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A promising drug delivery system for therapeutics that shut down harmful genes

Viruses attack the body by sending their genetic code -- DNA and RNA -- into cells and multiplying. A promising class of therapeutics that uses synthetic nucleic acids to target and shut down specific, harmful genes and prevent viruses from spreading is gaining steam.

18 May 2021

Stabilizing mutations in SARS-CoV-2 immunogens improve vaccine design

Researchers in the United States have developed stabilized immunogens presenting the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may improve the scalability of RBD-based coronavirus vaccines.

18 May 2021

Moderate therapeutic hypothermia does not improve neurological outcomes after cardiac arrest

In patients receiving therapeutic hypothermia after suffering out-of-hospital cardiac arrest, those who were cooled below 31 degrees Celsius (about 88 degrees Fahrenheit) for 24 hours showed no difference in terms of death or poor neurological outcomes at six months compared with patients receiving guideline-recommended cooling of 34 C (about 93 F).

18 May 2021

Sperm deliver signals to female reproductive tissues to increase the chances of conception

Sperm are generally viewed as having just one action in reproduction - to fertilize the female's egg - but studies at the University of Adelaide are overturning that view.

18 May 2021

Sotagliflozin reduces adverse cardiovascular events across patients with diabetes, heart failure

Patients with both diabetes and heart failure who were treated with sotagliflozin, a novel investigational drug for diabetes, for a median of nine to 16 months experienced reductions of 22% to 43% in the risk of death or worsening heart failure compared with similar patients who were treated with a placebo

18 May 2021

Dendritic cells can take a shortcut to reach the lymph nodes more quickly

In its response to pathogens and vaccines, our immune system relies on dendritic cells. These white blood cells patrol the body's tissues, collect components of pathogens and vaccines and transport them via lymphatic vessels to the nearest lymph node.

18 May 2021

Abnormal blood levels of proteins linked to dementia, Alzheimer's disease

The development of dementia, often from Alzheimer's disease, late in life is associated with abnormal blood levels of dozens of proteins up to five years earlier, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health

18 May 2021

Milder COVID-19 in children may be due to higher memory B cells responses to SARS-CoV-2

A new research paper published in the journal Science explores the differences in coronavirus-specific B memory cell repertoires in children versus adults, as well as the functional importance of this discovery.

18 May 2021

A potential treatment to prevent obesity-related liver damage

One of the especially dangerous health risks of being extremely overweight occurs when an obese person begins to accumulate fat in their liver.

18 May 2021

Omecamtiv mecarbil significantly reduces hospitalizations among patients with severe heart failure

The experimental heart failure drug omecamtiv mecarbil reduced heart failure hospitalizations by a greater margin among patients with more severely reduced ejection fraction, a measure indicating severe impairment in the heart's pumping ability, compared with those who had moderately reduced ejection fraction, according to research presented at the American College of Cardiology's 70th Annual Scientific Session.

18 May 2021

New technology tricks tumors to eliminate itself through the production of anti-cancer agents

Scientists at the University of Zurich have modified a common respiratory virus, called adenovirus, to act like a Trojan horse to deliver genes for cancer therapeutics directly into tumor cells. Unlike chemotherapy or radiotherapy, this approach does no harm to normal healthy cells.

18 May 2021

COVID-19 mRNA vaccines safe and effective for pregnant and breastfeeding women

The current coronavirus disease 2019 (COVID-19) pandemic has brought untold devastation in its wake, with its rapid and asymptomatic spread to hundreds of millions of people the world over. Vaccines have been hailed as the way out of this situation, and a dozen or so are being rolled out in many different countries.

18 May 2021

Researchers receive $4.5 million grant to improve quality of care for people with cardiovascular disease

Researchers from the University of Tennessee Health Science Center have received a $4.5 million grant over three years from the Agency for Healthcare Research and Quality (AHRQ) to lead a statewide network of primary care providers, health systems, and academic centers to identify, develop, and implement patient-centered approaches to improve quality of care and outcomes for people with cardiovascular disease.

18 May 2021

Breastfeeding safe and beneficial in SARS-CoV-2 infection

\With the onset of the coronavirus disease 2019 (COVID-19) pandemic, hundreds of millions of people became infected worldwide, including thousands of pregnant women near term. The question of vertical transmission to the infant via the placenta or breast milk was very real, leading to a near-total ban on breastfeeding in this group.

17 May 2021

Study raises more concerns about the use of combined EPA/DHA through supplements

Doctors often recommend Omega-3s to help patients lower their cholesterol and improve heart health. Those Omega-3s can come from fatty fish like salmon and mackerel, or supplements that often contain a combination of the acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

17 May 2021

Study provides valuable insight for preventing global pandemics

Whether it's plankton exposed to parasites or people exposed to pathogens, a host's initial immune response plays an integral role in determining whether infection occurs and to what degree it spreads within a population, new University of Colorado Boulder research suggests.

17 May 2021

Medical Research News

A promising drug delivery system for therapeutics that shut down harmful genes

Stabilizing mutations in SARS-CoV-2 immunogens improve vaccine design

Moderate therapeutic hypothermia does not improve neurological outcomes after cardiac arrest

Sperm deliver signals to female reproductive tissues to increase the chances of conception

Sotagliflozin reduces adverse cardiovascular events across patients with diabetes, heart failure

Dendritic cells can take a shortcut to reach the lymph nodes more quickly

Abnormal blood levels of proteins linked to dementia, Alzheimer's disease

Milder COVID-19 in children may be due to higher memory B cells responses to SARS-CoV-2

A potential treatment to prevent obesity-related liver damage

Omecamtiv mecarbil significantly reduces hospitalizations among patients with severe heart failure

New technology tricks tumors to eliminate itself through the production of anti-cancer agents

COVID-19 mRNA vaccines safe and effective for pregnant and breastfeeding women

Researchers receive $4.5 million grant to improve quality of care for people with cardiovascular disease

Breastfeeding safe and beneficial in SARS-CoV-2 infection

Study raises more concerns about the use of combined EPA/DHA through supplements

Study provides valuable insight for preventing global pandemics

Long-term prescription medication use may not improve disturbed sleep

Patients embrace telehealth-supported access to health care during the pandemic

Research reveals neural networks underlying imagination

Fasting diets could have detrimental effect on the health of future generations

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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