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New study reveals how genetic defect may make people more susceptible to developing melanoma

A new study by University of Kentucky researchers shows how a genetic defect in a specific hormonal pathway may make people more susceptible to developing melanoma, the deadliest type of skin cancer.

16 Jul 2014

Cryptococcus gattii evolves as it spreads to temperate climates

Cryptococcus gattii, a virulent fungus that has invaded the Pacific Northwest is highly adaptive and warrants global "public health vigilance," according to a study by an international team led by the Translational Genomics Research Institute.

16 Jul 2014

Urgency Questionnaire validated for use in overactive bladder

The symptom of urinary urgency experienced by people with overactive bladder is a pathological sensation distinctive from the normal urge to void, US researchers believe.

15 Jul 2014

LUTS questionnaire validated in Japanese population

The Core Lower Urinary Symptom Score questionnaire has been validated for use in Japanese patients and may be useful as a screening tool in both clinical or research settings, researchers report.

15 Jul 2014

Embolisation of abnormal neovessels relieves osteoarthritic knee pain

Transcatheter arterial embolisation relieves knee pain in patients with moderate osteoarthritis who are resistant to pharmacological pain management, research suggests.

15 Jul 2014

Healthy lifestyle helps hard-to-treat hypertensive patients

Maintaining a healthy lifestyle can prevent cardiovascular events even among patients with apparent treatment-resistant hypertension, say researchers.

15 Jul 2014

Novel oxygen uptake parameter aids idiopathic PAH evaluation

Oxygen uptake efficiency plateau, measured during the cardiopulmonary exercise test, offers a novel method for evaluating gas exchange abnormalities in patients with idiopathic pulmonary hypertension, Chinese researchers report.

15 Jul 2014

Education boosts glycaemic control after diabetes diagnosis

Attending a brief diabetes education programme enhances the glycaemic control achieved by patients newly diagnosed, research suggests.

15 Jul 2014

CHEST guideline released for PAH

An updated CHEST guideline for treating pulmonary arterial hypertension provides some evidence-based recommendations but also highlights many evidence gaps.

15 Jul 2014

Inflammatory shift in long-standing bipolar disorder

Patients with chronic bipolar disorder, but not those with schizophrenia, have a shift towards an M1 rather than an M2 macrophage response, research suggests.

15 Jul 2014

Motivational impairment could be early target for psychosis risk

Research suggests that motivational impairment may be present before psychosis onset but does not worsen over the course of the illness.

15 Jul 2014

Very-late-onset schizophrenia linked to particularly high mortality risk

Patients with very-late-onset schizophrenia-like psychosis have an increased risk of death compared with both the general population and patients with schizophrenia diagnosed earlier in life, Finnish study findings indicate.

15 Jul 2014

Openness predicts cognitive function in bipolar disorder

The degree of Openness to Experiences reported by patients with bipolar disorder could be used to identify potential candidates requiring more comprehensive cognitive assessments, US researchers report.

15 Jul 2014

Urge incontinence therapy may relieve stress incontinence

Anticholinergic medication appears to be effective as a treatment for stress and mixed urinary incontinence, results of a small clinical trial indicate.

15 Jul 2014

Nocturia affects one in three premenopausal women

Nocturia affects around one-third of women of reproductive age, a survey has found, highlighting that the condition is not confined to elderly individuals.

15 Jul 2014

Japanese SF-MPQ valid for neuropathic and non-neuropathic pain

Researchers have developed a Japanese translated version of the Short-Form McGill Pain Questionnaire-2 that shows good reliability and validity for discriminating between chronic neuropathic and non-neuropathic pain.

15 Jul 2014

Localised inflammation found in eosinophilic otitis media

Antigen-specific immunoglobulin E is produced locally in the middle ear mucosa of patients with eosinophilic otitis media, clinical research indicates.

15 Jul 2014

Night-time BP variability improves vascular risk prediction

Measuring night-time variability in the blood pressure of patients with hypertension may help to predict their risk of having a cardiovascular event, show data from an international study.

15 Jul 2014

‘No convincing evidence’ for zinc supplements to prevent otitis media

There is no convincing evidence that zinc supplements reduce the risk of otitis media in children or adults, say the authors of an updated Cochrane review.

15 Jul 2014

PAH disease burden ‘significant’

Patients with newly diagnosed pulmonary arterial hypertension have a substantial burden of disease, with more than half hospitalised during the first 3 years post-diagnosis, research shows.

15 Jul 2014