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Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells.

30 Mar 2021

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care.

30 Mar 2021

New machine learning technique reveals mutational signatures in cancer patients

Researchers at the Johns Hopkins Kimmel Cancer Center used machine learning techniques to detect mutational signatures in cancer patients.

30 Mar 2021

Using a salt substitute can help lower blood pressure in rural India

Replacing regular common salt consumed by hypertensive patients in rural areas with a salt substitute can have a significant impact in terms of lowering their blood pressure, a new study by The George Institute for Global Health has revealed.

30 Mar 2021

UCLA receives grant to study the effectiveness of COVID-19 vaccines among health care workers

The David Geffen School of Medicine at UCLA has received a $4.9 million grant from the Centers for Disease Control and Prevention to study the effectiveness of COVID-19 vaccines among health care workers.

30 Mar 2021

Adverse childhood experiences linked to adolescents' delinquent behaviors

About 61% of Americans have had at least one Adverse Childhood Experience (ACE), experts' formal term for a traumatic childhood event.

30 Mar 2021

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Primary sclerosing cholangitis (PSC) is a rare, chronic, inflammatory disease of the bile ducts and is difficult to treat, since its causes have not yet been adequately researched.

30 Mar 2021

Researchers examine the evolutionary race between SARS-CoV-2 and human defenses

Researchers have analyzed this evolution of the virus based on evolutionary ecology theory. Using the virus genomes available in the Global Initiative on Sharing Avian Influenza Data (GISAID) database, the researchers focused their inquiry on mutations in the receptor-binding domain (RBD) on the spike protein of SARS-CoV-2.

30 Mar 2021

Researchers develop novel test that screens for SARS-CoV-2 variants of concern

A team of scientists from the United States has recently developed a single-tube duplex molecular assay for rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants containing E484K and N501Y spike mutations.

30 Mar 2021

Imported COVID-19 cases responsible for spread of the UK and Brazil SARS-CoV-2 variants in Italy

A new study examines a major consequence of the second wave of COVID-19 infection—namely, the rapid emergence of new viral lineages and variants.

30 Mar 2021

Single dose of Pfizer and Oxford vaccines shows 60% efficacy in elderly care home residents

A new study deals with the effect of two widely used vaccines in eliciting humoral immunity against the virus in this group. These are the Oxford/AstraZeneca viral-vectored vaccine (ChAdOx1 nCoV-19), and the Pfizer/BioNTech’s messenger RNA-based vaccine (BNT162b2). Both express the viral spike antigen, and both are currently being employed in the UK’s vaccination program.

30 Mar 2021

Study finds rapid increase in IgG and IgA antibody levels following COVID-19 mRNA vaccination

A new study describes the kinetics of the antibody response to the earliest approved vaccines against COVID-19, which were developed on an mRNA platform.

30 Mar 2021

Researchers report on novel SARS-CoV-2 Israeli strain with unique spike glycoprotein

Researchers from Israel describe a novel SARS-CoV-2 strain with a non-synonymous mutation in its spike glycoprotein, designated as P681H; nevertheless, its emergence has not been associated with increased infections rate, facilitated spread or vaccine evasion.

30 Mar 2021

Researchers develop broadly neutralizing SARS-CoV-2 ferritin nanoparticle vaccine

In the continued need for next-generation vaccines that confer broad protection against COVID-19, scientists developed an adjuvanted SARS-CoV-2 Spike Ferritin Nanoparticle (SpFN) vaccine.

30 Mar 2021

Determination of vaccine-elicited SARS-CoV-2 antibodies in breastmilk

A new study has analyzed the levels of SARS-CoV-2 antibodies elicited by the novel COVID-19 vaccines in breastmilk.

30 Mar 2021

Study reveals a novel mechanism of circulatory response to stressful events

Researchers from the University of Tsukuba discover a novel mechanism by which the brain regulates the cardiovascular system in response to stress.

30 Mar 2021

Outdoor physical activity during increased air pollution may offset its beneficial effects

Physical activity is important in preventing heart and blood vessel disease in young people so long as they don't undertake very strenuous activity on days when air pollution levels are high, according to a nationwide study of nearly 1.5 million people published today (Tuesday) in the European Heart Journal.

30 Mar 2021

Strengths-based approach may attribute to positive outcomes in children with autism spectrum disorder

One of the biggest longitudinal research studies of its kind in the world led by The Hospital for Sick Children (SickKids) and the Centre for Addiction and Mental Health (CAMH) suggests that positive outcomes for children with autism spectrum disorder (ASD) are more common than previously thought.

30 Mar 2021

Study explains the link between psoriasis treatment and cardiovascular diseases

Patients with psoriasis, an autoimmune skin disorder, often have cardiovascular disorders as well. Hence, it is important for patients and clinicians to understand how treatments for psoriasis may influence cardiovascular disease risks.

30 Mar 2021

New molecular pathway helps steer moving cells in specific directions

Working with fruit flies, scientists at Johns Hopkins Medicine say they have identified a new molecular pathway that helps steer moving cells in specific directions.

30 Mar 2021

Medical Research News

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

New machine learning technique reveals mutational signatures in cancer patients

Using a salt substitute can help lower blood pressure in rural India

UCLA receives grant to study the effectiveness of COVID-19 vaccines among health care workers

Adverse childhood experiences linked to adolescents' delinquent behaviors

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Researchers examine the evolutionary race between SARS-CoV-2 and human defenses

Researchers develop novel test that screens for SARS-CoV-2 variants of concern

Imported COVID-19 cases responsible for spread of the UK and Brazil SARS-CoV-2 variants in Italy

Single dose of Pfizer and Oxford vaccines shows 60% efficacy in elderly care home residents

Study finds rapid increase in IgG and IgA antibody levels following COVID-19 mRNA vaccination

Researchers report on novel SARS-CoV-2 Israeli strain with unique spike glycoprotein

Researchers develop broadly neutralizing SARS-CoV-2 ferritin nanoparticle vaccine

Determination of vaccine-elicited SARS-CoV-2 antibodies in breastmilk

Study reveals a novel mechanism of circulatory response to stressful events

Outdoor physical activity during increased air pollution may offset its beneficial effects

Strengths-based approach may attribute to positive outcomes in children with autism spectrum disorder

Study explains the link between psoriasis treatment and cardiovascular diseases

New molecular pathway helps steer moving cells in specific directions

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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