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Two repurposed drugs and a blue dye show potential as SARS-CoV-2 entry inhibitors

A new multidisciplinary study from Australia, published in the open-access journal mBio, shows that three compounds used to treat cystic fibrosis, dry eye, and a specific medical dye may lead to future strategies for the treatment of coronavirus disease (COVID-19).

25 Apr 2021

Single dose of Pfizer-BioNTech COVID-19 vaccine induces immunity in CML patients

Researchers in the UK have shown that a single dose of the Pfizer-BioNTech vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced antibody and cellular responses in patients with chronic myeloid leukemia (CML) who were taking tyrosine kinase inhibitors.

25 Apr 2021

Pfizer-BioNTech COVID-19 vaccine shows real-world efficacy, despite the circulation of B.1.1.7 variant

Researchers in the UK have conducted a study showing the real-world effectiveness of Pfizer-BioNTech’s vaccine at protecting against symptomatic coronavirus disease 2019 (COVID-19) when it is administered in line with the original dosing schedule.

25 Apr 2021

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Can a high dose of vitamin D administered on admission to hospital improve the condition of patients with moderate or severe COVID-19? The answer is no, according to a Brazilian study published in the Journal of the American Medical Association.

23 Apr 2021

Studies provide insights on youth-focused messaging to promote COVID-19 mitigation behaviors

Now that teens and young adults across the country account for an increasing share of COVID-19 cases, and many have become eligible for vaccination, several recently published studies based on polls of this age group provide insights into the kinds of messaging that might work best for both preventing transmission and vaccine uptake.

23 Apr 2021

FDA, CDC lift recommended pause on the use of Janssen COVID-19 vaccine in the U.S.

Following a thorough safety review, including two meetings of the CDC's Advisory Committee on Immunization Practices, the U.S. Food and Drug Administration and the U.S. Centers for Disease Control and Prevention have determined that the recommended pause regarding the use of the Johnson & Johnson (Janssen) COVID-19 Vaccine in the U.S. should be lifted and use of the vaccine should resume.

23 Apr 2021

Disruptions to essential health services due to COVID-19 pandemic persist in 90% of countries

The second round of a World Health Organization "pulse survey" reveals that over one year into the COVID-19 pandemic, substantial disruptions persist, with about 90% of countries still reporting one or more disruptions to essential health services, marking no substantial global change since the first survey conducted in the summer of 2020.

23 Apr 2021

Study reports on safety of COVID-19 mRNA vaccines in pregnancy

Researchers used different surveillance systems in the United States to track adverse outcomes after coronavirus disease 2019 (COVID-19) vaccination in pregnant people and found no major safety flags.

23 Apr 2021

NIH to conduct large trial for COVID-19 polyclonal antibody therapies

The National Institutes of Health (NIH) in the USA are to conduct a large-scale clinical trial to evaluate a new fully-human polyclonal antibody therapy targeted at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19).

23 Apr 2021

World Malaria Day 2021: An interview with Sir Brian Greenwood

News-Medical interviews Sir Brian Greenwood about raising awareness for malaria during the COVID-19 pandemic and achieving elimination of the disease.

23 Apr 2021

New study demonstrates the effectiveness of COVID-19 vaccine in specific sub-populations

Several weeks following the publication of the large real-world Covid-19 vaccine effectiveness study by the Clalit Research Institute in Collaboration with Harvard University in the New England Journal of Medicine (NEJM), additional results focusing on vaccine effectiveness in specific sub-populations have now been published.

23 Apr 2021

Ongoing testing of immunized individuals will be key to mitigate future COVID-19 outbreaks

In rare cases, people who have been fully vaccinated against COVID and are immune to the virus can nevertheless develop the disease.

23 Apr 2021

Researchers identify natural molecule that blocks the binding of human antibodies to SARS-CoV-2

Researchers have found that a natural molecule can effectively block the binding of a subset of human antibodies to SARS-CoV-2. The discovery may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.

23 Apr 2021

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunization regimen.

23 Apr 2021

Individuals with lower income or greater Republican orientation were associated with reduced social distancing

Using nearly a year of anonymous geolocation data from 15-17 million cell phone users in 3,037 United States counties, investigators have found that individuals with lower income per capita or greater Republican orientation were associated with significantly reduced social distancing throughout the study period from March 2020 through January 2021.

23 Apr 2021

COVID-19 survivors have increased risk of death for at least six months

As the COVID-19 pandemic has progressed, it has become clear that many survivors - even those who had mild cases - continue to manage a variety of health problems long after the initial infection should have resolved.

23 Apr 2021

Celastrol shows potential anti-SARS-CoV-2 activity

A new study published on the bioRxiv* preprint server focuses on the in-silico predictions to repurpose existing drug compounds, that may have the ability to reverse the SARS-CoV-2 gene expression induced in host cells.

23 Apr 2021

Artificial intelligence helps identify new key-lock pairs against coronavirus

The human immune defense is based on the ability of white blood cells to accurately identify disease-causing pathogens and to initiate a defense reaction against them.

23 Apr 2021

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

A team of scientists from the United States has recently compared the immune response elicited by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Their findings reveal that, unlike vaccination, natural SARS-CoV-2 infection is associated with a robust interferon response together with an induction of cytotoxic gene expression in peripheral blood lymphocytes. The study is currently available on the medRxiv* preprint server.

22 Apr 2021

Preclinical study from NIH/Moderna: Correlates of SARS-CoV-2 immunity in non-human primates

Researchers in the United States have shown that the antibody response induced by the Moderna mRNA-1273 vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a correlate of immune protection against coronavirus disease 2019 (COVID-19) in non-human primates.

22 Apr 2021

Disease/Infection News

Two repurposed drugs and a blue dye show potential as SARS-CoV-2 entry inhibitors

Single dose of Pfizer-BioNTech COVID-19 vaccine induces immunity in CML patients

Pfizer-BioNTech COVID-19 vaccine shows real-world efficacy, despite the circulation of B.1.1.7 variant

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Studies provide insights on youth-focused messaging to promote COVID-19 mitigation behaviors

FDA, CDC lift recommended pause on the use of Janssen COVID-19 vaccine in the U.S.

Disruptions to essential health services due to COVID-19 pandemic persist in 90% of countries

Study reports on safety of COVID-19 mRNA vaccines in pregnancy

NIH to conduct large trial for COVID-19 polyclonal antibody therapies

World Malaria Day 2021: An interview with Sir Brian Greenwood

New study demonstrates the effectiveness of COVID-19 vaccine in specific sub-populations

Ongoing testing of immunized individuals will be key to mitigate future COVID-19 outbreaks

Researchers identify natural molecule that blocks the binding of human antibodies to SARS-CoV-2

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

Individuals with lower income or greater Republican orientation were associated with reduced social distancing

COVID-19 survivors have increased risk of death for at least six months

Celastrol shows potential anti-SARS-CoV-2 activity

Artificial intelligence helps identify new key-lock pairs against coronavirus

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

Preclinical study from NIH/Moderna: Correlates of SARS-CoV-2 immunity in non-human primates

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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