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Researchers partner to help personalize cancer care

Researchers at the University of Iowa College of Dentistry are partnering with a private company to develop computer simulations that can help personalize cancer care by predicting how a patient will respond to a drug treatment.

7 Dec 2015

Gene therapy can restore immune systems of children and young adults with SCID-X1

Gene therapy can safely rebuild the immune systems of older children and young adults with X-linked severe combined immunodeficiency (SCID-X1), a rare inherited disorder that primarily affects males, scientists from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, have found.

7 Dec 2015

Research reveals genetic variants linked to treatment-related complications in children with blood diseases

Research to be presented today at the 57th American Society of Hematology Annual Meeting and Exposition reveals genetic variants that are associated with disease severity and treatment-related complications in children with blood diseases.

7 Dec 2015

Genetic variations associated with increased risk for osteonecrosis in young ALL patients

Variations in genes involved in normal bone development are associated with an 8- to 15-fold increased risk for osteonecrosis in young patients with acute lymphoblastic leukemia (ALL), according to research led by St. Jude Children's Research Hospital and Children's Oncology Group investigators.

7 Dec 2015

Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

New research adds to a growing body of evidence that gene therapy, an experimental technique that involves correcting or replacing a person's mutated or malfunctioning genes, may improve health outcomes for patients with inherited bleeding and immune disorders as well as some forms of blood cancer.

7 Dec 2015

Anthracycline-based breast cancer chemotherapy linked to neurotoxicity

Breast cancer patients treated with anthracycline-based chemotherapy regimens may be at greater risk of neurocognitive problems than those given nonanthracycline regimens, indicate findings.

4 Dec 2015

Predictors of cerebral cavernous malformation outcomes pinpointed

A meta-analysis of individual patient data has identified risk factors for intracerebral haemorrhage in patients with cerebral cavernous malformations.

4 Dec 2015

Infant death risk higher for mothers who gain weight gain between pregnancies

An analysis of pregnancies recorded on the Swedish Medical Birth Register indicates that the risk of a baby dying in its first year of life is greater among mothers who gain weight between their first and second pregnancies compared with women who do not gain weight.

3 Dec 2015

False-positive mammograms may indicate future breast cancer risk

Women who receive a false-positive mammogram result may be at greater risk of developing breast cancer for up to ten years afterwards, report researchers from the US.

3 Dec 2015

HBsAg may persist in chronic HBV patients beyond seroclearance

The use of a highly sensitive assay for the detection of hepatitis B surface antigen suggests that HBsAg negativity as evaluated by the conventional test may not be indicative of seroclearance in patients with chronic hepatitis B virus infection.

3 Dec 2015

Combining medications may increase HBsAg loss in HBV patients

Combining tenofovir disoproxil fumarate with pegylated interferon alfa-2a may improve the chances of hepatitis B surface antigen loss in patients with hepatitis B virus infection, suggests a randomised trial.

3 Dec 2015

Phase II study hints at oestriol effect in multiple sclerosis

Oestriol, given in combination with glatiramer acetate, may reduce the risk of relapse in women with relapsing–remitting multiple sclerosis, suggest findings from a phase II trial.

3 Dec 2015

Methylphenidate for ADHD requires ‘careful monitoring’

A Cochrane review of evidence to date has cast uncertainty over the magnitude of benefit children with attention deficit/hyperactivity gain by taking methylphenidate.

3 Dec 2015

Olympus CKX53 microscope: Advancing cell cultivation

Streamlining the cell culture workflow in a range of application areas, Olympus’ renowned optical expertise has given rise to the new CKX53 microscope including a novel inversion phase contrast (IVC) imaging technique

From Evident Corporation - Life Sciences 3 Dec 2015

Small-vessel disease has uncertain impact on large-vessel stenosis outcomes

Research shows that small-vessel disease is common among patients with intracranial arterial stenosis, but that its effect on stroke risk cannot be separated from the effect of associated risk factors.

2 Dec 2015

Preventable comorbidities common in cerebral palsy patients

Medical comorbidities are common in patients with cerebral palsy and may impact on their mobility, report researchers.

2 Dec 2015

Potential for chemotherapy-free standard of care in advanced mantle cell lymphoma

The combination of ibrutinib and rituximab shows activity in patients with relapsed or refractory mantle cell lymphoma, suggests research published in The Lancet Oncology.

2 Dec 2015

Our appetite is dictated by gut bacteria

Bacteria in our stomachs might be deciding when we’ve eaten enough and switch off appetite, according to new research.

2 Dec 2015

EKF biomarker identifies likely development of Diabetic Nephropathy

EKF, announces new data presented in support of soluble Tumour Necrosis Factor Receptor 1 as a biomarker to predict progression of Diabetic Nephropathy.

From EKF Diagnostics 2 Dec 2015

Bacteriophage therapy: an alternative to antibiotics? An interview Professor Clokie

A phage is a virus that infects a bacterium. People often get very confused about what the difference is between a virus and a bacterium. A virus, like a bacterium, is also a microorganism, but unlike bacteria, it needs to have a host to be able to replicate and propagate.

2 Dec 2015