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Enzyme plays key role in cell fate

The road to death or differentiation follows a similar course in embryonic stem cells, said researchers at Baylor College of Medicine in Houston in a report that appears online today in the journal Cell Stem Cell.

5 Jun 2008

Long-term pesticide exposure may increase diabetes risk

Licensed pesticide applicators who used chlorinated pesticides on more than 100 days in their lifetime were at greater risk of diabetes, according to researchers from the National Institutes of Health (NIH). The associations between specific pesticides and incident diabetes ranged from a 20 percent to a 200 percent increase in risk, said the scientists with the NIH's National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI).

4 Jun 2008

The effect of alcohol advertising on young people

The advertising of alcohol, the marketing of alcoholic products, peer pressure and parental influence all play a part in the level of alcohol consumption among young people.

4 Jun 2008

Job stress causing depression in workers in Victoria

A study by researchers at Melbourne University has found that almost one in six cases of depression among workers in Victoria are caused by job stress.

3 Jun 2008

Incidence of melanoma and other malignancies among rheumatoid arthritis patients treated with Methotrexate

A chronic, inflammatory disease of unknown origin, rheumatoid arthritis (RA) affects about 1 percent of adults worldwide. Marked by joint destruction, RA often leads to disability and diminished quality of life. It can also lead to an early death from cancer.

3 Jun 2008

Many patients with heart failure miscalculate life expectancy

Many patients with heart failure - especially younger ones and those with more severe disease - significantly overestimate how long they going to live, say Duke University Medical Center researchers.

3 Jun 2008

How and where fat is stored predicts disease risk better than weight

Young adults who abuse amphetamines may be at greater risk of suffering a heart attack, UT Southwestern Medical Center researchers have found.

3 Jun 2008

How the cholesterol-lowering drug ezetimibe (Zetia) works

A new study in the June issue of Cell Metabolism, a Cell Press publication, sheds light on the action of the drug ezetimibe (trade name Zetia), which is used to treat high cholesterol. Ezetimibe is unique among cholesterol-lowering drugs in that it works by cutting the amount of cholesterol taken in from the diet rather than by blocking cholesterol's manufacture in the body.

3 Jun 2008

You may not be what you eat after all!

A new study shows that increased eating does not necessarily lead to increased fat. The finding in the much-studied roundworm opens the possibility of identifying new targets for drugs to control weight, the researchers say.

3 Jun 2008

Thinness versus obesity not directly linked to eating habits

Whether you are fat or thin isn't directly determined by your eating habits, suggest researchers who report new findings made in worms in the June issue of Cell Metabolism, a publication of Cell Press.

3 Jun 2008

New clues for nerve cell repair

A new study at the Montreal Neurological Institute at McGill University identifies a key mechanism for the normal development of motor nerve cells (motor neurons) - cells that control muscles. This finding is crucial to understanding and treating a range of conditions involving nerve cell loss or damage, from spinal cord injury to neurodegenerative diseases such as ALS, also known as Lou Gehrig's disease.

3 Jun 2008

Vigorous exercise helps seniors avoid disability

Healthy seniors who are physically active and exercise for more than 60 minutes each week can lessen their chances of disability as they age, finds a new long-term study.

3 Jun 2008

Bavarian Nordic enters trials with prostate cancer vaccine

Bavarian Nordic's subsidiary, BN ImmunoTherapeutics has initiated Phase I/II clinical studies with its therapeutic vaccine candidate against prostate cancer.

3 Jun 2008

Conversation helps people with dementia

Researchers in Britain conducting a study of people with dementia living in residential and nursing homes, say talking helps patients with dementia.

3 Jun 2008

CSL Behring study shows extended half-life recombinant VIIa leads to longer biologic activity

CSL Behring today presented results of a pre-clinical study that not only demonstrates the feasibility of genetically fusing factor VIIa to human albumin, but that this therapeutic protein with a prolonged half-life can lead to a longer biologic effect.

3 Jun 2008

ThromboGenics and BioInvent report positive results for anti-PlGF cancer therapeutic TB-403

ThromboGenics NV and co-development partner BioInvent International AB today reported that the results from the first Phase l study of novel anti-cancer agent TB-403 showed that it is safe and well tolerated, with pharmacokinetic properties enabling it to be developed for the treatment of cancer

3 Jun 2008

Paclitaxel Poliglumex/Capecitabine regimen well tolerated and active in metastatic breast cancer

At the 2008 Annual Meeting of the American Society of Clinical Oncology (ASCO), data were presented from a phase II investigator-sponsored trial paclitaxel poliglumex (Opaxio, CT-2103) in combination with capecitabine in first-line treatment of patients with metastatic breast cancer (MBC).

3 Jun 2008

Aggression between nursing-home residents more common than widely believed

When people hear about elder abuse in nursing homes, they usually think of staff members victimizing residents. However, research by Cornell University faculty members suggests that a more prevalent and serious problem may be aggression and violence that occurs between residents themselves.

2 Jun 2008

Preventable adverse events in hospitals occur 3 times more among patients with deafness, blindness or psychiatric disorders

Preventable adverse events in hospitals occur 3 times more often among patients with communication problems, such as deafness, blindness, psychiatric disorders and multiple health issues or comorbidities, found researchers in this study of nearly 2,400 patient records from 20 hospitals in Quebec.

2 Jun 2008

Cetuximab and chemotherapy combination proves safe, effective for head and neck cancer patients

Patients treated for locally advanced head and neck cancer may respond better to treatment with the addition of cetuximab to chemotherapy, according to a University of Pittsburgh Cancer Institute (UPCI) phase II study. The results will be presented at the 44th annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago as an oral presentation.

2 Jun 2008