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Test for LDH enzyme may help determine risk factors in sickle cell disease

Researchers have found that a simple test for an enzyme called LDH may have significant importance for determining major risk factors in adults with sickle cell disease.

9 Mar 2006

Metabolic switch required for cellular adaptation to hypoxia

Two new studies in the March Cell Metabolism reveal a survival mechanism by which cells adapt to oxygen starvation by ratcheting down their demand.

9 Mar 2006

Exposure to fine particle air pollution significantly increases the risk for cardiovascular and respiratory disease

New data from a four-year study of 11.5 million Medicare enrollees show that short-term exposure to fine particle air pollution from such sources as motor vehicle exhaust and power plant emissions significantly increases the risk for cardiovascular and respiratory disease among people over 65 years of age.

9 Mar 2006

Soy protein, almonds, plant sterol enriched margarines, oats and barley among most effective cholesterol-lowering foods

Cholesterol-lowering foods such as soy protein, almonds, plant sterol enriched margarines, oats and barley may reduce cholesterol levels more effectively when eaten in combination, says a new University of Toronto study by Professor David Jenkins.

9 Mar 2006

Third of adults are lonely!

More than a third of adults are lonely, with people in their forties suffering the highest levels, according to a study published in the latest Journal of Clinical Nursing.

8 Mar 2006

Relationship between periodonta treatment and overall cost of care for several diseases

Chronic conditions such as diabetes mellitus (DM), coronary artery disease (CAD), and cerebrovascular disease (CVD) have been associated with periodontal disease.

8 Mar 2006

Primary vesicoureteral reflux detected in neonates with a history of fetal renal pelvis dilatation

Fetal renal pelvis dilatation is a common abnormality, observed in 4.5% of pregnancies but surrounded by controversy regarding its significance. Working up renal pelvis dilation has become a standard of care regardless of the presence or absence of symptoms with vesicoureteral reflux (VUR) being one of the primary concerns.

8 Mar 2006

Is there any role for thalidomide as a monotherapy in the management of metastatic renal cell carcinoma?

Thalidomide remains an enigma in the treatment of metastatic renal cell carcinoma (RCC). Initial clinical trials suggested a benefit, but more recently, subsequent randomized trials studying thalidomide in combination with other agents such as interferon have demonstrated no added benefit.

8 Mar 2006

Short-term exposure to fine particulate matter increases hospital admissions for heart problems

Short-term exposure to fine particulate matter - the microscopic particles that pollute the air - increased hospital admissions for cardiovascular and respiratory disease among Medicare participants, according to a study of 204 U.S. urban counties conducted by researchers at the Johns Hopkins Bloomberg School of Public Health and Yale University’s environment school.

8 Mar 2006

Coffee good or bad for you? It depends on your genes!

Scientists know that coffee, a major source of caffeine, is metabolized by the enzyme, cytochrome P450 1A2, and some individuals who have that particular gene are "rapid" caffeine metabolizers, whereas those with a different variation of the gene are "slow" caffeine metabolizers.

8 Mar 2006

Is partial nephrectomy oncologically safe for tumors greater than 4cm?

Traditionally, nephron sparing surgery in the presence of a normal contralateral kidney is primarily advocated for tumors <= 4cm.

7 Mar 2006

Clinical implication of routine stone culture in percutaneous nephrolithotomy - A prospective study

If you have a patient with a staghorn stone and the preoperative urine culture is sterile, does that mean that the stone is likewise sterile? The answer is No.

7 Mar 2006

MannKind initiates two phase 3 studies of inhaled Technosphere insulin

MannKind Corporation has announced that it has initiated patient enrollment in two pivotal 12-month Phase 3 clinical trials of Technosphere Insulin (TI) in patients with Type 1 and Type 2 Diabetes.

7 Mar 2006

Discovery of compound that reduces hallmark lesions of Alzheimer's disease in mice

Researchers at UC Irvine have found that a new compound not only relieves the cognitive symptoms of Alzheimer's disease, but also reduces the two types of brain lesions that are hallmarks of this devastating disease, thereby blocking its progression.

7 Mar 2006

Validation of cardiovascular risk scores in a liver transplant population

Two methods of assessing a patient's risk of cardiovascular events - SCORE and PROCAM - proved more valuable for liver transplant recipients than an alternative method, according to a new study.

7 Mar 2006

Study may lead to ways to reduce heart attacks in diabetes patients

For people with type 2 diabetes, the death rate from a first heart attack is two to three times the death rate of patients without the disease. Similarly, patients with diabetes and ischemic (reduced blood flow) heart disease have a much higher mortality rate than the general population.

7 Mar 2006

Gene therapy approach used in creating new arteries for older patients does not appear to cause cancer

"This result is an encouraging step along the road to new tissues for patients to replace those that have failed or have been destroyed due to trauma or disease," she said.

7 Mar 2006

Study looks at how two forms of vitamin E affect the health of animal cells

One of the most powerful antioxidants is truly a double-edged sword, say researchers at Ohio State University who studied how two forms of vitamin E act once they are inside animal cells.

7 Mar 2006

Omega-3 polyunsaturated fatty acids may influence mood, personality and behavior

In a study of 106 healthy volunteers, researchers found that participants who had lower blood levels of omega-3 polyunsaturated fatty acids were more likely to report mild or moderate symptoms of depression, a more negative outlook and be more impulsive.

7 Mar 2006

A less active brain serotonin system is associated with early hardening of the arteries

These findings, which are the first to establish a link between serotonin messages in the brain and atherosclerosis, could lead to an entirely new strategy for preventing heart disease and stroke, say the researchers.

7 Mar 2006

Drug Trial News

Test for LDH enzyme may help determine risk factors in sickle cell disease

Metabolic switch required for cellular adaptation to hypoxia

Exposure to fine particle air pollution significantly increases the risk for cardiovascular and respiratory disease

Soy protein, almonds, plant sterol enriched margarines, oats and barley among most effective cholesterol-lowering foods

Third of adults are lonely!

Relationship between periodonta treatment and overall cost of care for several diseases

Primary vesicoureteral reflux detected in neonates with a history of fetal renal pelvis dilatation

Is there any role for thalidomide as a monotherapy in the management of metastatic renal cell carcinoma?

Short-term exposure to fine particulate matter increases hospital admissions for heart problems

Coffee good or bad for you? It depends on your genes!

Is partial nephrectomy oncologically safe for tumors greater than 4cm?

Clinical implication of routine stone culture in percutaneous nephrolithotomy - A prospective study

MannKind initiates two phase 3 studies of inhaled Technosphere insulin

Discovery of compound that reduces hallmark lesions of Alzheimer's disease in mice

Validation of cardiovascular risk scores in a liver transplant population

Study may lead to ways to reduce heart attacks in diabetes patients

Gene therapy approach used in creating new arteries for older patients does not appear to cause cancer

Study looks at how two forms of vitamin E affect the health of animal cells

Omega-3 polyunsaturated fatty acids may influence mood, personality and behavior

A less active brain serotonin system is associated with early hardening of the arteries

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

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