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Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Oncotarget published "Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis" which reported that microscopic imaging, immunocytochemistry, wound healing assay, caspase-cleaved cytokeratin 18 CytoDeath ELISA assay, immunofluorescence labeling assays for apoptosis, hypoxia, Western Blotting, Tunnel assay, measurement of 5-HT secretion by carbon fiber amperometry assay, quantitative methylation-specific PCR, morphologic changes, cell viability, apoptosis activity and the expression levels of phospho-Akt1, Akt1, HIF-1α, PI3K, p21, CAIX, 5-HT, phospho-mTOR, and mTOR in xenografts derived from typical H727 and atypical H720 BC cell lines.

28 Aug 2021

Exercise reduces the amount of calories burned at rest in obese people, study finds

Exercise reduces the amount of calories burned at rest in people with obesity, according to a new study by researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences and the University of Roehampton.

28 Aug 2021

Study may pave way for new treatment strategies to limit the progression of solid tumors

Researchers at the University of British Columbia's faculty of medicine and BC Cancer Research Institute have uncovered a weakness in a key enzyme that solid tumour cancer cells rely on to adapt and survive when oxygen levels are low.

28 Aug 2021

Mobile telemedicine unit found to be effective in treating opioid use disorder in rural areas

Rural regions in the U.S. have been disproportionately affected by the opioid epidemic, while also having the fewest number of programs to treat opioid use disorder.

28 Aug 2021

Exoskeleton-assisted rehabilitation can help treat stroke survivors

Exoskeleton-assisted rehabilitation can be beneficial in treating stroke survivors, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).

28 Aug 2021

NYU Tandon describes novel peptide with broad therapeutic potential to combat multiple diseases

NYU Tandon professors Mary Cowman and Jin Ryoun Kim recently published a paper describing a novel peptide with broad therapeutic potential to combat chronic inflammation in multiple diseases.

28 Aug 2021

Implantable cardiac monitors effectively detect serious arrhythmias in selected post-infarction patients

Remote monitoring of implantable cardiac monitors (ICMs) is highly effective for early detection of serious arrhythmias in high-risk post-infarction patients with cardiac autonomic dysfunction and moderately reduced ejection fraction.

27 Aug 2021

$Analysis shows benefits of empagliflozin in heart failure patients with reduced and preserved ejection fraction$

Analysis shows benefits of empagliflozin in heart failure patients with reduced and preserved ejection fraction

A pooled analysis of two randomized trials has demonstrated the beneficial effects of empagliflozin in patients with heart failure with a reduced and preserved ejection fraction. The late breaking study is presented in a Hot Line session today at ESC Congress 2021 and published in the New England Journal of Medicine.

27 Aug 2021

Hemodynamic-guided management may reduce hospitalizations in patients with earlier stage heart failure

Hemodynamic guided management may reduce heart failure hospitalizations in patients with earlier stage heart failure, according to late breaking research presented in a Hot Line session today at ESC Congress 2021 and published in The Lancet.

27 Aug 2021

People living in greener areas less likely to develop cardiovascular disease

People who live in green neighborhoods are less likely to develop cardiovascular disease, according to research presented at ESC Congress 2021.

27 Aug 2021

Light-to-moderate coffee drinking linked to lower risk of stroke and fatal heart disease

Up to three cups of coffee per day is associated with a lower risk of stroke and fatal heart disease, according to research presented at ESC Congress 2021.

27 Aug 2021

Smoking cessation more likely to improve mood in heart attack survivors

Smokers with depression at the time of a heart attack who quit smoking are more likely to improve their mood than those who continue the habit. That's the finding of research presented at ESC Congress 2021.

27 Aug 2021

Ultra-processed food intake linked to increased risk of heart disease

Weekly consumption of ultra-processed food is linked with an increased risk of heart disease, according to research presented at ESC Congress 2021.

27 Aug 2021

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

The National Institutes of Health has begun a clinical trial to assess the antibody response to an extra dose of an authorized or approved COVID-19 vaccine in people with autoimmune disease who did not respond to an original COVID-19 vaccine regimen.

27 Aug 2021

FDA approves drug-free stroke rehabilitation system to treat upper extremity motor deficits

The U.S. Food and Drug Administration today approved the MicroTransponder Vivistim Paired VNS System (Vivistim System), a first-of-its-kind, drug-free rehabilitation system intended to treat moderate to severe upper extremity motor deficits associated with chronic ischemic stroke—a stroke caused by a blockage of blood flow to the brain with long-lasting symptoms—using vagus nerve stimulation (VNS).

27 Aug 2021

New ESC guidelines for diagnosis and treatment of heart failure published

The European Society of Cardiology Guidelines for the diagnosis and treatment of acute and chronic heart failure are published online today in European Heart Journal.

27 Aug 2021

Drones flew defibrillators to location of patients with suspected cardiac arrest, study reports

Researchers at Karolinska Institutet in Sweden can now report the results of a unique pilot project where drones were used to deliver defibrillators to real-life alerts of suspected cardiac arrest.

27 Aug 2021

Post-traumatic stress symptoms in COVID-19 survivors linked with changes to the brain's connectivity

COVID-19 survivors report significantly higher symptoms of post-traumatic stress, and these symptoms are associated with changes to the brain's connectivity, according to a study coauthored by Vince Calhoun, Distinguished Professor of Psychology at Georgia State University and director of the Center for Translational Research in Neuroimaging and Data Science (TReNDS).

27 Aug 2021

Study identifies link between common air pollutants and incidence of cardiac arrest

A study in Italy has identified a dose-response relationship between the concentration of everyday pollutants and the incidence of out-of-hospital cardiac arrest. The research is presented at ESC Congress 2021.

27 Aug 2021

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

A Phase 2 trial led by City of Hope, a world-renowned research and treatment center for cancer and diabetes, suggests that adding the novel ataxia telangiectasia and Rad3-related (ATR) inhibitor drug berzosertib to standard-of-care chemotherapy for patients with metastatic urothelial cancer does not extend progression-free survival.

27 Aug 2021

Medical Condition News

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Exercise reduces the amount of calories burned at rest in obese people, study finds

Study may pave way for new treatment strategies to limit the progression of solid tumors

Mobile telemedicine unit found to be effective in treating opioid use disorder in rural areas

Exoskeleton-assisted rehabilitation can help treat stroke survivors

NYU Tandon describes novel peptide with broad therapeutic potential to combat multiple diseases

Implantable cardiac monitors effectively detect serious arrhythmias in selected post-infarction patients

Analysis shows benefits of empagliflozin in heart failure patients with reduced and preserved ejection fraction

Hemodynamic-guided management may reduce hospitalizations in patients with earlier stage heart failure

People living in greener areas less likely to develop cardiovascular disease

Light-to-moderate coffee drinking linked to lower risk of stroke and fatal heart disease

Smoking cessation more likely to improve mood in heart attack survivors

Ultra-processed food intake linked to increased risk of heart disease

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

FDA approves drug-free stroke rehabilitation system to treat upper extremity motor deficits

New ESC guidelines for diagnosis and treatment of heart failure published

Drones flew defibrillators to location of patients with suspected cardiac arrest, study reports

Post-traumatic stress symptoms in COVID-19 survivors linked with changes to the brain's connectivity

Study identifies link between common air pollutants and incidence of cardiac arrest

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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