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Intriguing small molecule directs activity of key ‘clock proteins’

In research published in Nature Communications, Thomas Burris, Ph.D., chair of pharmacological and physiological science at Saint Louis University, reports intriguing findings about a small molecule that directs the activity of key "clock proteins," offering the potential to manage circadian rhythm and treat problems that are associated with its dysfunction, like sleep and anxiety disorders.

24 Dec 2014

ADA lowers BMI cut point for screening Asian Americans for type 2 diabetes

The American Diabetes Association announced today that they are lowering the Body Mass Index (BMI) cut point for which they recommend screening Asian Americans for type 2 diabetes. These new guidelines derives from a position statement that will be published in the January issue of Diabetes Care, showing that many Asian Americans develop type 2 diabetes at lower BMI levels than the population at large.

24 Dec 2014

Transcranial direct current stimulation can help modify attention to threat

Transcranial direct current stimulation (tDCS) is a painless treatment strategy that uses weak electrical currents to deliver targeted stimulation to the brain via electrodes placed on the scalp. tDCS has shown promise in treating mood, anxiety, cognition, and some symptoms of Parkinson's disease.

24 Dec 2014

Researchers identify mutations that destabilize DNA structure that turns a gene off

Researchers at the University of Louisville's James Graham Brown Cancer Center have identified for the first time mutations that destabilize a DNA structure that turns a gene off. These mutations occur at four specific sites in what is known as the "hTERT promoter" in more than 75 percent of glioblastomas and melanomas.

24 Dec 2014

Cancer could be broken down by its evolving defense mechanism

Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) has evoked Star Trek's Borg in her fight against the disease.

24 Dec 2014

Whole-genome sequencing can identify patients' risk for hereditary cancer

UT Southwestern Medical Center cancer researchers have demonstrated that whole-genome sequencing can be used to identify patients' risk for hereditary cancer, which can potentially lead to improvements in cancer prevention, diagnosis, and care.

24 Dec 2014

Innovative software predicts sudden cardiac death in patients at risk of arrhythmia

At Galway Hospital, in Ireland, a device is currently used to "predict" cardiac events in people at risk of sudden cardiac death.

24 Dec 2014

Unauthorized weight loss product seized from two retail locations in southwest of Calgary

The unauthorized product "Hydro-Lean" was seized from two Calgary stores because the label indicates it contains a combination of ingredients that can cause serious health risks (ephedrine and caffeine).

23 Dec 2014

Next generation sequencing in malignant pleural mesothelioma tumors reveals complex mutational setting

Next generation sequencing in malignant pleural mesothelioma (MPM) tumors shows a complex mutational setting with a high number of genetic alterations in genes involved in DNA repair, cell survival and cell proliferation pathways. Increased accumulation of mutations correlates with early progression of the tumor and decreased survival.

23 Dec 2014

PTC begins rolling NDA submission for Translarna to treat nmDMD

PTC Therapeutics, Inc. today announced that it has commenced a rolling submission of a New Drug Application to the United States Food and Drug Administration for Translarna™ for the treatment of nonsense mutation Duchenne muscular dystrophy (nmDMD).

23 Dec 2014

AMIC files de novo submission with FDA for Y-90 RadioGel device, seeks Class II reclassification

Advanced Medical Isotope Corporation, a late stage development company engaged primarily in the development of brachytherapy devices and medical isotopes for diagnostic and therapeutic applications, today announced that it has filed a de novo submission with the Food and Drug Administration for marketing clearance for its patented Y-90 RadioGel(TM) device pursuant to Section 513(f)(2) of the U.S. Food, Drug and Cosmetic Act.

23 Dec 2014

Mirati begins dosage in MGCD265 Phase 1b clinical trial for NSCLC

Mirati Therapeutics, Inc. today announced that the first patient with Non-Small Cell Lung Cancer (NSCLC) has been dosed in a Phase 1b clinical trial of MGCD265 in selected patients exhibiting genetic alterations of MET or Axl.

