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People with intermittent explosive disorder have smaller 'emotional brains'

Neuroimaging studies suggest that frontolimbic regions of the brain, structures that regulate emotions, play an important role in the biology of aggressive behavior.

13 Jan 2016

First trials of smart gas sensing pills offer new clues for development of gut disorder treatments

Researchers have conducted the first ever trials of smart pills that can measure intestinal gases inside the body, with surprising results revealing some unexpected ways that fibre affects the gut.

13 Jan 2016

Researchers reveal totally new biological mechanism that underlies cancer

In a landmark study, researchers from the Broad Institute and Massachusetts General Hospital reveal a completely new biological mechanism that underlies cancer. By studying brain tumors that carry mutations in the isocitrate dehydrogenase (IDH) genes, the team uncovered some unusual changes in the instructions for how the genome folds up on itself.

13 Jan 2016

New discovery may help researchers tackle mitochondrial diseases and age-related diseases

Buck Institute faculty Judith Campisi, PhD, says age researchers need to stop thinking of cellular senescence, now accepted as an important driver of aging, as a single phenotype that stems from genotoxic stress. Research from her lab reveals that cellular senescence, a process whereby cells permanently lose the ability to divide, is also induced by signaling from dysfunctional mitochondria - and that the arrested cells secrete a distinctly different "stew" of biologically active factors in a process unrelated to the damaging free radicals that are created in mitochondria as part of oxygen metabolism.

13 Jan 2016

Long-term use of opioids increases risk of new-onset depression

Opioids may cause short-term improvement in mood, but long-term use imposes risk of new-onset depression, a Saint Louis University study shows.

13 Jan 2016

Using statins before and after heart surgery can help reduce cardiac complications, mortality risks

Using statins before and after coronary artery bypass grafting (CABG) surgery can help reduce cardiac complications, such as atrial fibrillation, following surgery and also can reduce the risk of death during and after surgery, according to a review article posted online today by The Annals of Thoracic Surgery.

13 Jan 2016

First patient enrolled in ThromboGenics' Phase II CIRCLE study of ocriplasmin in NPDR patients

ThromboGenics NV, an integrated biopharmaceutical company focused on developing and commercializing innovative treatments for diabetic eye disease, today announces that the first patient has been enrolled in its Phase II CIRCLE study evaluating the efficacy and safety of multiple doses of ocriplasmin in inducing total posterior vitreous detachment (PVD) in patients with non-proliferative diabetic retinopathy (NPDR).

13 Jan 2016

New clinical study reveals previously unknown risk factors linked to keratoconus

A large new study reveals previously unknown risk factors associated with an eye condition that causes serious progressive nearsightedness at a relatively young age.

13 Jan 2016

New UTMB study reveals link between traumatic brain injury and Alzheimer's disease

A new study from The University of Texas Medical Branch at Galveston fills an important gap in understanding the link between traumatic brain injury and neurodegenerative disorders such as Alzheimer's disease.

13 Jan 2016

Pulmonary neuroendocrine cells act like sensor to orchestrate immune response

An uncommon and little-studied type of cell in the lungs has been found to act like a sensor, linking the pulmonary and central nervous systems to regulate immune response in reaction to environmental cues.

13 Jan 2016

Researchers reveal secondary structure of Lewy bodies in the brain of Parkinson's disease patients

Lewy bodies had been considered to be a key element of pathogenesis for Parkinson's disease. Although structural analysis for Lewy bodies with an electron microscope had been performed, it had no secondary structural information of proteins, which is important for the development of drugs.

13 Jan 2016

Inflammation associated with elevated glutamate in the brain could guide depression treatments

Psychiatrists investigating depression have been energized in recent years by reports of rapid, successful treatment with drugs that interfere with the brain chemical glutamate, such as the anesthetic ketamine.

13 Jan 2016

CGP3466B compound may effectively treat depression

The compound CGP3466B, already proven nontoxic for people, may effectively and rapidly treat depression, according to results of a study in mice.

13 Jan 2016

Treatment for oesophageal cancer, Barrett’s oesophagus varies significantly across England

New figures released today show that the treatment received by patients for oesophageal cancer, and its precursor condition Barrett’s oesophagus, varies significantly across England.

13 Jan 2016

Switching to smaller plates could help curb obesity

There are small easy steps that we can take to tackle the burgeoning problem of obesity. One of those solutions is surprisingly simple: use smaller plates.

13 Jan 2016

Cornell researchers identify potent cancer-killing proteins that can kill tumors in bloodstream

Cornell researchers have discovered potent cancer-killing proteins that can travel by white blood cells to kill tumors in the bloodstream of mice with metastatic prostate cancer. The breakthrough study will be published Feb. 10 as the cover article in the Journal of Controlled Release.

13 Jan 2016

CPMC study discovers six genes that affect sleep duration

The Coriell Personalized Medicine Collaborative, a research initiative exploring the utility of genetic information in the clinical setting, has published a study and identified six noteworthy genes that affect human sleep duration.

13 Jan 2016

Sedentary behavior associated with poor cardiovascular health, diabetes in people with severe obesity

Sedentary behavior is associated with poor cardiovascular health and diabetes in adults with severe obesity, independent of how much exercise they perform, a University of Pittsburgh Graduate School of Public Health-led study showed for the first time.

13 Jan 2016

New gene-filtering tool aims to predict disease-causing mutations

Despite their bad reputations, the vast majority of mutations are not harmful. Even in very rare genetic disorders, only one or two genetic variations — out of tens of thousands — is actually the cause of disease. Distinguishing between harmful and harmless mutations has long been a challenge.

13 Jan 2016

New mechanism of differentiation may offer novel therapeutic approaches to blood malignancies, solid tumors

In humans the differentiation of stem cells into hundreds of specialized cell types is vital. Differentiation drives development from fertilized egg to a newborn, and it underlies the continuous replacement of the 5 billion cells that die every hour in an adult. On the downside, mutations in differentiation pathways of different cell types can be drivers of cancers.

13 Jan 2016

Medical Condition News

People with intermittent explosive disorder have smaller 'emotional brains'

First trials of smart gas sensing pills offer new clues for development of gut disorder treatments

Researchers reveal totally new biological mechanism that underlies cancer

New discovery may help researchers tackle mitochondrial diseases and age-related diseases

Long-term use of opioids increases risk of new-onset depression

Using statins before and after heart surgery can help reduce cardiac complications, mortality risks

First patient enrolled in ThromboGenics' Phase II CIRCLE study of ocriplasmin in NPDR patients

New clinical study reveals previously unknown risk factors linked to keratoconus

New UTMB study reveals link between traumatic brain injury and Alzheimer's disease

Pulmonary neuroendocrine cells act like sensor to orchestrate immune response

Researchers reveal secondary structure of Lewy bodies in the brain of Parkinson's disease patients

Inflammation associated with elevated glutamate in the brain could guide depression treatments

CGP3466B compound may effectively treat depression

Treatment for oesophageal cancer, Barrett’s oesophagus varies significantly across England

Switching to smaller plates could help curb obesity

Cornell researchers identify potent cancer-killing proteins that can kill tumors in bloodstream

CPMC study discovers six genes that affect sleep duration

Sedentary behavior associated with poor cardiovascular health, diabetes in people with severe obesity

New gene-filtering tool aims to predict disease-causing mutations

New mechanism of differentiation may offer novel therapeutic approaches to blood malignancies, solid tumors

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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