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Optimal therapy for U.S. hepatitis C patients

As reported recently in the journal Hepatology, WIN-R, a multicenter study of over 5,000 patients with hepatitis C virus (HCV) showed treatment with weight-based REBETOL ribavirin, USP) (RBV) in combination with pegylated interferon (PEG-IFN) alfa-2b achieved significantly higher rates of sustained virologic response (SVR) and lower relapse rates compared to combination therapy using a flat dose of RBV 800 mg/day. Superior response was found particularly in patients with the most difficult-to-treat form of the disease, genotype 1 HCV. Efficacy was consistent across all weight groups.

28 Dec 2007

Health improves for previously uninsured adults after receiving Medicare coverage

Previously uninsured adults who received Medicare coverage reported improvements in health, especially those with cardiovascular disease or diabetes, according to a study in the December 26 issue of JAMA: The Journal of the American Medical Association.

28 Dec 2007

Chemotherapy and tamoxifen reduce risk of second breast cancer

Among breast cancer patients, both chemotherapy and tamoxifen independently reduced the risk of developing a second cancer in the other breast, according to a study published online December 25 in the Journal of the National Cancer Institute.

28 Dec 2007

Brief intervention helps emergency patients reduce drinking

Asking emergency department patients about their alcohol use and talking with them about how to reduce harmful drinking patterns is an effective way to lower rates of risky drinking in these patients, according to a nationwide collaborative study supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the Substance Abuse and Mental Health Services Administration (SAMHSA).

28 Dec 2007

Brain imaging shows there may be a cognitive difference in people with addictions

Scientists have for the first time identified brain sites that fire up more when people make impulsive decisions.

28 Dec 2007

Bevacizumab found to improve survival for patients with advanced breast cancer

Inhibiting the growth of blood vessels that supply tumors slows the progression of metastatic breast cancer according to results of a large clinical trial of Avastin, an anti-angiogenic therapy.

28 Dec 2007

Anthracyclines improve survival in HER2-positive breast cancer patients

Treatment with the class of chemotherapy drugs called anthracyclines improves survival in women with HER2-positive breast cancer who have previously had surgery, but it may not offer any benefit for women with HER2-negative tumors, according to a study published online December 25 in the Journal of the National Cancer Institute.

28 Dec 2007

Seniors who walk regularly lower their risk for dementia

Seniors who walk regularly and also do other forms of moderate exercise are protecting themselves against a certain form of dementia.

20 Dec 2007

Sex education works for teenagers and delays sexual intercourse

According to the latest research sex education in schools is effective and makes it more likely that teenagers will delay having intercourse.

20 Dec 2007

Vitamin B-12 function may be diminished by excessive folate

In a study of adults aged 20 and over, researchers at Tufts University showed that homocysteine and methylmalonic acid are at much higher levels in individuals who have a combination of vitamin B12 deficiency and high blood folate levels than in individuals who are also vitamin B12 deficient but have normal folate levels.

20 Dec 2007

Cannabis use among university students

New information published in the Journal of Applied Biobehavioral Research explores University students' motivations for using or not using cannabis and found various factors that might encourage use.

20 Dec 2007

Study finds outcomes of high-risk cancer operations in 80-year-olds worse than reported

New research published in the December issue of The Journal of the American College of Surgeons shows that outcomes of high-risk cancer operations in 80-year-olds are considerably worse than reported in case studies and published survival statistics, which may lead to unrealistic expectations about the safety of these operations in the elderly.

20 Dec 2007

Study examines computed tomographic pulmonary angiography for diagnosing blood clots in the lung

New research indicates that a diagnostic strategy using computed tomographic pulmonary angiography (CTPA) may be a safe alternative to conventional lungs scans (known as ventilation-perfusion scans) for excluding the diagnosis of pulmonary embolism (blood clots in the lung vessels), although CTPA may detect more clots, according to a study in the current issue of JAMA: The Journal of the American Medical Association.

20 Dec 2007

A new brain imaging study identifies 'brain signature' for cigarette cravings

A new brain imaging study by researchers in the Abramson Cancer Center of the University of Pennsylvania shows that cigarette cravings in smokers who are deprived of nicotine are linked with increased activation in specific regions of the brain.

20 Dec 2007

Hardening of the arteries - mutant gene identified as culprit

A genetic mutation expands lesions in the aorta and promotes coronary atherosclerosis, more commonly known as hardening of the arteries, according to a study by Yale School of Medicine in Cell Metabolism.

20 Dec 2007

Intensive training post-spinal cord injury can stimulate repair in brain and spinal cord

Intensive rehabilitation training for patients with spinal cord injuries can stimulate new branches growing from severed nerve fibers, alongside compensatory changes in the brain, say Canadian researchers.

20 Dec 2007

Study looks at prevalence of "false-positive" catheterization laboratory activation for patients with suspected STEMI

Physicians caring for patients suspected of having a heart attack may trigger "false-positive" activation of the cardiac catheterization laboratory based on test results suggestive of a heart attack, according to a study in the December 19 issue of JAMA: The Journal of the American Medical Association.

20 Dec 2007

Early surgical treatment contributes to better outcomes in gallstone pancreatitis cases

Although delaying surgical treatment remains the standard of care for patients with severe gallstone pancreatitis, a new study published in the December issue of the Journal of the American College of Surgeons shows that, contrary to widespread belief, early cholecystectomy -- or surgical removal of the gallbladder -- significantly reduces hospital stays in patients with mild to moderate gallstone pancreatitis with no increase in complications or mortality.

20 Dec 2007

Creative and challenging work helps people stay healthy

Employees who have more control over their daily activities and do challenging work they enjoy are likely to be in better health, according to a new study from The University of Texas at Austin published in this month's Journal of Health and Social Behavior.

20 Dec 2007

Rituximab may be promising treatment for diabetes

An antibody used to treat certain cancers and rheumatoid arthritis appears to greatly delay type 1 diabetes in mice, Yale School of Medicine researchers report in the Journal of Clinical Investigation.

20 Dec 2007

Drug Trial News

Optimal therapy for U.S. hepatitis C patients

Health improves for previously uninsured adults after receiving Medicare coverage

Chemotherapy and tamoxifen reduce risk of second breast cancer

Brief intervention helps emergency patients reduce drinking

Brain imaging shows there may be a cognitive difference in people with addictions

Bevacizumab found to improve survival for patients with advanced breast cancer

Anthracyclines improve survival in HER2-positive breast cancer patients

Seniors who walk regularly lower their risk for dementia

Sex education works for teenagers and delays sexual intercourse

Vitamin B-12 function may be diminished by excessive folate

Cannabis use among university students

Study finds outcomes of high-risk cancer operations in 80-year-olds worse than reported

Study examines computed tomographic pulmonary angiography for diagnosing blood clots in the lung

A new brain imaging study identifies 'brain signature' for cigarette cravings

Hardening of the arteries - mutant gene identified as culprit

Intensive training post-spinal cord injury can stimulate repair in brain and spinal cord

Study looks at prevalence of "false-positive" catheterization laboratory activation for patients with suspected STEMI

Early surgical treatment contributes to better outcomes in gallstone pancreatitis cases

Creative and challenging work helps people stay healthy

Rituximab may be promising treatment for diabetes

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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