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Denosumab delays skeletal-related side effects in patients with breast cancer and bone metastases

For patients with breast cancer and bone metastases, denosumab delayed skeletal-related side effects five months longer compared to those on zoledronic acid, according to results presented at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 8-12.

13 Dec 2010

Researchers generate insulin-secreting pancreatic islet cells from human SSCs

Insulin-secreting pancreatic islet cells have been generated from human spermatogonial stem cells (SSCs) directly isolated from human testicular tissue, researchers reported today at the American Association of Cell Biology 50th Annual Meeting in Philadelphia.

13 Dec 2010

HOXB7 gene raises tamoxifen resistance in women with early-stage breast cancer

A gene target for drug resistance, a triple-drug cocktail for triple negative breast cancer, and patients' risk for carpal tunnel syndrome are among study highlights scheduled to be presented by Johns Hopkins Kimmel Cancer Center scientists during the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 8-12.

13 Dec 2010

Stem cell therapy can reduce risk of acute leukemia in affected individuals

Some adults and children with acute leukemia could benefit from certain transplants of blood stem cells, but the benefits are not equal across all cases of leukemia, according to a new review of 15 studies.

13 Dec 2010

Researchers present Phase III study of neoadjuvant therapy with trastuzumab and lapatinib for early breast cancer

Researchers presented Phase III efficacy data from the GeparQuinto study, a head-to-head comparison of neoadjuvant lapatinib and trastuzumab in combination with chemotherapy for patients with early breast cancer, at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 8-12.

13 Dec 2010

Cesarean-section deliveries may lead to degenerative back disease

Researchers from Michigan State University are studying whether pregnancies, specifically cesarean-section deliveries, are linked to a degenerative back disease that affects women three to nine times more often than men.

13 Dec 2010

Men with type 1 diabetes could grow their own insulin-producing cells from testicular tissue, says GUMC

Men with type 1 diabetes may be able to grow their own insulin-producing cells from their testicular tissue, say Georgetown University Medical Center (GUMC) researchers who presented their findings today at the American Society of Cell Biology 50th annual meeting in Philadelphia.

13 Dec 2010

High CTC level found to be early marker of poor outcome in metastatic breast cancer

A high level of circulating tumor cells (CTCs) - cells that have detached from a tumor and are circulating in the body through the blood - are an independent prognostic marker in metastatic breast cancer as first-line therapy.

13 Dec 2010

Genetic changes in HDAC9 gene may modulate onset of ER positive breast cancer and its recurrence

Investigators at The Cancer Institute of New Jersey have presented new research at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium. Their work highlights how a variation in a person's DNA sequence is associated with an earlier age of onset for breast cancer that is stimulated by the hormone estrogen (estrogen receptor positive).

13 Dec 2010

Depression drug appears effective in reducing pain associated with breast cancer treatment

A drug commonly used to treat depression and anxiety disorder was effective at reducing joint and muscle pain associated with a breast cancer treatment, according to a study from the University of Michigan Comprehensive Cancer Center.

12 Dec 2010

Medication for depression ended before recommended time

Swedish women's use of antidepressants is twice as high as that of Swedish men. However, among both female and male new users, one fifth fills only one prescription. "This can be an indication of choices being made to end treatment before the recommended time," says researcher Karolina Andersson Sundell at the Nordic School of Public Health.

10 Dec 2010

OPTN arranges first paired donation of living donor kidneys

Kathy Niedzwiecki of Pelham, NH, and Ken Crowder of St. Louis are experiencing renewed life and health thanks to the generosity of two living kidney donors.

10 Dec 2010

Sound masking therapy is of uncertain benefit when used alone to treat tinnitus

Tinnitus — what many think of as "ringing in the ears" — is the perception of sound without any real acoustic stimulation. Sound masking therapy, a common component of tinnitus treatment, is of uncertain benefit when used on its own, a new evidence review finds.

10 Dec 2010

Stroke falls from third to fourth leading cause of death

A new report, "Deaths: Preliminary Data for 2008," released by the Centers for Disease Control and Prevention (CDC), says that for the first time in 50 years, stroke has fallen from the third to the fourth leading cause of death.

