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UAB lab to offer new tests for genetic diseases using next-generation sequencing

The Medical Genomics Laboratory at the University of Alabama at Birmingham is expanding its technological array with a new panel of diagnostic tests for genetic diseases known as neurofibromatoses and rasopathies. Beginning April 18, the UAB lab will offer new tests using the technique called customized deep-coverage, next-generation sequencing or NGS.

18 Apr 2016

Existing cancer drugs may be able to help people with enlarged heart cells

UT Southwestern Medical Center cardiology researchers have identified molecular ties between the growth of cancer cells and heart cells that suggest existing cancer drugs may be able to help those with enlarged heart cells -- a condition that can lead to heart attacks and stroke.

18 Apr 2016

Noise in concentration of vitamin A derivative RA can lead to disruptions in brain development

Using cutting-edge imaging technology, University of California, Irvine biologists have determined that uncontrolled fluctuations (known at "noise) in the concentration of the vitamin A derivative Retinoic acid (RA) can lead to disruptions in brain organization during development.

18 Apr 2016

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

One in 5,000 babies is born missing a small amount of genetic material from the tip of chromosome 1, a region called 1p36. Missing genes in the 1p36 region is a relatively common cause of intellectual disability.

18 Apr 2016

False-positive mammogram results may have varied effects on subsequent screening behavior of women

Depending on when they received their last mammogram, women who receive a false-positive result are more or less likely to get screened at recommended intervals, according to preliminary findings from a University of North Carolina Comprehensive Cancer Center study.

18 Apr 2016

Research finds high prevalence of smoking, low cessation rates in people with schizophrenia

Smoking addiction in schizophrenia can be explained by significantly increased activation of the ventro-medial prefrontal cortex (vmPFC), a region involved in the brain reward system. These new data, the result of a study by researchers at the Institut universitaire en santé mentale de Montréal and the University of Montreal confirms the tendency to smoke and low smoking cessation rates of people with schizophrenia.

18 Apr 2016

Mouse model can help identify new, more effective melanoma-preventing agents

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet-B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. This data suggest that the mouse model can be used to identify new, more effective melanoma-preventing agents, according to principal investigator Christin Burd, PhD.

18 Apr 2016

African sleeping sickness parasite has defence mechanism against potential pharmaceuticals

Researchers from Umea University in Sweden have discovered that the single-celled parasite causing African sleeping sickness has a defence mechanism against potential pharmaceuticals under development against the disease. The deadly parasite has an enzyme that can cleave and hence disarm adenosine analogue pharmaceuticals. This according to a study recently published in the Journal of Biological Chemistry.

18 Apr 2016

Green vegetation near homes plays important role in reducing mortality

Women live longer in areas with more green vegetation, according to new research funded by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health. Women with the highest levels of vegetation, or greenness, near their homes had a 12 percent lower death rate compared to women with the lowest levels of vegetation near their homes. The results were published Apr. 14, 2016 in the journal Environmental Health Perspectives.

18 Apr 2016

South Dakota researchers aim to improve tobacco-free policies in health-care facilities

Health-care facilities being tobacco-free seems like a natural fit, but it's far more complicated than it might seem.

18 Apr 2016

Report highlights parlous state of British children's teeth

The Local Government Association has today published a report that states that around 100 children and teenagers a day are being admitted to hospital for surgery to remove rotten teeth.

18 Apr 2016

Survivin inhibitor with chemotherapy provides therapeutic advantage for Rb cells, tumors

Researchers at The Saban Research Institute of Children's Hospital Los Angeles (CHLA) have demonstrated that targeting survivin - a protein that inhibits apoptosis or cell death - enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumor of the eye in children.

18 Apr 2016

Scientists develop graphene-based sensor that can detect harmful air pollution in home

Scientists from the University of Southampton, in partnership with the Japan Advanced Institute of Science and Technology, have developed a graphene-based sensor and switch that can detect harmful air pollution in the home with very low power consumption.

18 Apr 2016

Study shows Americans live longer, but in poor health

Americans are living longer but in poorer health, according to a new study. The USC-led study examined life expectancy trends and disability rates in a 40-year period, from 1970 to 2010. The analysis of U.S. vital statistics found that the average total lifespan increased for men and women in those 40 years, but so did the proportion of time spent living with a disability.

18 Apr 2016

Computer-based cognitive remediation at home can improve cognitive symptoms in MS patients

Cognitive impairment is one of the core symptoms of multiple sclerosis (MS) -- and one of its most troubling concerns for many people with the condition. Now, a new study from NYU Langone Medical Center may provide hope for symptomatic relief for some of the cognitive issues associated with the neurological disease.

18 Apr 2016

MGH-led study confirms safety of allergy immunotherapy

A team of Massachusetts General Hospital investigators has found no evidence of infections related to administration of allergy immunotherapy, the common practice of injecting minimal quantities of allergens beneath the skin to reduce the allergic response.

18 Apr 2016

Study indicates mRS is poorly suited to evaluate, report quality of neuro-surgery

Surgery has become a volatile field during the past few years, with study after study challenging prevailing treatment practices. For example, surgical treatment of acute appendicitis and arthroscopic surgery on degenerative knees have been called into question by recent research results reached by Finnish researchers.

18 Apr 2016

Scientists identify unique memory suppressor gene that could provide clues for new Alzheimer’s disease treatments

While research has identified hundreds of genes required for normal memory formation, genes that suppress memory are of special interest because they offer insights into how the brain prioritizes and manages all of the information, including memories, that it takes in every day.

18 Apr 2016

Study supports screening for HLA-B*5801 gene variant in Asian, black patients with gout

A multi-institutional study led by a Massachusetts General Hospital investigator finds significant racial disparities in the risk that patients being treated for gout will develop a serious, sometimes life-threatening adverse reaction to the most commonly prescribed medication. The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

16 Apr 2016

Flat adenomas may warrant keeping closer eye on patients at risk for colorectal cancer

Being on the lookout for certain features of polyps may help physicians keep a closer eye on patients at risk for colorectal cancer.

16 Apr 2016

Medical Research News

UAB lab to offer new tests for genetic diseases using next-generation sequencing

Existing cancer drugs may be able to help people with enlarged heart cells

Noise in concentration of vitamin A derivative RA can lead to disruptions in brain development

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

False-positive mammogram results may have varied effects on subsequent screening behavior of women

Research finds high prevalence of smoking, low cessation rates in people with schizophrenia

Mouse model can help identify new, more effective melanoma-preventing agents

African sleeping sickness parasite has defence mechanism against potential pharmaceuticals

Green vegetation near homes plays important role in reducing mortality

South Dakota researchers aim to improve tobacco-free policies in health-care facilities

Report highlights parlous state of British children's teeth

Survivin inhibitor with chemotherapy provides therapeutic advantage for Rb cells, tumors

Scientists develop graphene-based sensor that can detect harmful air pollution in home

Study shows Americans live longer, but in poor health

Computer-based cognitive remediation at home can improve cognitive symptoms in MS patients

MGH-led study confirms safety of allergy immunotherapy

Study indicates mRS is poorly suited to evaluate, report quality of neuro-surgery

Scientists identify unique memory suppressor gene that could provide clues for new Alzheimer’s disease treatments

Study supports screening for HLA-B*5801 gene variant in Asian, black patients with gout

Flat adenomas may warrant keeping closer eye on patients at risk for colorectal cancer

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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