AIDS, TB and malaria at AIDS 2010

Albert Einstein College of Medicine receives research grant to help people with MDR-TB

Study on interactions between new antitubercular drug candidates SQ109 and TMC207

AHF denies BMS sales reprepresentatives access to healthcare centers

Quidel recommences shipments of QuickVue+ lateral flow diagnostic test for infectious mononucleosis

Scientists discover mechanism of herpes virus cell entry machinery

Study analyses anesthetic effects on surgical site infections

AIDS 2010 opinions: U.S. funding for global HIV/AIDS programs; Empowering women, girls in fight against HIV/AIDS

Can-Fite's CF102 decreases HCV viral load in liver cancer patients

Tibotec submits NDA for TMC278 anti-HIV compound to FDA

Vical's prophylactic Vaxfectin-formulated pDNA vaccine effective against HSV-2 in animal model

Sec. of State Clinton signs 5-year AIDS control partnership agreement with Vietnam

Toolkits to facilitate implementation of new WHO guidelines for reducing HIV infections issued

AU Summit panel focuses on water, sanitation to meet MDG targets in Africa

Scientists study Legionella's reprogramming on cells for survival, propagation

AIDS 2010: Obama, Clinton vow U.S. support to global fight against HIV/AIDS

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