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Researchers describe generation of plasma cell-specific antibody from immunized lampreys

Antibody-secreting plasma cells arise from B cell precursors and are essential for adaptive immune responses against invading pathogens. Plasma cell dysfunction is associated with autoimmune and neoplastic disorders, including multiple myeloma.

21 Mar 2016

Researchers elucidate mechanisms underlying impaired ciliogenesis in PKD

In an article published online ahead of print on Feb. 19, 2015 in the Journal of Biological Chemistry, investigators at the Medical University of South Carolina and the Ralph H. Johnson VA Medical Center report findings from in vitro and in vivo studies that elucidate the mechanisms underlying the impaired ciliogenesis and abnormal kidney development characteristic of polycystic kidney disease (PKD).

21 Mar 2016

Novel compound shows promise as potential treatment for acute myeloid leukemia

A novel compound has shown promise in preclinical studies as a treatment for acute myeloid leukemia, more than doubling median days of survival even in a drug-resistant form of the disease.

21 Mar 2016

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Acute myeloid leukemia (AML) is a cancer of myeloid stem cells that develops in both adult and pediatric populations. Mutations that cause hyperactivation of the FMS-like tyrosine kinase 3 (FLT3) are commonly found in AML, and several clinical trials are testing FLT3 inhibitors.

21 Mar 2016

Study suggests need for better strategy to reduce fatalities after non-surgical treatment for blocked arteries

Despite the successful adoption of modern techniques, new research from the Universities of Keele and Manchester suggests more can be done to reduce fatalities following a non-surgical treatment for blocked arteries.

21 Mar 2016

Trimeprazine improves β cell function, slows progression of diabetes

β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in type 2 diabetes, pancreatic β cells may have deficiencies in secreting insulin or insulin-responding tissues can become insulin resistant.

21 Mar 2016

Public health benefits of using more recycled water

Expanding the use of recycled water would reduce water and energy use, cut greenhouse gas emissions and benefit public health in California -- which is in the midst of a severe drought -- and around the world.

21 Mar 2016

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib (trade name: Cotellic) has been approved since November 2015 in combination with vemurafenib for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation.

21 Mar 2016

APS strongly recommends National Pain Strategy to better educate physicians about pain

The American Pain Society today endorsed the federal government's National Pain Strategy for its recommendations to better educate primary care physicians about pain and pain treatments, reduce stigma by increasing public awareness about pain and its overall impact on society, and expanding access to personalized multimodal and multidisciplinary pain care.

21 Mar 2016

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

A common theme in medicine is that detecting a disease early on can lead to more effective treatments. This relies partly on luck that the patient gets screened at the right time, but more important is that the testing techniques are sensitive enough to register the minuscule hints that diseases leave in the blood stream.

21 Mar 2016

Six1 gene may have more substantial role in human kidney development

The best laid plans of mice and men are a bit different -- at least when it comes to kidney development. Compared to a mouse, a human has nearly 100 times more nephrons, the functional units of the kidneys. Humans may owe these abundant nephrons to a gene called SIX1, according to a new paper published in the journal Development.

21 Mar 2016

PERK inhibition can be a promising therapeutic strategy for neurodegenerative diseases

A major challenge in the field of neurodegeneration is the unclear understanding of neuronal dysfunction. Elucidation of these patho-mechanisms could result in the identification of novel therapeutic targets. In this article, Bell et al. present an exhaustive literature review highlighting the endoplasmic reticulum (ER) kinase PERK as a crucial contributor to systemic and neurodegenerative disorders.

20 Mar 2016

New type of nerve cells appears to control feeding behaviors in mice

While researching the brain's learning and memory system, scientists at Johns Hopkins say they stumbled upon a new type of nerve cell that seems to control feeding behaviors in mice. The finding, they report, adds significant detail to the way brains tell animals when to stop eating and, if confirmed in humans, could lead to new tools for fighting obesity. Details of the study will be published by the journal Science on March 18.

20 Mar 2016

Behavioral scientist shares insights about FDA's proposed rule on banning tanning bed use among minors

In late December 2015, the U.S. Food and Drug Administration proposed a number of new restrictions related to the use of tanning beds, including banning their use among individuals younger than 18 years.

19 Mar 2016

Innovative treatment may help prevent brain swelling, death in stroke patients

New research has provided more evidence that an innovative treatment strategy may help prevent brain swelling and death in stroke patients. J. Marc Simard, professor of neurosurgery at the University of Maryland School of Medicine, along with colleagues at Yale University and Massachusetts General Hospital, found that Cirara, an investigational drug, powerfully reduced brain swelling and death in patients who had suffered a type of large stroke called malignant infarction, which normally carries a high mortality rate.

19 Mar 2016

Patients with schizophrenia demonstrate specific leftward asymmetry for globus pallidus volume

A Japanese research group found that patients with schizophrenia demonstrated a specific leftward volumetric asymmetry for the globus pallidus, one of the basal ganglia of the brain. The basal ganglia are involved in motivation and volition, the impairment of which may result in difficulties in social life. This finding is expected to help elucidate the underlying pathological mechanisms of schizophrenia. Moreover, it will be a step toward the development of therapeutic strategies for schizophrenia.

19 Mar 2016

Gay, bisexual, lesbian Canadians experience high levels of mood and anxiety disorders

Gay, lesbian and bisexual Canadians experience more mood and anxiety disorders than other Canadians, and they are more likely to turn to heavy drinking.

19 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Cancer cells have the ability to grow in an acidic tumor environment that is detrimental to other cells, including immune cells. In a Cancer Research cover article published this week, Moffitt Cancer Center reported that neutralizing the acidic tumor environment increases the efficacy of several immune-targeting cancer therapies.

19 Mar 2016

World sleep day tackles poor sleep due to nocturia

Today is World Sleep Day, an annual global event that aims to improve sleep health worldwide. World Sleep Day is organized by the World Association of Sleep Medicine (WASM) to spread awareness of important sleep-related issues and the burden insomnia places on society through a series of special events. This year it is focussing on sleep loss resulting from the need to urinate during the night.

18 Mar 2016

Medical Condition News

Researchers describe generation of plasma cell-specific antibody from immunized lampreys

Researchers elucidate mechanisms underlying impaired ciliogenesis in PKD

Novel compound shows promise as potential treatment for acute myeloid leukemia

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Study suggests need for better strategy to reduce fatalities after non-surgical treatment for blocked arteries

Trimeprazine improves β cell function, slows progression of diabetes

Public health benefits of using more recycled water

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

APS strongly recommends National Pain Strategy to better educate physicians about pain

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

Six1 gene may have more substantial role in human kidney development

PERK inhibition can be a promising therapeutic strategy for neurodegenerative diseases

New type of nerve cells appears to control feeding behaviors in mice

Behavioral scientist shares insights about FDA's proposed rule on banning tanning bed use among minors

Innovative treatment may help prevent brain swelling, death in stroke patients

Patients with schizophrenia demonstrate specific leftward asymmetry for globus pallidus volume

Gay, bisexual, lesbian Canadians experience high levels of mood and anxiety disorders

Manipulation of NAD could lead to potential therapy for acute kidney injury

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

World sleep day tackles poor sleep due to nocturia

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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