10 Dec 2010

MMI-USA announces limited launch of new Smart Toe II Hammertoe Fixation System

MMI-USA, a subsidiary of Memometal Technologies S.A., a global orthopaedic manufacturer headquartered in France, announces the limited launch of the new Smart Toe® II Hammertoe Fixation System. The product becomes an important piece of a comprehensive system for forefoot fixation, and reinforces the most widely used franchise of intramedullary implants of this kind in the world.

10 Dec 2010

Pfizer withdraws Thelin for treatment of PAH, discontinues global clinical studies

Pfizer Inc. announced today that, in the interest of patient safety, it is voluntarily withdrawing Thelin® (sitaxentan) for the treatment of pulmonary arterial hypertension (PAH) in regions where it is approved (the European Union, Canada and Australia). In addition, Pfizer is discontinuing clinical studies of Thelin worldwide.

10 Dec 2010

Arena initiates dosing in APD811 Phase 1 clinical trial for pulmonary arterial hypertension

Arena Pharmaceuticals, Inc. announced today the initiation of dosing in a Phase 1 clinical trial of APD811, a novel oral drug candidate discovered by Arena that targets the prostacyclin receptor for the treatment of pulmonary arterial hypertension, or PAH.

10 Dec 2010

31-year-old mother with Gorham-Stout syndrome goes home with virtually rebuilt spine

Laurie Harms, Los Angeles, feared she'd never hold her infant daughter, Sky, again. A devastating and extremely rare bone-eroding disease - Gorham-Stout syndrome - had left the 31-year-old crumpled in a hospital bed - her neck broken, arms limp and useless, and voice muted by tubes.

10 Dec 2010

Ipilimumab in combination with paclitaxel/carboplatin for stage IIIb/IV NSCLC shows superior results

Ipilimumab used in combination with paclitaxel/carboplatin for stage IIIb/IV non-small cell lung cancer showed superior results in progression free survival when compared to paclitaxel/carboplatin alone, according to research presented at the 2010 Chicago Multidisciplinary Symposium in Thoracic Oncology. This symposium is sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO), the International Association for the Study of Lung Cancer (ISLAC) and the University of Chicago.

10 Dec 2010

Repeated cerebral trauma in boxing career may result in boxer's dementia

Up to 20% of professional boxers develop neuropsychiatric sequelae. But which acute complications and which late sequelae can boxers expect throughout the course of their career? These are the questions studied by Hans Förstl from the Technical University Munich and his co-authors in the current issue of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2010; 107[47]: 835-9).

10 Dec 2010

Medical Condition News

Denosumab delays skeletal-related side effects in patients with breast cancer and bone metastases

Researchers generate insulin-secreting pancreatic islet cells from human SSCs

HOXB7 gene raises tamoxifen resistance in women with early-stage breast cancer

Stem cell therapy can reduce risk of acute leukemia in affected individuals

Researchers present Phase III study of neoadjuvant therapy with trastuzumab and lapatinib for early breast cancer

Cesarean-section deliveries may lead to degenerative back disease

Men with type 1 diabetes could grow their own insulin-producing cells from testicular tissue, says GUMC

High CTC level found to be early marker of poor outcome in metastatic breast cancer

Genetic changes in HDAC9 gene may modulate onset of ER positive breast cancer and its recurrence

Depression drug appears effective in reducing pain associated with breast cancer treatment

Medication for depression ended before recommended time

OPTN arranges first paired donation of living donor kidneys

Sound masking therapy is of uncertain benefit when used alone to treat tinnitus

Stroke falls from third to fourth leading cause of death

MMI-USA announces limited launch of new Smart Toe II Hammertoe Fixation System

Pfizer withdraws Thelin for treatment of PAH, discontinues global clinical studies

Arena initiates dosing in APD811 Phase 1 clinical trial for pulmonary arterial hypertension

31-year-old mother with Gorham-Stout syndrome goes home with virtually rebuilt spine

Ipilimumab in combination with paclitaxel/carboplatin for stage IIIb/IV NSCLC shows superior results

Repeated cerebral trauma in boxing career may result in boxer's dementia

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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