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Alteration in tumor suppressor gene TP53 plays key role early in development of bone cancer

The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project found mutations in the tumor suppressor gene TP53 in 90 percent of osteosarcomas, suggesting the alteration plays a key role early in development of the bone cancer.

4 Apr 2014

Walking reduces high risk for heart disease in patients with kidney infection

Heart disease and infection are major complications and the leading causes of death in patients with chronic kidney disease. It is now well established that immune system dysfunction is involved in both of these pathological processes.

4 Apr 2014

Inhibiting cancer-promoting prolactin causes unconventional cell death in preclinical research

Under stress from chemotherapy or radiation, some cancer cells dodge death by consuming a bit of themselves, allowing them to essentially sleep through treatment and later awaken as tougher, resistant disease.

4 Apr 2014

Researcher pinpoints error in protein formation that could be root of amyotrophic lateral sclerosis

By studying nerve cells that originated in patients with a severe neurological disease, a University of Wisconsin-Madison researcher has pinpointed an error in protein formation that could be the root of amyotrophic lateral sclerosis.

4 Apr 2014

Cigarette smoking among obese women appears to interfere with ability to taste fats, sweets, says study

Cigarette smoking among obese women appears to interfere with their ability to taste fats and sweets, a new study shows. Despite craving high-fat, sugary foods, these women were less likely than others to perceive these tastes, which may drive them to consume more calories.

4 Apr 2014

Kidney disease patients with poor quality of life at increased risk of developing heart problems

Kidney disease patients with poor quality of life are at increased risk of experiencing progression of their disease and of developing heart problems, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology. The findings suggest that quality of life measurements may have important prognostic value in these individuals.

4 Apr 2014

Aortic valve replacement now possible without open-heart surgery

Loyola University Medical Center is the first hospital in Illinois to implant a newly approved aortic heart valve device that does not require open surgery.

From Medtronic 4 Apr 2014

Eating watermelon reduces blood pressure in overweight individuals

Be sure to pick up a watermelon - or two - at your neighborhood farmers' market. It could save your life.

4 Apr 2014

Sanford-Burnham to present new cancer research data at AACR 2014

Sanford-Burnham Medical Research Institute will present a wide range of new research data at the annual American Association for Cancer Research Meeting in San Diego starting Saturday, April 5, at the San Diego Convention Center. The presentations will cover a variety of topics including breast, melanoma, and prostate cancer, as well as novel methods of delivering drugs to tumors.

4 Apr 2014

Scientists develop new resuscitation protocols for birth asphyxia seizures

During birth, the baby has to stop depending on the placenta and start breathing on his or her own. If there are problems during the birth process, the baby may spend a period of time in the pathological condition of asphyxia, where the oxygen levels in the blood are much lower and carbon dioxide levels are much higher than expected.

4 Apr 2014

FDA approves expanded use Dyax’s KALBITOR in treatment of acute hereditary angioedema

Dyax Corp. today announced that the U.S. Food and Drug Administration (FDA) has approved an expansion of the indication for KALBITOR (ecallantide), a peptide inhibitor of plasma kallikrein used in the treatment of acute hereditary angioedema (HAE) attacks, to include patients 12 years of age and older.

4 Apr 2014

Harvard stem cell scientists discover potential treatment for amyotrophic lateral sclerosis

Harvard stem cell scientists have discovered that a recently approved medication for epilepsy may possibly be a meaningful treatment for amyotrophic lateral sclerosis (ALS)-Lou Gehrig's disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital to design an initial clinical trial testing the safety of the treatment in ALS patients.

4 Apr 2014

UCSF/Daiichi Sankyo establish drug-discovery collaboration focused on neurodegenerative diseases

Daiichi Sankyo Co., Ltd. (hereafter, Daiichi Sankyo) and UC San Francisco (UCSF) announced today that they have established a drug-discovery collaboration focused on developing novel therapeutics and molecular diagnostics for multiple neurodegenerative diseases.

