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EMA extends approval of Vectibix plus FOLFIRI as first-line treatment for wild-type RAS mCRC

Amgen today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency adopted a positive opinion to extend the marketing authorization for Vectibix (panitumumab) to include combination with FOLFIRI (an irinotecan-based chemotherapy) as first-line treatment in adult patients with wild-type RAS metastatic colorectal cancer (mCRC).

3 Mar 2015

Sall4 protein helps fix DNA damage

A protein that helps embryonic stem cells (ESCs) retain their identity also promotes DNA repair, according to a study in The Journal of Cell Biology. The findings raise the possibility that the protein, Sall4, performs a similar role in cancer cells, helping them fix DNA damage to survive chemotherapy.

3 Mar 2015

Toning down TREM2 receptor's activity may help prevent neurodegeneration in AD patients

Tackling brain inflammation ameliorates Alzheimer's disease (AD), according to a study published in The Journal of Experimental Medicine.

3 Mar 2015

New genetic discovery may lead to effective treatments for Huntington's disease

A new genetic discovery in the field of Huntington's disease (HD) could mean a more effective way in determining severity of this neurological disease when using specific treatments. This study may provide insight for treatments that would be effective in slowing down or postponing the death of neurons for people who carry the HD gene mutation, but who do not yet show symptoms of the disease.

2 Mar 2015

People with diabetes more prone to depression, anxiety

People with diabetes are more prone to anxiety and depression than those with other chronic diseases that require similar levels of management. The reasons for this aren't well understood, but Joslin Diabetes Center researchers have discovered one potential explanation.

2 Mar 2015

Celimmune licenses anti-IL-15 monoclonal antibody from Amgen

Celimmune LLC, a clinical development-stage immunotherapy company focused on treating and preventing autoimmune diseases, announced today that it has licensed a Phase 2-stage, anti-IL-15 monoclonal antibody (AMG 714) from Amgen.

2 Mar 2015

Study shows importance of disclosing physician conflicts of interest in MS ISCTs to potential participants

If you're one of the nearly half a million Americans living with multiple sclerosis (MS) - a slowly disabling disease of the central nervous system - you are likely dependent on disease-modifying drugs to prevent symptoms such as vision problems, balance issues and weakness. Often, these treatments have been developed through pharmaceutical industry-sponsored clinical trials (ISCT) in collaboration with academic or private practice physicians who care for MS patients.

2 Mar 2015

Cancer Care Ontario raises awareness about colorectal cancer

March is Colorectal Cancer Awareness Month and Cancer Care Ontario (CCO) is on a mission to raise awareness about an organ that doesn't get the attention it deserves.

2 Mar 2015

Taiho announces submission of TAS-102 MAA to EMA for treatment of mCRC

Taiho Pharma Europe Ltd., a subsidiary of Japan based Taiho Pharmaceutical Co., Ltd., announced that it has submitted a Marketing Authorisation Application to the European Medicines Agency for TAS-102 (nonproprietary names: trifluridine and tipiracil hydrochloride), an oral combination anticancer drug intended for use in the treatment of refractory metastatic colorectal cancer (mCRC).

2 Mar 2015

Transition completes enrolment of patients in ELND005 Phase 2 study for treatment of AD patients

Transition Therapeutics Inc. announced that its wholly owned subsidiary, Transition Therapeutics Ireland Limited completed enrolment of the Phase 2 clinical study evaluating neuropsychiatric drug candidate ELND005 as a treatment for agitation and aggression in patients with mild, moderate and severe Alzheimer's disease ("AD").

2 Mar 2015

Bielefeld University chemists develop copper molecule that could help prevent spread of cancer

Chemists at Bielefeld University have developed a molecule containing copper that binds specifically with DNA and prevents the spread of cancer. First results show that it kills the cancer cells more quickly than cisplatin - a widely used anti-cancer drug that is frequently administered in chemotherapy.

