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Study reveals why Alzheimer's drugs fail in clinical trials

A tremendous amount of Amyloid-β peptide (Aβ) (a peptide of ～40 amino acids) accumulates in the brain of Alzheimer's disease patients. γ-Secretase inhibitors were designed to inhibit the enzymatic activity that produces Aβ. By reducing Aβ production, γ-secretase inhibitors were considered able to treat Alzheimer's disease (Aβ hypothesis).

25 Oct 2017

Long-term risk of premature death in men and women strongly associated with depression, study reveals

A Stirling County study, published in Canadian Medical Association Journal, suggests that depression remains strongly associated with a higher risk of early death in both men and women.

25 Oct 2017

Researchers discover mechanism that corrects protein misfolding in plants

Various human nervous system diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer's, Huntington's, and Parkinson's diseases, are associated with the same basic disorder: the loss of nerve cells capacity to fold their proteins correctly, which causes protein aggregations that form "clumps" that end up generating the cell death.

25 Oct 2017

Hospitals need to improve emergency care practices for treating older cancer patients, study reveals

A new study finds that patients with cancer, especially those aged 75 or older, are more likely to be admitted to the hospital – and less likely to be observed and released home – than patients without cancer.

25 Oct 2017

Research identifies molecular mechanism that causes kidney cancer to resist drug treatment

New research from The University of Texas Health Science Center at San Antonio and U.S. Department of Veterans Affairs has identified the molecular mechanism that causes kidney cancer to resist drug treatment.

25 Oct 2017

Proton beam therapy can help improve outcomes in elderly patients with esophageal cancer

A study led by Mayo Clinic researchers has found that proton beam therapy, in combination with chemotherapy, prior to surgery, may be a better option than a combination using traditional radiation therapy techniques with chemotherapy when treating elderly patients with esophageal cancer.

25 Oct 2017

Scientists get one step closer to reversing retinal degenerative diseases

Degenerative disorders affecting the retinal pigment epithelium (RPE), such as age-related macular degeneration and autosomal recessive bestrophinopathy, can ultimately lead to blindness. Some of these life-changing disorders are the result of mutations in a single gene, called BEST1.

25 Oct 2017

New set of guidelines released for managing and caring patients with mitochondrial disease

Physicians who see patients with mitochondrial disease now have a practical new tool--a set of guidelines for managing and caring for those patients.

25 Oct 2017

Weight loss following bariatric operation leads to improvements in heart health

In overweight and obese people, fat often gets deposited in the midsection of the body. Large amounts of this belly fat can lead to unhealthy changes in a heart's function and size.

25 Oct 2017

Stony Brook University scientist receives $3.9 million NIH grant for ALS research

Stony Brook University scientist Josh Dubnau, PhD, has received a $3.9 million grant from the National Institutes of Health to investigate the impact of environmental stressors and other external factors that contribute to the development of amyotrophic lateral sclerosis (ALS).

24 Oct 2017

Case report of a 21 year old woman sweating blood

She had a rare condition called hematohidrosis where she was sweating blood and her tears too contained blood. The dermatologists published the report of her rare case while protecting her identity, this week in the Canadian Medical Association Journal.

24 Oct 2017

Fight CRC and CRI announce publication of ‘A Blueprint to Advance Colorectal Cancer Immunotherapies’

Fight Colorectal Cancer and the Cancer Research Institute, are proud to announce "A Blueprint to Advance Colorectal Cancer Immunotherapies" will be published in the November 2017 issue of the journal Cancer Immunology Research (published online ahead of print on October 16, 2017).

24 Oct 2017

Myelin sheaths restore impaired nervous system over the long haul

In the central nervous system of humans and all other mammals, a vital insulating sheath composed of lipids and proteins around nerve fibers helps speed the electrical signals or nerve impulses that direct our bodies to walk, talk, breathe, swallow or perform any routine physical act.

24 Oct 2017

Depression among nurses may increase likelihood of medical errors

Depression is common among nurses and is linked to a higher likelihood they'll make medical errors, new research suggests.

24 Oct 2017

APC gene mutations play dual role in development of colorectal cancer, research suggests

Adenomatous polyposis coli (APC) is a gene whose mutations are associated with a rare, hereditary form of colorectal cancer known as familial adenomatous polyposis. Research led by scientists at the Institut Pasteur and Inserm have recently demonstrated that mutations to this gene do not only lead to the emergence of colon polyps; they also harm the immune system, leaving it unable to tackle inflammation of the colonic mucosa.

24 Oct 2017

Study explores role of genes in depression vulnerability

In the current issue of Psychotherapy and Psychosomatics a study explored the role of genes in depression vulnerability. The financial crisis that has afflicted Greece since 2008 has adversely affected the physical and mental health of the population, with reports pointing to a rise in the prevalence of depression from 3.3% prior to the crisis to 12.3% in 2013.

24 Oct 2017

Researchers evaluate potential of stem cells, therapeutic agents in neurodegenerative diseases

As the brain has limited capability for self-repair or regeneration, stem cells may represent the best therapeutic approach for counteracting damage to or degeneration of brain tissue caused by injury, aging, or disease.

24 Oct 2017

Increasing the dosage of antidepressants does not carry benefits, analysis reveals

In the current issue of Psychotherapy and Psychosomatics a new analysis discloses that increasing the dosage of antidepressant drugs does not carry benefits. As many patients with unipolar depression do not respond sufficiently to initial antidepressant monotherapy, a dose increase of the current administered antidepressant (dose escalation, high-dose treatment) is frequently carried out as next treatment measure.

24 Oct 2017

Study explores mechanisms of psychotherapy in individuals at very high risk of psychosis

In the current issue of Psychotherapy and Psychosomatics a study explores the mechanisms of psychotherapy in subjects at very high risk of psychosis. Cognitive-behavioral therapy (CBT) is the first-choice treatment in clients with ultra-high risk (UHR) for psychosis.

24 Oct 2017

New analysis reveals insights into long-term effects of antidepressant drugs

In the current issue of Psychotherapy and Psychosomatics a new analysis discloses insights into the long term effects of antidepressant drugs. Major depressive disorder (MDD) is more often chronic or recurrent in clinical than in community samples.

24 Oct 2017

Medical Condition News

Study reveals why Alzheimer's drugs fail in clinical trials

Long-term risk of premature death in men and women strongly associated with depression, study reveals

Researchers discover mechanism that corrects protein misfolding in plants

Hospitals need to improve emergency care practices for treating older cancer patients, study reveals

Research identifies molecular mechanism that causes kidney cancer to resist drug treatment

Proton beam therapy can help improve outcomes in elderly patients with esophageal cancer

Scientists get one step closer to reversing retinal degenerative diseases

New set of guidelines released for managing and caring patients with mitochondrial disease

Weight loss following bariatric operation leads to improvements in heart health

Stony Brook University scientist receives $3.9 million NIH grant for ALS research

Case report of a 21 year old woman sweating blood

Fight CRC and CRI announce publication of ‘A Blueprint to Advance Colorectal Cancer Immunotherapies’

Myelin sheaths restore impaired nervous system over the long haul

Depression among nurses may increase likelihood of medical errors

APC gene mutations play dual role in development of colorectal cancer, research suggests

Study explores role of genes in depression vulnerability

Researchers evaluate potential of stem cells, therapeutic agents in neurodegenerative diseases

Increasing the dosage of antidepressants does not carry benefits, analysis reveals

Study explores mechanisms of psychotherapy in individuals at very high risk of psychosis

New analysis reveals insights into long-term effects of antidepressant drugs

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

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