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Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

In this groundbreaking study, researchers developed a mucosal adenoviral-vector vaccine, ChAd-SARS-CoV-2-S, which demonstrated sustained and robust immunity against a challenging Omicron variant in nonhuman primates, indicating a promising direction for durable COVID-19 protection strategies. Unlike traditional intramuscular vaccines, this mucosal vaccine elicited a comprehensive immune response, potentially paving the way for more effective and long-lasting COVID-19 vaccines.

9 Nov 2023

FORTE accrues first 1000 participants for highly anticipated colorectal cancer prevention trial

FORTE (NRG-CC005) is a highly anticipated colorectal cancer prevention trial led by NRG Oncology examining surveillance colonoscopy intervals in participants who have non-advanced polyps.

9 Nov 2023

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Patients with HER2-positive breast cancer that has started to spread to other parts of the body survive for longer if they are treated with a new drug called pyrotinib, according to results from the longest follow-up of the PHOEBE randomized clinical trial in China.

8 Nov 2023

Study compares the immunogenicity and safety of two SARS-CoV-2 vaccines

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019. Since then, extensive efforts have been made to develop and evaluate vaccines to combat the virus.

8 Nov 2023

UTHSC's drug candidate for advanced prostate cancer goes to first clinical trial

A drug candidate developed by researchers at the University of Tennessee Health Science Center for advanced metastatic castration-resistant prostate cancer is now in its first clinical trial.

6 Nov 2023

Targeted drug may offer a new treatment option for patients with relapsed blood cancer

A new targeted drug, studied by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James), may offer a new treatment option for patients with blood cancers, including chronic lymphocytic leukemia (CLL) and Non-Hodgkin lymphoma (NHL) whose disease has stopped responding to standard treatments.

6 Nov 2023

Sotagliflozin provides kidney and heart benefits in patients with diabetes and chronic kidney disease

Sodium-glucose cotransporter-2 (SGLT2) inhibitors, which are medications that lower blood sugar levels among other effects, provide kidney- and heart-related benefits to patients with and without diabetes.

3 Nov 2023

High-impact clinical trial results to be presented at ASN Kidney Week 2023

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2023 November 1–November 5.

3 Nov 2023

Docetaxel improves survival in men with high-grade prostate cancer and low PSA

Men with high-grade prostate cancer and low prostate-specific antigen (PSA) levels have a poor prognosis.

1 Nov 2023

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

A small clinical trial with a pharmacokinetic sub-study, led by a world-renowned pharmacologist at the University of Houston, has demonstrated the promising effectiveness of the drug Riluzole for improving functionality in people with acute spinal cord injuries (SCI) if the drug is taken within 12 hours post-injury.

1 Nov 2023

The development of a machine-learned scoring function of human preference in the context of early drug discovery campaigns

In a recent study published in Nature Communications, researchers developed a scoring mechanism based on artificial intelligence for early drug discovery campaigns that might be utilized for compound prioritizing, motif rationalization, and biased drug design.

1 Nov 2023

University of Cincinnati to lead NIH StrokeNet for next five years

The University of Cincinnati and UC Health have been renewed as the National Coordinating Center of the National Institutes of Health (NIH) StrokeNet, which is the primary infrastructure for multicenter trials of stroke funded by NIH and the pipeline for new potential treatments for adults and children with stroke and those at risk for stroke.

30 Oct 2023

New treatment combination shows promise for metastatic colorectal cancer patients with rare genetic mutation

An international Phase 3 clinical trial found that metastatic colorectal cancer patients with a rare genetic tumor mutation called KRAS G12C experienced superior progression-free survival rates compared to standard of care when offered a combination treatment of KRAS inhibitor sotorasib and monoclonal antibody panitumumab.

27 Oct 2023

Breast cancer screening trial expands internationally to enhance diversity

A clinical trial led by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) demonstrates how diversity among study participants is vital for reducing outcomes disparities.

27 Oct 2023

New drug candidate found to be highly effective in treating rare sight-threatening eye infection

A drug candidate, based on pioneering UCL and Moorfields Eye Hospital research and currently under development by SIFI S.p.A., has been found to be highly effective in treating a rare sight-threatening eye infection in a new international clinical trial.

26 Oct 2023

Dato-DXd improves progression-free survival in patients with metastatic non-squamous NSCLC

Treatment with datopotamab deruxtecan (Dato-DXd), a novel Trop-2 directed antibody-drug conjugate, was found to significantly improve progression-free survival in patients with metastatic non-small cell lung cancer, an improvement that was primarily driven by patients with non-squamous tumors.

26 Oct 2023

Global clinical trial provides new evidence on simvastatin and vitamin C for COVID-19

The Global Coalition for Adaptive Research (GCAR) in collaboration with the University of Pittsburgh and UPMC, on behalf of the REMAP-CAP Investigator Network, announce clinical trial results examining the use of vitamin C and simvastatin to treat severely ill patients with COVID-19.

25 Oct 2023

New course of treatment with existing drugs for cervical cancer reduces risk of death by 35%

A course of treatment with existing drugs prior to chemoradiation led to a 35% reduction in the risk of death or return of cancer, in trial results presented by researchers from UCL and UCLH.

25 Oct 2023

HIF-2α inhibitor belzutifan significantly reduces progression of clear cell renal cell carcinoma

Belzutifan significantly reduced the risk of progression of clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer, in patients previously treated with immune checkpoint inhibitors and anti-angiogenic therapies compared with everolimus in a phase 3 clinical trial.

24 Oct 2023

Perioperative durvalumab may change standard-of-care for patients with resectable lung cancer

A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial reported by researchers at The University of Texas MD Anderson Cancer Center.

24 Oct 2023

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Drug Trial News

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

FORTE accrues first 1000 participants for highly anticipated colorectal cancer prevention trial

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Study compares the immunogenicity and safety of two SARS-CoV-2 vaccines

UTHSC's drug candidate for advanced prostate cancer goes to first clinical trial

Targeted drug may offer a new treatment option for patients with relapsed blood cancer

Sotagliflozin provides kidney and heart benefits in patients with diabetes and chronic kidney disease

High-impact clinical trial results to be presented at ASN Kidney Week 2023

Docetaxel improves survival in men with high-grade prostate cancer and low PSA

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

The development of a machine-learned scoring function of human preference in the context of early drug discovery campaigns

University of Cincinnati to lead NIH StrokeNet for next five years

New treatment combination shows promise for metastatic colorectal cancer patients with rare genetic mutation

Breast cancer screening trial expands internationally to enhance diversity

New drug candidate found to be highly effective in treating rare sight-threatening eye infection

Dato-DXd improves progression-free survival in patients with metastatic non-squamous NSCLC

Global clinical trial provides new evidence on simvastatin and vitamin C for COVID-19

New course of treatment with existing drugs for cervical cancer reduces risk of death by 35%

HIF-2α inhibitor belzutifan significantly reduces progression of clear cell renal cell carcinoma

Perioperative durvalumab may change standard-of-care for patients with resectable lung cancer

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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