2 Mar 2015

U-M researchers reveal key role of two enzymes that help the body to remove cholesterol, other lipids

With the aid of X-ray crystallography, researchers at the University of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body's ability to metabolize excess lipids, including cholesterol.

2 Mar 2015

Minihepcidin reverses iron overload of hemochromatosis, stops susceptibility to infections

Hemochromatosis (HH) is the most common genetic disorder in the western world, and yet is barely known. Only in the US 1 in 9 people carry the mutation (although not necessarily the disease).

2 Mar 2015

Study shows heart valve repair can benefit patients with mitral regurgitation

Patients with severe mitral regurgitation (MR) often suffer from psycho-emotional symptoms, such as depression and anxiety, but after undergoing mitral valve repair surgery patients experience a marked improvement in emotional and physical wellbeing, according to an article in the March 2015 issue of The Annals of Thoracic Surgery.

2 Mar 2015

Study details a new pathway for tumor formation

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine (SVM) have identified the biological mechanism that may give some cancer cells the ability to form tumors in dogs.

2 Mar 2015

Blood tests in heart surgery patients can lead to anemia, blood transfusions

Laboratory testing among patients undergoing cardiac surgery can lead to excessive bloodletting, which can increase the risk of developing hospital-acquired anemia and the need for blood transfusion, according to an article in the March 2015 issue of The Annals of Thoracic Surgery.

2 Mar 2015

New algorithm can gauge long-term death risk based on treadmill exercise performance

Analyzing data from 58,000 heart stress tests, Johns Hopkins cardiologists report they have developed a formula that estimates one's risk of dying over a decade based on a person's ability to exercise on a treadmill at an increasing speed and incline.

2 Mar 2015

Study shows only 44% of black males prefer to be investigated for prostate cancer

The incidence of prostate cancer among men of Afro-Caribbean origin is higher than in white men, they are more likely to be diagnosed as emergencies and their mortality rates are higher.

2 Mar 2015

Scientists discover amyloid accumulation in young human brains

Amyloid -- an abnormal protein whose accumulation in the brain is a hallmark of Alzheimer's disease -- starts accumulating inside neurons of people as young as 20, a much younger age than scientists ever imagined, reports a surprising new Northwestern Medicine study.

2 Mar 2015

Mesothelioma Victims Center now offers guidance for former power plant workers with mesothelioma

The Mesothelioma Victims Center is now making the best possible compensation a reality for former power plant workers who have been diagnosed with mesothelioma, because these types of individuals could qualify for multi-million dollar mesothelioma settlements.

28 Feb 2015

Medical Condition News

EMA extends approval of Vectibix plus FOLFIRI as first-line treatment for wild-type RAS mCRC

Sall4 protein helps fix DNA damage

Toning down TREM2 receptor's activity may help prevent neurodegeneration in AD patients

New genetic discovery may lead to effective treatments for Huntington's disease

People with diabetes more prone to depression, anxiety

Celimmune licenses anti-IL-15 monoclonal antibody from Amgen

Study shows importance of disclosing physician conflicts of interest in MS ISCTs to potential participants

Cancer Care Ontario raises awareness about colorectal cancer

Taiho announces submission of TAS-102 MAA to EMA for treatment of mCRC

Transition completes enrolment of patients in ELND005 Phase 2 study for treatment of AD patients

Bielefeld University chemists develop copper molecule that could help prevent spread of cancer

U-M researchers reveal key role of two enzymes that help the body to remove cholesterol, other lipids

Minihepcidin reverses iron overload of hemochromatosis, stops susceptibility to infections

Study shows heart valve repair can benefit patients with mitral regurgitation

Study details a new pathway for tumor formation

Blood tests in heart surgery patients can lead to anemia, blood transfusions

New algorithm can gauge long-term death risk based on treadmill exercise performance

Study shows only 44% of black males prefer to be investigated for prostate cancer

Scientists discover amyloid accumulation in young human brains

Mesothelioma Victims Center now offers guidance for former power plant workers with mesothelioma

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

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