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Pioneering study could transform the treatment landscape for babies with infantile spasms

Infantile spasm (IS) is a severe epileptic syndrome of infancy and accounts for 50% of all epilepsy cases that occur in babies during the first year of life.

20 May 2022

New analysis finds increase in success and efficiency of chronic total occlusion percutaneous coronary intervention

A new analysis of PROGRESS-CTO (PROspective Global REgiStry for the Study of Chronic Total Occlusion Intervention; www.progresscto.org), an international multi-center registry of chronic total occlusion (CTO) percutaneous coronary intervention (PCI), was presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2022 Scientific Sessions.

20 May 2022

Study finds no difference in survival between patients treated with paclitaxel drug-coated devices and non-DCDs

New long-term data from the Safety Assessment of Femoropopliteal Endovascular Treatment With PAclitaxel-coated Devices (SAFE-PAD) study were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2022 Scientific Sessions.

20 May 2022

APOB-specific T cells may contribute to inflammation and further the progression of atherosclerosis

Preventing atherosclerosis, the underlying cause of heart disease, means scientists need to understand how immune cells drive inflammation in the arteries.

20 May 2022

Discoveries may lead to new ways to treat patients with Allan-Herndon-Dudley syndrome

Two recent discoveries co-led by scientists at Cedars-Sinai may help lead to new ways to treat patients with Allan-Herndon-Dudley syndrome (AHDS), a brain development disorder that causes severe intellectual disability and problems with movement.

20 May 2022

Liver acuity circle allocation policy associated with procurement delays

A national policy change to facilitate the broader sharing of donor livers through "acuity circles" has resulted in procurement delays, according to a researcher at the University of Miami Miller School of Medicine.

20 May 2022

Warmer-than-average temperatures erode human sleep, study shows

Most research looking at the impact of climate change on human life has focused on how extreme weather events affect economic and societal health outcomes on a broad scale.

20 May 2022

Molecular target discovery opens new pathways for developing effective anti-angiogenic cancer therapy

Researchers with The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have identified a new molecular drug target that could result in new cancer drugs with fewer side effects.

20 May 2022

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5.

20 May 2022

Expressions of doubt are vital for promoting trust in vaccines, research reveals

Groundbreaking new University of Limerick, Ireland research analyzing global vaccine hesitancy has revealed that expressions of doubt are essential for promoting trust in vaccines.

20 May 2022

Study outlines risk factors for autoimmune hepatitis after liver transplant

A multicenter study performed by a large international consortium that includes UT Southwestern has outlined a set of risk factors and outcomes for patients with autoimmune hepatitis (AIH) that recurs after liver transplantation.

20 May 2022

Blood-based biomarker can predict the benefit of immunotherapy to lung cancer patients

A blood-based tumor biomarker can predict the benefit of immunotherapy to patients with non-small cell lung cancer, according to a study published in Nature Medicine.

20 May 2022

Exploring the possibility of whether surface ACE2 carried by extracellular vesicles can facilitate SARS-CoV-2 infection

Researchers explored whether surface ACE2 carried by EVs can facilitate the entry of SARS-CoV-2 into host cells.

20 May 2022

Important methodology for targeting conserved epitopes of SARS-CoV-2 and an immune-focused approach in pan-sarbeco and universal CoV vaccine design

A new study has focused on designing immunogens associated with the conserved region of the spike protein of SARS-CoV-2.

20 May 2022

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

A new study has revealed that ATV006, which is a 5′-hydroxyl-isobutyryl prodrug, possesses extraordinary oral pharmaco-kinetic (PK) profiles in rats and cynomolgus monkeys and exhibited significant antiviral activity against ancestral SARS-COV-2 strain as well as VOCs.

20 May 2022

The link between androgens and COVID-19

A new paper examines the association between androgens and COVID-19, as revealed by the research carried out on this topic throughout the pandemic.

20 May 2022

Study explores if prior infection with SARS-CoV-2 increased sensitivity to a mitochondrial toxin known to induce parkinsonism

The authors of the current study looked at the potential for an increased risk of parkinsonism following a bout of SARS-CoV-2 infection through accepted post-viral mechanisms.

20 May 2022

Hyperinsulinemic patients with breast cancer may be responsive to metabolism-targeting treatments

Scientists at Yale Cancer Center have found that patients with breast cancer and high levels of insulin in the blood may be responsive to metabolism-targeting treatments, which in turn may improve the effectiveness of subsequent chemotherapy treatments.

20 May 2022

Study tests whether the political climate in each US state and Washington, DC determined the nature of the spread of COVID-19 cases and deaths during 2020

Researchers assessed the association of the spread of coronavirus disease 2019 (COVID-19) with the political climate in the US in 2020.

20 May 2022

Long-term insomnia symptoms associated with poor cognitive functioning in old age

The Helsinki Health Study at the University of Helsinki investigated the development of insomnia symptoms in midlife and their effects on memory, learning ability and concentration after retirement. The follow-up period was 15–17 years.

20 May 2022

Medical Research News

Pioneering study could transform the treatment landscape for babies with infantile spasms

New analysis finds increase in success and efficiency of chronic total occlusion percutaneous coronary intervention

Study finds no difference in survival between patients treated with paclitaxel drug-coated devices and non-DCDs

APOB-specific T cells may contribute to inflammation and further the progression of atherosclerosis

Discoveries may lead to new ways to treat patients with Allan-Herndon-Dudley syndrome

Liver acuity circle allocation policy associated with procurement delays

Warmer-than-average temperatures erode human sleep, study shows

Molecular target discovery opens new pathways for developing effective anti-angiogenic cancer therapy

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

Expressions of doubt are vital for promoting trust in vaccines, research reveals

Study outlines risk factors for autoimmune hepatitis after liver transplant

Blood-based biomarker can predict the benefit of immunotherapy to lung cancer patients

Exploring the possibility of whether surface ACE2 carried by extracellular vesicles can facilitate SARS-CoV-2 infection

Important methodology for targeting conserved epitopes of SARS-CoV-2 and an immune-focused approach in pan-sarbeco and universal CoV vaccine design

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

The link between androgens and COVID-19

Study explores if prior infection with SARS-CoV-2 increased sensitivity to a mitochondrial toxin known to induce parkinsonism

Hyperinsulinemic patients with breast cancer may be responsive to metabolism-targeting treatments

Study tests whether the political climate in each US state and Washington, DC determined the nature of the spread of COVID-19 cases and deaths during 2020

Long-term insomnia symptoms associated with poor cognitive functioning in old age

Membrane proteins in focus: Turning high-risk targets into routine workflows

How metabolic phenotyping can detect viral infections in minutes

Directed enzyme evolution and the Nobel Prize: Making enzymes evolve in the lab

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