23 Dec 2014

EMA validates Synageva's sebelipase alfa MAA for LAL Deficiency

Synageva BioPharma Corp., a biopharmaceutical company developing therapeutic products for rare disorders, today announced validation by the European Medicines Agency of the Marketing Authorization Application for sebelipase alfa for LAL Deficiency.

23 Dec 2014

Radiation/chemotherapy increases risk of leukemia in early-stage breast cancer patients

The risk of developing leukemia after radiation therapy or chemotherapy for early stage breast cancer remains very small, but it is twice as high as previously reported, according to results of a new study led by researchers at the Johns Hopkins Kimmel Cancer Center.

23 Dec 2014

Pivotal trial of Elios melanoma vaccine to be conducted at top U.S. cancer hospitals

Elios Therapeutics, LLC recently received FDA approval of its Investigational New Drug (IND) application and its randomized phase IIb trial planned to enroll 120 stage III and IV (resected) melanoma patients to assess the ability of a personalized vaccine to prevent recurrence.

23 Dec 2014

Endogenous retroviruses play critical role in body's immune defense against bacterial, viral pathogens

Retroviruses are best known for causing contagious scourges such as AIDS, or more sporadically, cancer.

23 Dec 2014

Treatment for stroke: Intra-arterial treatment more effective than standard medical care for clot removal

Study results released today in The New England Journal of Medicine gave the world of stroke care more evidence that physicians are winning the battle against this debilitating disease, which affects as many as one in six people.

23 Dec 2014

Study reveals why older people are at higher risk for developing cancer

Why are older people at higher risk for developing cancer? Prevailing opinion holds that, over time, your body's cells accumulate DNA damage and that eventually this damage catches up with the body in a way that causes cancer.

23 Dec 2014

Research shows modern humans have less bone density than earlier human ancestors

New research shows that modern human skeletons evolved into their lightly built form only relatively recently — after the start of the Holocene about 12,000 years ago, and even more recently in some human populations.

23 Dec 2014

First two patients enrolled in AGA’s GERD Registry successfully undergo treatment

The American Gastroenterological Association (AGA) Center for GI Innovation and Technology is pleased to announce that the first two enrollees in the STAR Registry — which seeks to compare laparoscopic surgery to an incisionless procedure to treat gastroesophageal reflux disease (GERD) — have successfully undergone treatment.

23 Dec 2014

Medical Condition News

Intriguing small molecule directs activity of key ‘clock proteins’

ADA lowers BMI cut point for screening Asian Americans for type 2 diabetes

Transcranial direct current stimulation can help modify attention to threat

Researchers identify mutations that destabilize DNA structure that turns a gene off

Cancer could be broken down by its evolving defense mechanism

Whole-genome sequencing can identify patients' risk for hereditary cancer

Innovative software predicts sudden cardiac death in patients at risk of arrhythmia

Unauthorized weight loss product seized from two retail locations in southwest of Calgary

Next generation sequencing in malignant pleural mesothelioma tumors reveals complex mutational setting

PTC begins rolling NDA submission for Translarna to treat nmDMD

AMIC files de novo submission with FDA for Y-90 RadioGel device, seeks Class II reclassification

Mirati begins dosage in MGCD265 Phase 1b clinical trial for NSCLC

EMA validates Synageva's sebelipase alfa MAA for LAL Deficiency

Radiation/chemotherapy increases risk of leukemia in early-stage breast cancer patients

Pivotal trial of Elios melanoma vaccine to be conducted at top U.S. cancer hospitals

Endogenous retroviruses play critical role in body's immune defense against bacterial, viral pathogens

Treatment for stroke: Intra-arterial treatment more effective than standard medical care for clot removal

Study reveals why older people are at higher risk for developing cancer

Research shows modern humans have less bone density than earlier human ancestors

First two patients enrolled in AGA’s GERD Registry successfully undergo treatment

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

Data management challenges in scientific research

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