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Frameshift deletion mutation in ORF7a may provide fitness advantage to Australia's SARS-CoV-2 delta variants

A team of scientists from Australia has recently identified a frameshift deletion mutation in ORF7a of the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mutation results in the production of a truncated peptide with altered functionality. The study is currently available on the medRxiv* preprint server while awaiting peer review.

24 Aug 2021

Study shows higher risk of sarcopenia among older adults who are underweight and lack exercise

Analysis of medical data from around 1800 65-year-old residents of Kobe, a large Japanese city, has shown that at least 3% have possible sarcopenia (*1), revealing that the risks are higher in those who are underweight and don't exercise enough.

24 Aug 2021

Study suggests a novel therapeutic target to reverse lung fibrosis

Researchers have reversed lung fibrosis in a mouse model of idiopathic pulmonary fibrosis, or IPF, as reported in a study published in the journal Cell Death and Differentiation.

24 Aug 2021

Patients on dialysis show reduced antibody levels four months after COVID-19 vaccination

A new longitudinal study posted to the medRxiv* preprint server suggests vaccinated patients on chronic hemodialysis having waning immunity against severe acute respiratory syndrome 2 (SARS-CoV-2) variants of concern. The German researchers found a drop in neutralizing antibody levels and T cell activity four months after receiving their second Pfizer-BioNTech vaccine.

24 Aug 2021

Extreme novel pandemics more likely to occur in the future, statistical study reveals

The COVID-19 pandemic may be the deadliest viral outbreak the world has seen in more than a century. But statistically, such extreme events aren't as rare as we may think, asserts a new analysis of novel disease outbreaks over the past 400 years.

24 Aug 2021

Synthetic SARS-CoV-2 vs. SARS-CoV-2

Though vaccination efforts are underway in most countries, there are still limited options for treating COVID-19. Now, researchers at Penn State designed a new COVID-19 therapy that uses a defective synthetic version of the SARS-CoV-2 virus to interfere with the actual virus's replication.

23 Aug 2021

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

By applying a systems biology approach, a recent bioRxiv* preprint research paper by scientists from the Icahn School of Medicine at Mount Sinai in New York unveils interactions between the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and p38 mitogen-activated protein kinase (MAPK) pathway responsible for regulating the expression of crucial inflammatory mediators in human lung epithelial cells.

23 Aug 2021

Study suggests algorithm may help optimize future COVID-19 vaccine design

Scientists predict the COVID-19 pandemic is on its way to becoming endemic. The rising spread of COVID-19 variants such as Delta has helped infect unvaccinated and some vaccinated individuals. COVID-19 vaccines continue to be the best way to protect against severe illness and death, but there may be a need for vaccines to protect against a specific variant.

23 Aug 2021

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Researchers at Children's National Hospital identified a vulnerability in a developmental signaling pathway that can be hijacked to drive pediatric low-grade glioma (pLGG) formation, according to a pre-clinical study published in Developmental Cell.

23 Aug 2021

Study identifies a novel potential biomarker for hepatocellular carcinoma

Aging-US published "Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for hepatocellular carcinoma" which reported that there is still a lack of comprehensive analysis of the circular RNA -long non-coding RNA -miRNA-mRNA ceRNA network in hepatocellular carcinoma.

23 Aug 2021

Feeling like leisure is wasteful may lead to poorer mental health outcomes, research suggests

Feeling like leisure is wasteful and unproductive may lead to less happiness and higher levels of stress and depression, new research suggests.

23 Aug 2021

COVID booster shots might be needed in subgroup of HIV-positive individuals

The coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a global pandemic destroying lives and economies. COVID-19 is not curable, so vaccines are the only safeguard during this pandemic.

23 Aug 2021

Study: Awake prone positioning can reduce the need for mechanical ventilation in COVID-19 patients

A six country clinical study of more than 1,100 hospitalized COVID-19 patients who required high-flow nasal cannula oxygen therapy suggests that prone positioning (rotating patients with severe breathing issues so they are face down) soon after admission can significantly reduce the need for mechanical ventilation.

23 Aug 2021

Researchers unravel pathomechanisms involved in Chronic Fatigue Syndrome

ME (Myalgic Encephalopathy), also known as Chronic Fatigue Syndrome (CFS), can be a debilitating disease. It frequently presents after an infection, and key features are long-lasting fatigue and worsening of symptoms after exertion.

23 Aug 2021

SARS-CoV-2 alpha variant exhibits enhanced household transmission

In a recent study, the transmission rate of wildtype and the Alpha variant of SARS-CoV-2 through households is tracked.

23 Aug 2021

New mouse model may help elucidate the pathogenic mechanisms behind Sjögren's syndrome

Sjögren's syndrome is an autoimmune disease that attacks the tear system in the eyes and salivary glands, leading to patients experiencing extremely dry eyes and mouth.

23 Aug 2021

Broad-spectrum coronavirus neutralization amongst vaccinated SARS-CoV-1 survivors

The potency of neutralizing antibodies in individuals who have recovered from SARS-CoV and received the SARS-CoV-2 vaccine is evaluated.

23 Aug 2021

Personal Activity Intelligence can help people maintain a healthy body weight, study shows

New research shows that physical activity equivalent to 100 PAI a week can counteract excessive weight gain.

23 Aug 2021

Non-invasive retinal imaging may be useful for detecting Alzheimer's disease risk

Amyloid plaques are protein deposits that collect between brain cells, hindering function and eventually leading to neuronal death.

23 Aug 2021

Aerosol from vaping devices likely impairs blood vessel function, rat study shows

Aerosol generated from vaping devices likely impairs blood vessels' ability to function comparable to traditional cigarette smoke, according to preliminary research in rats presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2021.

23 Aug 2021

Medical Research News

Frameshift deletion mutation in ORF7a may provide fitness advantage to Australia's SARS-CoV-2 delta variants

Study shows higher risk of sarcopenia among older adults who are underweight and lack exercise

Study suggests a novel therapeutic target to reverse lung fibrosis

Patients on dialysis show reduced antibody levels four months after COVID-19 vaccination

Extreme novel pandemics more likely to occur in the future, statistical study reveals

Synthetic SARS-CoV-2 vs. SARS-CoV-2

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

Study suggests algorithm may help optimize future COVID-19 vaccine design

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Study identifies a novel potential biomarker for hepatocellular carcinoma

Feeling like leisure is wasteful may lead to poorer mental health outcomes, research suggests

COVID booster shots might be needed in subgroup of HIV-positive individuals

Study: Awake prone positioning can reduce the need for mechanical ventilation in COVID-19 patients

Researchers unravel pathomechanisms involved in Chronic Fatigue Syndrome

SARS-CoV-2 alpha variant exhibits enhanced household transmission

New mouse model may help elucidate the pathogenic mechanisms behind Sjögren's syndrome

Broad-spectrum coronavirus neutralization amongst vaccinated SARS-CoV-1 survivors

Personal Activity Intelligence can help people maintain a healthy body weight, study shows

Non-invasive retinal imaging may be useful for detecting Alzheimer's disease risk

Aerosol from vaping devices likely impairs blood vessel function, rat study shows

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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