Genomics

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UTHSC professor recognized for contributions to pioneering cancer genomic research

Neil Hayes, MD, MS, MPH, division chief of Hematology and Oncology at the University of Tennessee Health Science Center, is among recipients of the 2020 Team Science Awards from the American Association for Cancer Research for his contributions to developing The Cancer Genome Atlas, a groundbreaking multisite project to understand cancer at its molecular level through genome sequencing and extensive data analysis.

7 Aug 2020

Research identifies a potential therapeutic target for clogged arteries

New work led by Carnegie's Meredith Wilson and Steve Farber identifies a potential therapeutic target for clogged arteries and other health risks that stem from an excess of harmful fats in the bloodstream. Their findings are published by PLOS Genetics.

7 Aug 2020

New approach improves SCA1 symptoms in animal models

Research has shown that a mutation in the ATAXIN-1 gene leads to accumulation of Ataxin-1 (ATXN1) protein in brain cells and is the root cause of a rare genetic neurodegenerative disease known as spinocerebellar ataxia type 1 (SCA1).

7 Aug 2020

Study: Early training of cell development and network improves response

When it comes to training neural circuits for tissue engineering or biomedical applications, a new study suggests a key parameter: Train them young.

7 Aug 2020

Researchers develop a deep learning-based algorithm for predicting sites of DNA methylation

A team of researchers from New Jersey Institute of Technology and Children's Hospital of Philadelphia have developed an algorithm through machine learning that helps predict sites of DNA methylation - a process that can change the activity of DNA without changing its overall structure - and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods.

6 Aug 2020

Genetic variation influencing chromatin states associated with neuropsychiatric disorders

A new study led by NorthShore University HealthSystem and the University of Chicago took a novel approach to identifying SNPs influencing the risk of neuropsychiatric disorders like schizophrenia, bipolar and major depressive disorder, the institutions announced today.

4 Aug 2020

Regulatory mechanisms involved in brain development are same for insects and mammals

With these new findings scientists can potentially better understand the subtle changes that can occur in genes and brain circuits that can lead to mental health disorders such as anxiety and autism spectrum disorders.

4 Aug 2020

New method reveals the dynamics of cell development and gene activity

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only rather than time-lapse films.

4 Aug 2020

Scientists identify robust set of biomarkers to help guide treatment for brain injuries

A scientific team led by the University of Arizona and the Translational Genomics Research Institute, an affiliate of City of Hope, identified a robust set of biomarkers through proteomics and metabolomic analysis that could help guide treatment for tens of millions of patients who each year sustain brain injuries, potentially preventing severe long-term disabilities.

3 Aug 2020

Researchers use human genome database to study cancer cells

Florida State University Professor of Biological Science David Gilbert is using the latest information about the human genome as a guide to better understand cancer.

30 Jul 2020

Researchers are developing comprehensive catalog of functional elements of human and mouse genomes

Scientists around the world have access to a rich trove of information through the Encyclopedia of DNA Elements (ENCODE)--annotated versions of the human and mouse genomes that are vital for interpreting their genetic codes.

30 Jul 2020

UC San Diego researchers part of special package of human genome studies

Researchers at University of California San Diego School of Medicine are among the contributors to a package of 10 studies, published July 29, 2020 in the journal Nature, describing the latest results from the ongoing Encyclopedia of DNA Elements (ENCODE) project, a worldwide effort led by the National Institutes of Health to understand how the human genome functions.

29 Jul 2020

Study finds fungal isolates with high levels of virulence in different hospitals

A group of researchers from Brazil, Denmark, Italy and Spain analyzed 884 samples of fungi of the genus Candida collected from 16 hospitals and found a significant number of clusters in more than one hospital.

29 Jul 2020

New maps of chemical marks on DNA could help illuminate the causes of developmental disorders

In research that aims to illuminate the causes of human developmental disorders, Salk scientists have generated 168 new maps of chemical marks on strands of DNA--called methylation--in developing mice.

29 Jul 2020

Human genome may explain the neonatal origins of chronic immune and inflammatory diseases

A study published in the journal Nature Communications has pinpointed a number of areas of the human genome that may help explain the neonatal origins of chronic immune and inflammatory diseases of later life, including type 1 diabetes, rheumatoid arthritis and coeliac disease.

28 Jul 2020

Simultaneous mutation of two nonessential genes can cause cancer cell death

A Ludwig Cancer Research study has identified a new instance in which the simultaneous mutation of two nonessential genes - neither of which is on its own vital to cell survival - can cause cancer cell death.

28 Jul 2020

New strategy may help guard beta cells, slow the onset of type 1 diabetes

Type 1 diabetes occurs when a person's own immune system destroys insulin-producing beta cells in the pancreas. In recent years, scientists have learned how to grow large volumes of replacement beta cells, but the researchers are still trying out many options to protect these cells against the immune attack.

27 Jul 2020

Population screening has potential to identify individuals at risk for inherited genetic conditions

In a new study published today in the journal Nature Medicine, researchers behind the Healthy Nevada Project® suggest that community-based genetic screening has the potential to efficiently identify individuals who may be at increased risk for three common inherited genetic conditions known to cause several forms of cancer and increased risk for heart disease or stroke.

27 Jul 2020

EBV viral genome alters the host epigenetic landscape to drive stomach cancer

The Epstein-Barr virus (EBV), one of the most common human viruses, is associated with about 8-10 per cent of stomach -- or gastric -- cancers, the third leading cause of cancer death globally.

27 Jul 2020

Researchers use optogenetics to activate and inactivate signaling pathways

Proper embryonic development of the fruit fly Drosophila melanogaster is governed by patterns of protein activity bequeathed to the fertilized egg by its mother.

24 Jul 2020

Genomics

UTHSC professor recognized for contributions to pioneering cancer genomic research

Research identifies a potential therapeutic target for clogged arteries

New approach improves SCA1 symptoms in animal models

Study: Early training of cell development and network improves response

Researchers develop a deep learning-based algorithm for predicting sites of DNA methylation

Genetic variation influencing chromatin states associated with neuropsychiatric disorders

Regulatory mechanisms involved in brain development are same for insects and mammals

New method reveals the dynamics of cell development and gene activity

Scientists identify robust set of biomarkers to help guide treatment for brain injuries

Researchers use human genome database to study cancer cells

Researchers are developing comprehensive catalog of functional elements of human and mouse genomes

UC San Diego researchers part of special package of human genome studies

Study finds fungal isolates with high levels of virulence in different hospitals

New maps of chemical marks on DNA could help illuminate the causes of developmental disorders

Human genome may explain the neonatal origins of chronic immune and inflammatory diseases

Simultaneous mutation of two nonessential genes can cause cancer cell death

New strategy may help guard beta cells, slow the onset of type 1 diabetes

Population screening has potential to identify individuals at risk for inherited genetic conditions

EBV viral genome alters the host epigenetic landscape to drive stomach cancer

Researchers use optogenetics to activate and inactivate signaling pathways

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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