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Hi-C sequencing decodes 3-D structure of DNA folds in chromosomes

Chromosomes are strands of DNA that contain the blueprint of all living organisms. Humans have 23 pairs of chromosomes that instruct how genes are regulated during development of the human body. While scientists have developed an understanding of the one-dimensional structure of DNA, until today, little was known about how different parts of DNA are folded next to each other inside the nucleus.

12 Apr 2012

First clinical trial to clearly demonstrate effective prevention of post-ERCP pancreatitis

A study in the current issue of the New England Journal of Medicine shows a serious complication of ERCP, a procedure commonly used to diagnose and treat problems of the bile and pancreatic ducts, may be eliminated with a single dose medication.

12 Apr 2012

New compound reverses major symptoms associated with FXS

A recent study finds that a new compound reverses many of the major symptoms associated with Fragile X syndrome (FXS), the most common form of inherited intellectual disability and a leading cause of autism. The paper, published by Cell Press in the April 12 issue of the journal Neuron, describes the exciting observation that the FXS correction can occur in adult mice, after the symptoms of the condition have already been established.

12 Apr 2012

Two UM events examine timely issue of medicinal marijuana use

Two events this week at the University of Maryland Francis King Carey School of Law examine the timely issue of medicinal use of marijuana.

12 Apr 2012

Mayo Clinic experts available to discuss mental health challenges faced by cancer survivors

April is National Cancer Control Month, which focuses on the prevention, detection, and treatment of cancer and on efforts to improve the quality of life of the more than 11 million cancer survivors in the United States.

12 Apr 2012

Study looks at how personality traits might influence what and how people remember

We all have them - positive memories of personal events that are a delight to recall, and painful recollections that we would rather forget. A new study reveals that what we do with our emotional memories and how they affect us has a lot to do with our gender, personality and the methods we use (often without awareness) to regulate our feelings.

12 Apr 2012

Number of people worldwide with dementia expected to triple by 2050; Caregivers need support, report says

The number of people living with dementia is expected to double to 65.7 million by 2030 and more than triple by 2050, with "the current estimated cost of treating and caring for those with the condition at $604 billion a year," according to a report released Wednesday by the WHO and Alzheimer's Disease International, Agence France-Presse reports.

12 Apr 2012

Experts share top 5 springtime fruits and vegetables that fight cancer

The price of springtime fruits and vegetables seems to increase each year. But when buyers break this expense down to cents, they realize stocking up on these cancer-fighting foods still makes economical sense, say experts from The University of Texas MD Anderson Cancer Center.

12 Apr 2012

KineMed receives NIH RAID grant to advance FX-5A for heart disease

KineMed Inc. today announced its successful award of a Rapid Access to Intervention Development (RAID) peer-reviewed grant by the National Institute of Health to advance an HDL mimetic, designated FX-5A, designed to reverse atherosclerosis and heart disease.

12 Apr 2012

RiboMed releases multi-marker methylation prognostic test for glioma

RiboMed Clinical Services Laboratory (RCSL), a CLIA-certified subsidiary of RiboMed Biotechnologies, today announced the release of a multi-marker methylation prognostic test for grading gliomas, the most common type of brain cancer.

12 Apr 2012

Johns Hopkins cardiologists support use of statins for primary prevention of heart attack

Writing the first commentary for a new feature in the Journal of the American Medical Association (JAMA), called Viewpoint, Johns Hopkins cardiologists make the case for why a 55-year-old man with a 10 percent estimated risk of heart attack over the next 10 years should be offered statin medication. They were invited to debate a professor who argues against prescribing statins for "primary" prevention—for those who have not had a cardiovascular event, such as a heart attack—even though they may be considered at "intermediate" risk because of elevated cholesterol or other factors.

12 Apr 2012

Research explores power of offering colon cancer screening options

Researchers find that when given a choice of methods, more people will opt to get screened for colon cancer. Meanwhile, a separate study found that insurance coverage of lung cancer screenings for high-risk patients could prevent -- at a low cost -- thousands of deaths annually.

12 Apr 2012

USPTO issues two Notices of Allowance to AcelRx for NanoTab formulations

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of acute and breakthrough pain, today announced that the U.S. Patent and Trademark Office (USPTO) has issued AcelRx two Notices of Allowance for the patent applications entitled "Small-Volume Oral Transmucosal Dosage Forms" and "Bioadhesive Drug Formulations for Oral Transmucosal Delivery."

12 Apr 2012

Education tool helps chest pain patients decide on stress testing

Chest pain patients educated about their future heart attack risk and involved in deciding care options were more likely than less-aware patients to opt out of stress testing, according to research in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.

12 Apr 2012

Scientists aim to develop new testing methods for drug-induced liver failure

Liver damage caused by medicinal drugs is one of the most common reasons for liver failure and liver transplants in the Western world. Nevertheless, it is difficult to predict which active ingredients will turn out to be toxic for the organ. Oftentimes the problems are not discovered until the drug is already on the market. Prof. Dr. Jens Timmer, Freiburg physicist and Director of the FRIAS School of Life Sciences - LifeNet, is a project partner in a consortium that wants to solve this problem.

12 Apr 2012

People with PNES do not necessarily experience more frequent or severe stressful events

Based on their clinical experience and observations, a team of Johns Hopkins physicians and psychologists say that more than one-third of the patients admitted to The Johns Hopkins Hospital's inpatient epilepsy monitoring unit for treatment of intractable seizures have been discovered to have stress-triggered symptoms rather than a true seizure disorder.

12 Apr 2012

Four abstracts on spatial neglect to be presented at upcoming AAN meeting

Anna M. Barrett, MD will represent Kessler Foundation's Stroke Rehabilitation Research Laboratory at the upcoming American Academy of Neurology Conference at the Ernest N. Morial Convention Center in New Orleans, LA, April 21 - April 28.

12 Apr 2012

U.S. spends more on cancer care, but gains time in return

A new analysis published in Health Affairs found that American cancer patients lived almost two years longer than those in 10 European countries -- leading the researchers to say that the additional expense is worth it.

12 Apr 2012

ECG abnormalities associated with increased risk of CHD in older adults

In a study that included elderly men and women without preexisting cardiovascular disease, major and minor electrocardiographic abnormalities were associated with an increased risk of coronary heart disease (CHD) events and improved the prediction of CHD events such as heart attack, beyond traditional cardiovascular risk factors, according to a study in the April 11 issue of JAMA.

12 Apr 2012

TBI can negatively affect medical decision-making capacity

A traumatic brain injury can negatively affect a patient's medical decision-making ability at a time when patients or their families must make myriad complex decisions, say researchers from the University of Alabama at Birmingham.

12 Apr 2012