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NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

Natural killer (NK) cells derived from cord blood that were activated and complexed with a CD30/CD16A bispecific antibody elicited an 89 percent overall response rate in patients with relapsed or refractory CD30+ lymphoma, according to results from a phase I/II clinical trial presented at the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Patients with non-small cell lung cancer (NSCLC) treated with the KRAS G12C inhibitor sotorasib (Lumakras) had a two-year overall survival rate of 32.5 percent, according to data from the CodeBreaK 100 clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Preliminary data from clinical trial reveals safety, efficacy of new CAR T-cell therapy for solid tumors

A new chimeric antigen receptor (CAR) T-cell product had an acceptable safety profile and showed early signs of efficacy as a monotherapy and in combination with an mRNA vaccine in patients with solid tumors, according to preliminary data from a phase I/II clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Consumption of healthy plant-based foods linked with lower risk of developing type 2 diabetes

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) finds that the consumption of healthy plant-based foods, including fruits, vegetables, nuts, coffee, and legumes, is associated with a lower risk of developing type 2 diabetes (T2D) in generally healthy people and support their role in diabetes prevention.

10 Apr 2022

Novel therapy advances to clinical trial for the treatment of glioblastoma

A novel therapy studied at the Medical College of Wisconsin (MCW) Cancer Center has led to a clinical trial for the treatment of glioblastoma, a rare and aggressive form of brain cancer, yet the most common primary brain tumor in adults.

10 Apr 2022

Simple interventions reduced radiation exposure to the heart during lung cancer treatment

Radiation to the heart during treatment for locally advanced lung cancer is associated with an increased risk of major adverse cardiac events within the first two years following treatment. The higher the cardiac dose exposure, the higher the risk of a cardiac event.

8 Apr 2022

Cancer risk and related mortality significantly higher among patients with kidney disease

Patients with kidney disease may have an increased risk of cancer and may be more likely to die from cancer.

8 Apr 2022

Imbalances in the intestinal virome may promote inflammatory bowel disease, research shows

Research in recent years has demonstrated the diverse roles that gut bacteria can play in health and disease, but what about contributions from viruses, which, like bacteria, perpetually reside within the human intestine?

8 Apr 2022

New delivery method enhances the "attack power" of CAR T cells against tumors

One cutting-edge cancer treatment exciting researchers today involves collecting and reprogramming a patient's T cells – a special set of immune cells – then putting them back into the body ready to detect and destroy cancerous cells.

8 Apr 2022

Combination immunotherapy reverses resistance to PD-1 inhibitors in patients with advanced melanoma

Patients with advanced melanoma whose cancer does not respond to treatment with widely used immunotherapy drugs known as PD-1 inhibitors are often switched to treatment with a second type of immunotherapy drug – a CTLA-4 inhibitor such as the drug ipilimumab.

8 Apr 2022

City of Hope's late-breaking clinical trial data to be presented at AACR

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, will present late-breaking and clinical trial findings at this year's American Association for Cancer Research Annual Meeting, which begins today.

8 Apr 2022

Artificial intelligence model could predict side effects resulting from new combination therapies

Preliminary data from an artificial intelligence model could potentially predict side effects resulting from new combination therapies, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

8 Apr 2022

AI model uses electronic health records to identify people at high risk for pancreatic cancer

An artificial intelligence (AI) model trained using sequential health information derived from electronic health records identified a subset of individuals with a 25-fold risk of developing pancreatic cancer within three to 36 months, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

8 Apr 2022

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

On Thursday, April 7, the Centers for Medicare and Medicaid (CMS) formalized its plan to cover the anti-amyloid drug Aduhelm only for patients enrolled in clinical trials.

8 Apr 2022

Researchers discover new mechanisms for bone loss in gum disease

Tokyo University of Agriculture and Technology researchers reported on a new discovery regarding the mechanisms for bone loss in gum disease (periodontitis). They found that double stranded RNA molecules can activate the immune system response that leads to deterioration of bone.

8 Apr 2022

New Alzheimer’s disease hypothesis could open up diagnosis or treatment possibilities

Alzheimer's Disease could be caused by damage to a protective barrier in the body that allows fatty substances to build up in the brain, newly published research argues.

8 Apr 2022

Expanding statin prescription could be a cost-effective intervention against cardiovascular disease

Expanding prescription of statin medication to reduce low-density lipoprotein cholesterol could be a cost-effective intervention against cardiovascular disease, according to a Northwestern Medicine study published in the journal Circulation.

8 Apr 2022

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

New findings from the ongoing Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study suggest that certain rheumatoid arthritis drugs may lower incidence of Alzheimer's disease and related dementias in people with cardiovascular disease.

8 Apr 2022

Depressive disorders are associated with general increase in the deformability of immune cells

A recent study by the TU Dresden and the University of Zurich in cooperation with the Max Planck Institute for the Science of Light establishes for the first time a link between depressive disorders and mechanical characteristics of all major blood cell types.

8 Apr 2022

Nanomedicine for treating life-threatening brain tumors

Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka) has announced that Dr. Sabina Quader et al. published a review article focusing on the recent nanomedicines for brain cancers on Advanced Drug Delivery Review in this March.

8 Apr 2022

Medical Condition News

NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Preliminary data from clinical trial reveals safety, efficacy of new CAR T-cell therapy for solid tumors

Consumption of healthy plant-based foods linked with lower risk of developing type 2 diabetes

Novel therapy advances to clinical trial for the treatment of glioblastoma

Simple interventions reduced radiation exposure to the heart during lung cancer treatment

Cancer risk and related mortality significantly higher among patients with kidney disease

Imbalances in the intestinal virome may promote inflammatory bowel disease, research shows

New delivery method enhances the "attack power" of CAR T cells against tumors

Combination immunotherapy reverses resistance to PD-1 inhibitors in patients with advanced melanoma

City of Hope's late-breaking clinical trial data to be presented at AACR

Artificial intelligence model could predict side effects resulting from new combination therapies

AI model uses electronic health records to identify people at high risk for pancreatic cancer

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

Researchers discover new mechanisms for bone loss in gum disease

New Alzheimer’s disease hypothesis could open up diagnosis or treatment possibilities

Expanding statin prescription could be a cost-effective intervention against cardiovascular disease

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

Depressive disorders are associated with general increase in the deformability of immune cells

Nanomedicine for treating life-threatening brain tumors

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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