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Gene variant that increases colon cancer risk

A paper published in this week's Journal of Clinical Oncology says Transforming Growth Factor Beta Receptor 1*6A (TGFBR1*6A) - a mutated gene present in nearly one in eight people and the most commonly inherited cancer susceptibility gene identified so far - might be responsible for a significant proportion of familial colorectal cancers.

2 May 2005

E. coli poses significant public health threat to seniors in the U.S.

A new study finds that E. coli bacteremia - a potentially life-threatening bloodstream infection caused by a common bacteria also associated with less dangerous urinary tract infections - poses a significant public health threat in the United States, especially among seniors.

2 May 2005

Specific genes play key role in the of regulation of human-blood stem cells

This work is the first to validate gene expression analysis in human stem cells with functional experiments. The findings also suggest that changes in the expression of genes associated with universal cell signaling pathways can have a substantial impact on human stem cell behavior.

2 May 2005

Small number of genes can predict response to chronic hepatitis C therapy

For the first time, physicians at University Health Network and University of Toronto have identified a small subset of genes that can predict whether a patient with chronic Hepatitis C will be able to respond to current treatments.

2 May 2005

Antidepressant medication or psychotherapy may be effective in treating chronically depressed patients when the other is not

Switching from an antidepressant medication to psychotherapy or vice versa may improve symptoms in chronically depressed patients who prove unresponsive to their initial treatment, according to an article in the May issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

2 May 2005

Exercise training in ordinary people affects the activity of 500 genes

A new study from Karolinska Institutet in Stockholm shows that hundreds of genes in the thigh muscle are activated in regular cycle training. The study also reveals that great differences in training response may be due to the ability in some people to activate their genes much more forcefully. The study is published May 2 in FASEB Journal.

2 May 2005

Loneliness and social network appear to make independent contributions to immunity

A new study at Carnegie Mellon University in Pittsburgh confirms how college challenges both mind and body, by demonstrating that lonely first-year students mounted a weaker immune response to the flu shot than did other students. The study appears in the May issue of Health Psychology, which is published by the American Psychological Association (APA).

2 May 2005

Movie ratings fail to distinguish violent content

What do the family film "The Jungle Book" and the action thriller "True Lies" have in common? Both contain similar amounts of violence despite respective PG and R ratings.

2 May 2005

Vitamins E and C confirmed safe at high doses

Fourteen leading safety and antioxidant experts reviewed the available scientific literature on vitamins E and C and concluded vitamin E is safe for the general population at intakes up to 1600 IU daily and vitamin C is safe at up to 2000 mg daily, according to a new article published in the April issue of the American Journal of Clinical Nutrition (AJCN).

2 May 2005

Being a party animal is good for you!

Scientists in the US say that being the life and soul of the party apart from being great fun could be good for the heart.

1 May 2005

HRT now linked to cancer of the womb

A new study of more than 700,000 women has found, say the researchers, that Hormone replacement therapy (HRT) can increase the risk of cancer of the womb, depending on the form of HRT used.

1 May 2005

Community efforts can reduce alcohol fatalities

Communities can decrease alcohol-related fatal crashes by providing better access to substance abuse treatment while reducing the availability of alcohol in the community, according to a new study supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). A report of the study appears in the April, 2005 issue of the journal Injury Prevention.

1 May 2005

New prognostic markers help identify risk of relapse

A recently completed clinical study has found new prognostic markers that may help clinicians identify those children with leukaemia who are at high risk of relapse and are most in need of intensified treatment to improve their chance of survival.

1 May 2005

Traffic pollution may increase risk of breast cancer

Exposure to carcinogens in traffic emissions at particular lifetime points may increase the risk of developing breast cancer in women who are lifetime nonsmokers, a study by epidemiologists and geographers at the University at Buffalo has found.

1 May 2005

Tumors of the pituitary gland are more common than thought

A recent study found that tumors of the pituitary gland are more common than many health care professionals realize, with national prevalence rates averaging 16.7 percent. To neurosurgeon Dr. Gail Rosseau, this isn't surprising.

1 May 2005

War veterans are more likely to be heavy drinkers, heavy smokers and obese

Men who fought in World War II, the Korean War, and the Vietnam War are more likely to be heavy drinkers, heavy smokers and obese than men who are non-combat veterans or non-veterans, according to a study presented at the American Heart Association's 45th annual Conference of Cardiovascular Disease, Epidemiology and Prevention.

1 May 2005

Discrimination leads to coronary artery calcification in African-American women

The more discrimination African-American women report, the more likely they are to have coronary artery calcification, a buildup of calcium in the vessels that is associated with atherosclerosis, according to a study presented at the American Heart Association's 45th Annual Conference on Cardiovascular Disease Epidemiology and Prevention.

1 May 2005

Severely obese children have lipoprotein profiles that signal early risk of cardiovascular disease and the metabolic syndrome

"The message is urgent about the importance of prevention of cardiovascular disease in childhood. Lifestyle modification with appropriate diet and exercise can reduce cardiovascular risk in children," said lead author Daniel L. Preud'Homme, M.D., associate professor of medicine at the Wright State University School of Medicine and director of the lipid clinic at The Children's Medical Center, both in Dayton, Ohio.

1 May 2005

Fiber supplements may lower cardiovascular risk in type 2 diabetics

Fiber supplements lower "bad" low-density lipoprotein (LDL) cholesterol and increase "good" high-density lipoprotein (HDL) cholesterol in people with type 2 diabetes, according to a study presented at the American Heart Association's Sixth Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology.

1 May 2005

Japanese women have lower recurrence of breast cancer

Early-stage breast cancer patients of Japanese descent that are treated with a lumpectomy and radiation therapy are more likely to be cured of their cancer than women of other ancestries, according to a new study published in the May 2005 issue of the International Journal of Radiation Oncology-Biology-Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology.

1 May 2005