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Insulin-producing cells' mitochondria may represent useful therapeutic target in type 2 diabetes

Factors in the blood from calorie-restricted rats can modify energy-producing mitochondria within the insulin-producing cells that regulate blood sugar levels, new research shows. This has a positive impact on glucose-stimulated insulin secretion and protects cells from fatty acid and glucose toxicity.

7 Jan 2016

Statins could be effective against metastatic small cell lung cancer

In a recent study, researchers at Cancer Treatment Centers of America at Western Regional Medical Center (Western), in collaboration with international colleagues, found that statins could be an effective therapeutic against metastatic small cell lung cancer (SCLC).

7 Jan 2016

NIH-funded clinical study examines new method for sparing healthy lung tissue during radiotherapy

A newly NIH funded clinical trial (NCT02528942) by University of Colorado Cancer Center investigators and collaborators at Beaumont Health in Michigan and the University of Texas Medical Branch is evaluating a new method for pinpointing and sparing healthy lung tissue during lung cancer radiotherapy.

7 Jan 2016

Eliminating the 'bad seeds' of liver cancer

Researchers have found the 'bad seeds' of liver cancer and believe they could one day reprogram them to remain responsive to cancer treatment, a new study has found.

7 Jan 2016

Physician-researchers find link between 'dry eye' and chronic pain syndromes

Physician-researchers with Bascom Palmer Eye Institute, part of UHealth--the University of Miami Health System, have found a link between "dry eye" and chronic pain syndromes -- a finding that suggests that a new paradigm is needed for diagnosis and treatment to improve patient outcomes.

7 Jan 2016

UF researchers reveal link between chronic stress and fat metabolism

In cell and mouse model experiments, University of Florida Health researchers have discovered that chronic stress stimulates production of betatrophin, a protein that then goes on to inhibit an enzyme involved in fat metabolism.

7 Jan 2016

Rani Therapeutics, MedImmune collaborate to evaluate novel oral drug delivery platform

Rani Therapeutics announced today that it has entered into a collaboration with MedImmune, the global biologics research and development arm of AstraZeneca, to evaluate Rani's novel oral drug delivery platform. The companies have agreed to conduct feasibility studies over the next two years, in which Rani will test select biologic molecules in the area of metabolic disease to evaluate the oral delivery of these molecules.

6 Jan 2016

DURECT reports successful completion of DUR-928 Phase 1 study for acute use indications

DURECT Corporation today announced the successful completion of a Phase 1 clinical trial with an injectable formulation of DUR-928 intended for acute use indications. DUR-928 is an endogenous, small-molecule, new chemical entity (NCE), which may have broad applicability in metabolic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), and in acute organ injuries such as acute kidney injury (AKI).

6 Jan 2016

Vtesse receives FDA's Breakthrough Therapy designation for VTS-270

Vtesse, Inc. announced today that the U.S. Food and Drug Administration has granted its drug candidate, VTS-270 for treatment of Niemann-Pick Type C1 Disease (NPC), Breakthrough Therapy designation status. Both the FDA and the European Medicines Agency (EMA) had previously granted Orphan Drug status to VTS-270, which is currently in a pivotal Phase 2b/3 clinical trial.

6 Jan 2016

Toxins in staphylococcus bacteria can help cancer cells gain control over healthy cells

Our skin is covered in millions of bacteria and most of them help keep us healthy. However, for patients with lymphoma, it may be a rather different story, as new research from the University of Copenhagen shows that toxins in the staphylococcus bacteria help cancer cells gain control over healthy cells.

6 Jan 2016

Mayo Clinic Diet offers weight-loss and lifestyle program based on research, clinical experience

Turning the calendar to a new year often finds people working on their commitment to a healthy lifestyle. When it comes to losing weight, experts advise taking a longer view, beyond a New Year's resolution.

6 Jan 2016

Vanderbilt-led study questions about reporting genetic results to patients

A genetic test that suggests a patient may be at increased risk for potentially fatal heart rhythms is very often not as ominous as it sounds.

