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In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients

A recent systematic review and meta-analysis evaluated the safety and efficacy of intensified anticoagulation therapy in COVID-19 patients.

11 Mar 2022

Study indicates a 100 µg mRNA-1273 booster has acceptable safety and robust antibody response against SARS-CoV-2

A recent study assessed the safety and immunogenicity of mRNA-1273 booster vaccine against COVID-19.

11 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Researchers assessed the increase in Pfizer/BioNTech BNT162b2 vaccine efficacy on administering a homologous booster dose.

11 Mar 2022

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Researchers evaluated the immune responses after boosting with Pfizer's BNT162b2 vaccine.

11 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Researchers observed that Golgi fragmentation induced by SARS-CoV-2 facilitates viral trafficking.

11 Mar 2022

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Researchers elucidated antiviral activities of aminoglycoside geneticin against seven SARS-CoV-2 variants using different cell lines and respiratory tissues.

11 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation - the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Study finds greater financial worries and lower rates of psychological distress among immigrants

Compared to US-born individuals, immigrants to the United States have increased financial worries – especially related to things like retirement and medical costs, reports a study in the March issue of the Journal of Psychiatric Practice.

11 Mar 2022

Child–mother attachment in toddlerhood moderates adolescents’ evaluation of trustworthiness

Interpersonal trust is a crucial component of healthy relationships. When we interact with strangers, we quickly gauge whether we can trust them. And those important social skills may be shaped by our earliest relationship with caregivers.

11 Mar 2022

Blood test shows promise to identify Alzheimer's changes in the brain before symptom onset

The University of Kentucky's Sanders-Brown Center on Aging has been around for nearly half a century. In that time, they have built an international reputation for best-in-class research into a disease that kills more people every year than breast and prostate cancer combined – Alzheimer's disease.

10 Mar 2022

Most cancer patients develop antibodies after receiving COVID-19 vaccine, study shows

Cancer patients who have compromised immune systems due to their disease or therapy remain at high risk for COVID-19 infection.

10 Mar 2022

Prenatal mindfulness intervention may improve health outcomes in offspring, study shows

Infants whose mothers participated in a mindfulness-based program during pregnancy had healthier stress responses at 6 months old, a new UC San Francisco study found.

10 Mar 2022

Researchers identify motor neuron toxin associated with ALS

An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) contributes to the motor neuron death that is the signature of these diseases.

10 Mar 2022

Damage to the inner ear system linked to fall risk among Alzheimer’s patients

A Johns Hopkins Medicine study of about 50 people with Alzheimer's disease has added to evidence that damage to the inner ear system that controls balance is a major factor in patients' well-documented higher risk of falling.

10 Mar 2022

New study analyzes COVID-19 outcomes in patients with cancer

If a cancer patient tests positive for COVID-19, are they more likely to become hospitalized from the disease?

10 Mar 2022

Study finds fewer COVID-19 cases in schools with mandatory masking during Delta surge

Schools with mandatory masking during the Delta surge had approximately 72% fewer cases of in-school transmission of SARS-CoV-2 when compared to schools with optional or partial masking policies, according to a study funded by the National Institutes of Health.

10 Mar 2022

Medical Research News

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients

Study indicates a 100 µg mRNA-1273 booster has acceptable safety and robust antibody response against SARS-CoV-2

Novel genetic relationships with severe SARS-CoV-2

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Study finds greater financial worries and lower rates of psychological distress among immigrants

Child–mother attachment in toddlerhood moderates adolescents’ evaluation of trustworthiness

Blood test shows promise to identify Alzheimer's changes in the brain before symptom onset

Most cancer patients develop antibodies after receiving COVID-19 vaccine, study shows

Prenatal mindfulness intervention may improve health outcomes in offspring, study shows

Researchers identify motor neuron toxin associated with ALS

Damage to the inner ear system linked to fall risk among Alzheimer’s patients

New study analyzes COVID-19 outcomes in patients with cancer

Study finds fewer COVID-19 cases in schools with mandatory masking during Delta surge

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

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