4 Apr 2014

Scientists battle against cancer with nanoballoons and lasers

Chemotherapeutic drugs excel at fighting cancer, but they're not so efficient at getting where they need to go.

4 Apr 2014

Chordoma Foundation grants $75,000 to support development of new mouse model for bone cancer research

The Chordoma Foundation has made a seed grant of $75,000 to Adrienne Flanagan, M.D., Ph.D., of University College, London, and her Jackson Laboratory collaborator, Mike Sasner, Ph.D., to develop a new mouse model for chordoma, a difficult-to-treat bone cancer affecting the skull and spine.

3 Apr 2014

Neurovance closes $6.3M extension to its series A1 financing round to advance development of EB-1020 SR

Neurovance, Inc. today announced that it has closed a $6.3 million extension to its series A1 financing round to further advance development of EB-1020 SR, a non-stimulant, for the treatment of all subtypes of adult ADHD (attention deficit hyperactivity disorder).

3 Apr 2014

FDA clears Omeros' OMS721 IND for inhibition of complement‑mediated TMAs

Omeros Corporation today announced that its Investigational New Drug Application (IND) to evaluate OMS721 for the inhibition of complement‑mediated thrombotic microangiopathies (TMAs) has been cleared by the U.S. Food and Drug Administration.

3 Apr 2014

BDSI enrolls first patient in Clonidine Topical Gel Phase 3 trial for treatment of painful diabetic neuropathy

BioDelivery Sciences International, Inc. announced today the enrollment of the first patient in the RHAPSODY Study, a Phase 3 clinical trial of Clonidine Topical Gel for the treatment of painful diabetic neuropathy.

3 Apr 2014

Ketamine offers novel treatment for patients with severe depression

New data show ketamine (a drug widely used for anaesthesia and pain relief) has a rapid antidepressant effect in some patients with severe depression. The first UK study of ketamine intravenous infusions in people with treatment-resistant depression was conducted by the Oxford Health NHS Foundation Trust and the University of Oxford.

3 Apr 2014

Study sheds light on brain mechanisms that make schizophrenia patients misinterpret what they see

People with schizophrenia often misinterpret what they see and experience in the world. New research provides insight into the brain mechanisms that might be responsible for this misinterpretation.

3 Apr 2014

Medical Condition News

Alteration in tumor suppressor gene TP53 plays key role early in development of bone cancer

Walking reduces high risk for heart disease in patients with kidney infection

Inhibiting cancer-promoting prolactin causes unconventional cell death in preclinical research

Researcher pinpoints error in protein formation that could be root of amyotrophic lateral sclerosis

Cigarette smoking among obese women appears to interfere with ability to taste fats, sweets, says study

Kidney disease patients with poor quality of life at increased risk of developing heart problems

Aortic valve replacement now possible without open-heart surgery

Eating watermelon reduces blood pressure in overweight individuals

Sanford-Burnham to present new cancer research data at AACR 2014

Scientists develop new resuscitation protocols for birth asphyxia seizures

FDA approves expanded use Dyax’s KALBITOR in treatment of acute hereditary angioedema

Harvard stem cell scientists discover potential treatment for amyotrophic lateral sclerosis

UCSF/Daiichi Sankyo establish drug-discovery collaboration focused on neurodegenerative diseases

Scientists battle against cancer with nanoballoons and lasers

Chordoma Foundation grants $75,000 to support development of new mouse model for bone cancer research

Neurovance closes $6.3M extension to its series A1 financing round to advance development of EB-1020 SR

FDA clears Omeros' OMS721 IND for inhibition of complement‑mediated TMAs

BDSI enrolls first patient in Clonidine Topical Gel Phase 3 trial for treatment of painful diabetic neuropathy

Ketamine offers novel treatment for patients with severe depression

Study sheds light on brain mechanisms that make schizophrenia patients misinterpret what they see

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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