6 Jan 2016

Typical premium-based financial incentives fail to promote weight loss among obese employees

Employers around the nation are increasingly searching for ways to help their employees make healthy lifestyle choices including encouraging obese employees to lose weight, often by offering financial incentives in the form of reduced health insurance premiums to help encourage success.

6 Jan 2016

Obese young people can still avoid diabetes risk if they lose weight before middle age

Obese young people can still turn their chances of developing life threatening illness around if they change before middle age, says new research.

6 Jan 2016

New TAU study offers tangible hope of curing Mantle Cell Lymphoma

With a median survival rate of just five to seven years, Mantle Cell Lymphoma (MCL) is considered the most aggressive known blood cancer -- and available therapies are scarce. Three thousand Americans are diagnosed with MCL every year, and despite progress in personalized therapies to treat metastases elsewhere in the body, systemic therapeutic drug delivery to cancerous blood cells continues to challenge the world of cancer research.

6 Jan 2016

UNC researchers uncover new potential strategy to kill cancerous cells in the brain

Rapidly dividing cells rely on an enzyme called Dicer to help them repair the DNA damage that occurs as they make mistakes in copying their genetic material over and over for new cells. UNC Lineberger Comprehensive Cancer Center researchers have built on the discovery of Dicer's role in fixing DNA damage to uncover a new potential strategy to kill rapidly dividing, cancerous cells in the brain.

6 Jan 2016

Naturally occurring changes in brain wiring can help patients avert onset of bipolar disorder

Naturally occurring changes in brain wiring can help patients at high genetic risk of developing bipolar disorder avert the onset of the illness, according to a new study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Translational Psychiatry.

6 Jan 2016

Researchers identify mechanism that allows cancer cells to grow rapidly when blood sugar levels rise

Researchers have identified a mechanism that allows cancer cells to respond and grow rapidly when levels of sugar in the blood rise. This may help to explain why people who develop conditions in which they have chronically high sugar levels in their blood, such as obesity, also have an increased risk of developing certain types of cancer.

6 Jan 2016

$Major bone fracture may increase risk of widespread chronic body pain in later life$

Major bone fracture may increase risk of widespread chronic body pain in later life

Breaking a major bone may increase risk of widespread chronic body pain in later life, a new study has found.

6 Jan 2016

New study finds familial risk and heritability of cancer among twins

A large new study of twins has found that having a twin sibling diagnosed with cancer poses an excess risk for the other twin to develop any form of cancer. Among the 23 different types of cancer studied, an excess familial risk was seen for almost all of the cancers, including common cancers such as breast and prostate cancer, but also more rare cancers such as testicular cancer, head and neck cancer, melanoma, ovarian and stomach cancer.

6 Jan 2016

Medical Condition News

Insulin-producing cells' mitochondria may represent useful therapeutic target in type 2 diabetes

Statins could be effective against metastatic small cell lung cancer

NIH-funded clinical study examines new method for sparing healthy lung tissue during radiotherapy

Eliminating the 'bad seeds' of liver cancer

Physician-researchers find link between 'dry eye' and chronic pain syndromes

UF researchers reveal link between chronic stress and fat metabolism

Rani Therapeutics, MedImmune collaborate to evaluate novel oral drug delivery platform

DURECT reports successful completion of DUR-928 Phase 1 study for acute use indications

Vtesse receives FDA's Breakthrough Therapy designation for VTS-270

Toxins in staphylococcus bacteria can help cancer cells gain control over healthy cells

Mayo Clinic Diet offers weight-loss and lifestyle program based on research, clinical experience

Vanderbilt-led study questions about reporting genetic results to patients

Typical premium-based financial incentives fail to promote weight loss among obese employees

Obese young people can still avoid diabetes risk if they lose weight before middle age

New TAU study offers tangible hope of curing Mantle Cell Lymphoma

UNC researchers uncover new potential strategy to kill cancerous cells in the brain

Naturally occurring changes in brain wiring can help patients avert onset of bipolar disorder

Researchers identify mechanism that allows cancer cells to grow rapidly when blood sugar levels rise

Major bone fracture may increase risk of widespread chronic body pain in later life

New study finds familial risk and heritability of cancer among twins

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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