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Study may provide insight into how R-LA promotes death of hepatoma cells

A new study that measured metabolite levels over time in starved rat liver cancer cells showed that treatment with a form of alpha-lipoic acid (LA) inhibited glucose uptake and glycolysis, and led to decreased cellular glucose production from non-carbohydrate sources, which may help explain how the naturally occurring R enantiomeric form of LA (R-LA) promotes the death of hepatoma cells.

12 Apr 2017

Point/Counterpoint: Experts debate how to control exploding opioid epidemic

Two experts with opposing views squared off on the hotly debated topic of how best to control the exploding opioid epidemic in the U.S.- with increasing regulation of physician prescribing practices or by better educating patients and doctors.

12 Apr 2017

Disability simulations do more harm than good, study reveals

Professionals in the fields of education and rehabilitation psychology have long used disability simulations to try to promote understanding and improve attitudes about persons with disabilities.

12 Apr 2017

Researchers explore patient adherence, tolerability to class of Alzheimer's drugs

Researchers from the Indiana University Center for Aging Research and the Regenstrief Institute have performed the first study conducted in the United States under real-world conditions comparing patient adherence and tolerability to a class of drugs known as cholinesterase inhibitors.

11 Apr 2017

PID1 gene increases killing effect of chemotherapy drugs on brain tumor cells

Investigators at The Saban Research Institute of Children's Hospital Los Angeles have found that the gene PID1 enhances killing of medulloblastoma and glioblastoma cells.

11 Apr 2017

Researchers use genetic manipulation to regenerate auditory hair cells in adult mice

In an apparent first, St. Jude Children's Research Hospital investigators have used genetic manipulation to regenerate auditory hair cells in adult mice. The research marks a possible advance in treatment of hearing loss in humans. The study appears today in the journal Cell Reports.

11 Apr 2017

Scientists discover novel therapeutic target for retinal neovascularization

A team led by Massachusetts Eye and Ear researchers has identified a novel therapeutic target for retinal neovascularization, or abnormal blood vessel growth in the retina, a hallmark of advanced diabetic eye disease (proliferative diabetic retinopathy).

11 Apr 2017

FDA grants approval for first drug to treat adults with tardive dyskinesia

The U.S. Food and Drug Administration today approved Ingrezza (valbenazine) capsules to treat adults with tardive dyskinesia. This is the first drug approved by the FDA for this condition.

11 Apr 2017

New nanowire technology may serve as platform to screen drugs for neurological diseases

A team led by engineers at the University of California San Diego has developed nanowires that can record the electrical activity of neurons in fine detail.

11 Apr 2017

Feinstein Institute research may lead to new treatment option for low-grade gliomas

Marc Symons, PhD, professor in The Feinstein Institute for Medical Research's Karches Center for Oncology Research, is examining if a common medication administered to treat pinworms, could replace the current treatment used for certain brain cancers.

11 Apr 2017

Duke researchers link specific differences in brain structure to multiple forms of mental disorder

A Duke University study is the first to link specific differences in brain structure to what is common across many types of mental illness.

11 Apr 2017

Western-led research uncovers underlying molecular mechanism that controls acoustic habituation

Most people will startle when they hear an unexpected loud sound. The second time they hear the noise, they'll startle significantly less; by the third time, they'll barely startle at all.

11 Apr 2017

JAX professor receives grant from National Eye Institute to study diseases of retinal pigment epithelium

The National Eye Institute has awarded Jackson Laboratory Professor Patsy Nishina, Ph.D., and Associate Professor Gregory Carter, Ph.D., a four-year grant totaling $2,414,304 to study diseases of the retinal pigment epithelium (RPE), with the goal of identifying druggable targets for age-related macular degeneration and other heritable retinal diseases.

11 Apr 2017

Researchers design first light-activated drug for treatment of pain

A team of the Institute of Neurosciences of the University of Barcelona has participated in the design of the first light-activated drug -the JF-NP-26, for the treatment of pain, according to a research with animal models published in the journal eLife.

11 Apr 2017

Metabolite produced by intestinal bacteria protects against type 2 diabetes, study shows

A high concentration of indolepropionic acid in the serum protects against type 2 diabetes, shows a new study from the University of Eastern Finland. Indolepropionic acid is a metabolite produced by intestinal bacteria, and its production is boosted by a fibre-rich diet.

11 Apr 2017

Combination of NSAIDs and gastric protection can lead to inflammation in small intestine

Patients with inflammatory diseases are often prescribed non-steroidal anti-inflammatory drugs. They are also often recommended to use a proton pump inhibitor to protect their stomach.

11 Apr 2017

Identifying serious bowel conditions in under-50s

The fundamental problem is that the symptoms are very similar, or at least some are. Taking your example of IBS – this is characterised by abdominal pain, plus sometimes diarrhoea or constipation. Yet these are key symptoms of abdominal cancer!

11 Apr 2017

AAOS issues new guidelines for treatment of hip osteoarthritis

The American Academy of Orthopaedic Surgeons recently released a new clinical practice guideline on the treatment of osteoarthritis of the hip that strongly recommends the use of pre-surgical treatments to ease pain and improve mobility, including corticosteroid injections, physical therapy and non-narcotic medications.

11 Apr 2017

Scientists discover new role for autophagosomes in neurodegenerative diseases

Autophagosomes are at the center of attention, at least since the Nobel Prize for Medicine was awarded for research on autophagy in 2016. The much talked about autophagosomes are small membrane vesicles in charge of waste disposal to promote recycling of its components.

11 Apr 2017

Careful counselling from clinicians may help alleviate anxiety in wAMD patients

Highly effective current treatments for vision loss need to be allied with careful counselling to ensure patients maintain good psychological health as well as good vision, new research recommends.

From The University of Manchester 11 Apr 2017

Medical Condition News

Study may provide insight into how R-LA promotes death of hepatoma cells

Point/Counterpoint: Experts debate how to control exploding opioid epidemic

Disability simulations do more harm than good, study reveals

Researchers explore patient adherence, tolerability to class of Alzheimer's drugs

PID1 gene increases killing effect of chemotherapy drugs on brain tumor cells

Researchers use genetic manipulation to regenerate auditory hair cells in adult mice

Scientists discover novel therapeutic target for retinal neovascularization

FDA grants approval for first drug to treat adults with tardive dyskinesia

New nanowire technology may serve as platform to screen drugs for neurological diseases

Feinstein Institute research may lead to new treatment option for low-grade gliomas

Duke researchers link specific differences in brain structure to multiple forms of mental disorder

Western-led research uncovers underlying molecular mechanism that controls acoustic habituation

JAX professor receives grant from National Eye Institute to study diseases of retinal pigment epithelium

Researchers design first light-activated drug for treatment of pain

Metabolite produced by intestinal bacteria protects against type 2 diabetes, study shows

Combination of NSAIDs and gastric protection can lead to inflammation in small intestine

Identifying serious bowel conditions in under-50s

AAOS issues new guidelines for treatment of hip osteoarthritis

Scientists discover new role for autophagosomes in neurodegenerative diseases

Careful counselling from clinicians may help alleviate anxiety in wAMD patients

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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