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Sucampo Pharmaceuticals initiates phase 3 trial of Lubiprostone for chronic idiopathic constipation in Japan

Sucampo Pharmaceuticals, Inc. today announced that its subsidiary, Sucampo Pharma, Ltd., has initiated enrollment and completed the randomization of the first patient into the pivotal phase 3 efficacy trial of lubiprostone for chronic idiopathic constipation (CIC) in Japan.

20 May 2009

Sodium channel-blocking agent shows promise as a potential treatment for cystic fibrosis

Cystic fibrosis patients may benefit from a new therapy that increases airway hydration, preventing the buildup of mucous, which is a key factor in the disease, according to researchers at Parion Sciences in Durham, N.C.

17 May 2009

Pirfenidone shows promise for idiopathic pulmonary fibrosis

A large, well-controlled, multi-national clinical trial program has demonstrated the effectiveness and safety of what may become the first FDA-approved medicine for idiopathic pulmonary fibrosis, or IPF.

17 May 2009

Pregabalin shows potential as treatment for hot flashes

A pill used for nerve pain offers women relief from hot flashes, Mayo Clinic researchers report at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO).

17 May 2009

Herpes drug Acyclovir does not reduce risk of HIV transmission, does slow HIV progression, study says

The drug acyclovir, which suppresses herpes simplex virus-2, does not reduce the risk of HIV transmission when taken by HIV-positive people who also have herpes, according to a study conducted by researchers at the University of Washington, United Press International reports.

14 May 2009

Participants in antidepressant drug trials are atypical patients

One reason antidepressant medication treatments do not work as well in real life as they do in clinical studies could be the limited type of study participants selected, researchers at UT Southwestern Medical Center have found.

12 May 2009

Schering-Plough starts patient enrollment in phase 3 trial for Acadesine

Schering-Plough Corporation today announced the start of patient enrollment in RED-CABG, the Phase 3 Trial for acadesine, an investigational, potentially first-in-class adenosine regulating agent (ARA). Acadesine was licensed from PeriCor Therapeutics, Inc., a privately held specialty biopharmaceutical company.

12 May 2009

Merck Serono starts second phase III trial of Safinamide in advanced Parkinson's

Merck Serono announced today the initiation of the SETTLE study. This study will evaluate the efficacy and safety of a dose range of safinamide (50-100 mg once daily) as add-on therapy to a stable dose of levodopa, in mid- to late-stage Parkinson's disease patients with motor fluctuations compared to placebo.

7 May 2009

Amsterdam Molecular Therapeutics commences preregistration trial for Glybera

Amsterdam Molecular Therapeutics announced today the treatment of the first patient in a preregistration clinical trial with Glybera. This gene therapy product targets lipoprotein lipase deficiency (LPLD), a seriously debilitating and potentially lethal disease.

7 May 2009

Metoclopramide versus droperidol for extreme nausea, vomiting during pregnancy

Nausea and vomiting are telltale indicators of pregnancy, affecting more than 80 percent of future mothers. For a few moms-to-be, symptoms can become so severe that hospitalization is required.

6 May 2009

New anticonvulsant compound prevents seizure progression in model of epilepsy

Carnegie Mellon University researchers have identified a new anticonvulsant compound that has the potential to stop the development of epilepsy. The findings are published in the March issue of the journal Epilepsia.

4 May 2009

A negative mGluR5 allosteric modulator shows efficacy in treating acute migraine attacks

When migraine strikes, because of severe pain, often accompanied by nausea and sensitivity to light and sound, sufferers are effectively disabled for up to 72 hours.

30 Apr 2009

Histone deacetylase inhibitors show promise against head and neck cancer

A laboratory study by researchers at Albert Einstein College of Medicine of Yeshiva University suggests that an anti-cancer compound studied for treating blood cancers may also help in treating cancers of the head and neck.

30 Apr 2009

Pregabalin shows potential for restless legs syndrome - improves sleep

A drug widely used to treat seizures and anxiety appears to be an effective treatment for restless legs syndrome (RLS) and helps people with the disorder get a better night's sleep, according to a study that will be presented as part of the Late-breaking Science Program at the American Academy of Neurology's 61st Annual Meeting in Seattle.

29 Apr 2009

Anti-viral drug telaprevir improves response, halves duration of hepatitis C treatment

The addition of the anti-viral drug telaprevir to a standard treatment for hepatitis C can shorten the duration of therapy and increase the number of patients who can be cured of their disease, according to the results of study coordinated by investigators from the Duke Clinical Research Institute (DCRI).

29 Apr 2009

Many Black teens consider themselves victims of racial discrimination

A three-year study of African American youths' perceptions of racial discrimination has found that many Black teens consider themselves victims of racial discrimination, and these perceptions are linked to how they feel about being Black, particularly their views of how the broader society sees African Americans.

29 Apr 2009

Ferring Pharmaceuticals launches new trial of Degarelix for intermittent androgen deprivation therapy

Ferring Pharmaceuticals has announced the launch of a Phase IIIB clinical trial of degarelix for injection, a new injectable gonadotropin-releasing hormone (GnRH) receptor antagonist approved by the U.S. Food and Drug Administration (FDA) for the treatment of hormone sensitive advanced prostate cancer.

27 Apr 2009

Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells

Cancer cells, like bacteria, can develop resistance to drug therapy. In fact, research suggests strongly that multidrug-resistant cancer cells that remain alive after chemotherapy are responsible for the reappearance of tumors and the poor prognosis for patients whose cancer recurs.

27 Apr 2009

Roche and Pharmasset start phase IIb clinical trial of R7128 nucleoside polymerase inhibitor for chronic hepatitis C

Pharmasset, Inc. and Roche have announced that the first patient has been dosed in a Phase IIb study of R7128, the nucleoside polymerase inhibitor most advanced in development for the treatment of chronic hepatitis C (HCV).

26 Apr 2009

New lidocaine-prilocaine spray may treat premature ejaculation

A new topical spray, is a safe and effective treatment for premature ejaculation.

26 Apr 2009

Drug Trial News

Sucampo Pharmaceuticals initiates phase 3 trial of Lubiprostone for chronic idiopathic constipation in Japan

Sodium channel-blocking agent shows promise as a potential treatment for cystic fibrosis

Pirfenidone shows promise for idiopathic pulmonary fibrosis

Pregabalin shows potential as treatment for hot flashes

Herpes drug Acyclovir does not reduce risk of HIV transmission, does slow HIV progression, study says

Participants in antidepressant drug trials are atypical patients

Schering-Plough starts patient enrollment in phase 3 trial for Acadesine

Merck Serono starts second phase III trial of Safinamide in advanced Parkinson's

Amsterdam Molecular Therapeutics commences preregistration trial for Glybera

Metoclopramide versus droperidol for extreme nausea, vomiting during pregnancy

New anticonvulsant compound prevents seizure progression in model of epilepsy

A negative mGluR5 allosteric modulator shows efficacy in treating acute migraine attacks

Histone deacetylase inhibitors show promise against head and neck cancer

Pregabalin shows potential for restless legs syndrome - improves sleep

Anti-viral drug telaprevir improves response, halves duration of hepatitis C treatment

Many Black teens consider themselves victims of racial discrimination

Ferring Pharmaceuticals launches new trial of Degarelix for intermittent androgen deprivation therapy

Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells

Roche and Pharmasset start phase IIb clinical trial of R7128 nucleoside polymerase inhibitor for chronic hepatitis C

New lidocaine-prilocaine spray may treat premature ejaculation

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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