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Jacobsen syndrome linked to autism, find UCSD and SDSU researchers

A rare genetic disorder known as Jacobsen syndrome has been linked with autism, according to a recent joint investigation by researchers at San Diego State University and the University of California, San Diego. In addition to suggesting better treatment options for people with Jacobsen syndrome, the finding also offers more clues into the genetic underpinnings of autism.

18 Sep 2014

Study uncovers new genetic risk factor for deadly skin cancer

Buffers that guard against damage to the ends of chromosomes could hold the key to a better understanding of malignant melanoma - the deadliest form of skin cancer - according to new research from the University of Leeds.

18 Sep 2014

New study analyzes how changes in diet and lifestyle can contribute to healthy aging

A new, first-of-its-kind research study was announced today that will analyze how changes in diet and lifestyle can impact long-term wellness and contribute to healthy aging.

18 Sep 2014

Disrupting cancer regulator MYC: an interview with Professor Kim Janda

MYC is an oncogenic member of the basic helix-loop-helix-leucine zipper transcription factor family. In its monomeric form, MYC’s tertiary structure is intrinsically disordered and the protein is transcriptionally inactive.

17 Sep 2014

Urgency breeds aggression in schizophrenia patients

Increased urgency is a major contributor to aggression in patients with schizophrenia, suggests research published in The American Journal of Psychiatry.

17 Sep 2014

Recovery-focused CBT aids bipolar patients

Cognitive behavioural therapy that is focused broadly on patients’ recovery may be an effective intervention for patients with recent-onset bipolar disorder, a pilot randomised trial indicates.

17 Sep 2014

Ramucirumab effective second-line option for NSCLC

The monoclonal antibody ramucirumab, when added to second-line docetaxel, significantly improves the overall survival of patients with stage IV non-small-cell lung cancer, show the findings of the REVEL trial.

17 Sep 2014

Survival benefits with erlotinib plus bevacizumab in EGFR-Mutated NSCLC

Combining erlotinib with bevacizumab could prolong progression-free survival in patients being treated for epidermal growth factor receptor-mutated non-small-cell lung cancer, phase II trial results suggest.

17 Sep 2014

Urinary nerve growth factor shows diagnostic value

Urinary nerve growth factor could be a useful biomarker for the diagnosis of overactive bladder and a predictive biomarker to help guide treatment, Chinese researchers believe.

17 Sep 2014

Sacral neuromodulation augments efficacy of antimuscarinics in OAB

The addition of sacral neuromodulation to antimuscarinic pharmacotherapy offers significant benefits over antimuscarinics alone in the treatment of women with idiopathic overactive bladder, study findings show.

17 Sep 2014

Fat mass contributes to musculoskeletal pain risk

People with high fat mass could be at an increased risk of musculoskeletal pain, say researchers.

17 Sep 2014

Catecholamine polymorphism influences opioid use

The catechol-O-methyltransferase rs4680 single nucleotide polymorphism could affect postoperative opioid consumption, study findings show.

17 Sep 2014

S. pneumoniae drug susceptibility tracked in Japan

A 12-year survey of the antimicrobial susceptibility of Streptococcus pneumoniae isolates in Miyagi Prefecture in Japan has identified important changes, including improved susceptibility to β-lactam antibiotics.

17 Sep 2014

S-1 plus radiotherapy shows promise in elderly NSCLC patients

Concurrent administration of S-1 chemotherapy and radiotherapy has a favourable impact on survival in elderly patients with locally advanced non-small-cell lung cancer, a phase II trial has found.

17 Sep 2014

Age confounds relationship between ambulatory and office BP

The relationship between ambulatory and office blood pressure varies with age, with the likelihood of white-coat hypertension increasing as people get older, a study shows.

17 Sep 2014

Lobectomy and segmentectomy have similar efficacy in stage I NSCLC

Lobectomy and anatomic segmentectomy appear to offer similar perioperative and oncological outcomes in patients with stage I non-small-cell lung cancer, analysis suggests.

17 Sep 2014

Life events may worsen bipolar I disorder course

A study suggests that negative life events may trigger depressive episodes in patients with bipolar I disorder.

17 Sep 2014

Reading deficits in schizophrenia contribute to underachievement

People with schizophrenia display severe deficits in reading ability that are not captured in current routine clinical assessments, a study by US researchers indicates.

17 Sep 2014

Childhood psychiatric disorders linked to schizophrenia risk

Having a childhood psychiatric disorder increases people’s likelihood of being later diagnosed with schizophrenia, research shows.

17 Sep 2014

Cyclothymic temperament linked to suicidality

The presence of a cyclothymic temperament in inpatients with bipolar disorder may indicate a high likelihood of hopelessness and suicidality, report researchers.

17 Sep 2014