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LongROAD project launched to improve safety and mobility needs of older adults

In the coming decades, the population of older adults in the United States will reach unprecedented numbers. By the year 2029, more than one in five Americans will be over the age of 65. And most of them will continue driving. To understand their safety and mobility needs, the AAA Foundation for Traffic Safety has launched a five-year, $12 million Longitudinal Research on Aging Drivers (LongROAD) project with Columbia University's Mailman School of Public Health and six other institutions.

13 Jan 2015

New study finds prevalence of secondhand smoke exposure among teens who have never smoked

Many teens who have never smoked are being exposed to the health dangers of tobacco. A new study by the University of Texas Medical Branch at Galveston, in collaboration with East Tennessee State University, the Indian Institute of Technology and the World Health Organization Regional Office for Africa, estimated the prevalence of secondhand smoke exposure worldwide among teens who had never smoked, and found that one third of those teens are exposed to secondhand smoke inside the home.

13 Jan 2015

Scientists find that blocking hormone reduces stress-induced infertility in female rats

University of California, Berkeley, scientists have discovered that chronic stress activates a hormone that reduces fertility long after the stress has ended, and that blocking this hormone returns female reproductive behavior to normal.

13 Jan 2015

TSRI researchers identify enzyme that produces inflammatory lipid molecules in the brain

A team led by scientists at The Scripps Research Institute has identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited neurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that inhibit this enzyme.

13 Jan 2015

How quickly smokers metabolise nicotine may point to best quitting method

The success of different smoking cessation treatments could be predicted by how quickly smokers break down (metabolise) nicotine in their bodies, according to new research published in The Lancet Respiratory Medicine journal.

13 Jan 2015

CML mouse model reveals previously unreported facets of disease

A humanised murine model of chronic phase chronic myeloid leukaemia, developed by a Swedish research team, provides insight into previously unexplored characteristics of the disease.

12 Jan 2015

EGFR mutations, ALK translocations not mutually exclusive in NSCLC

Researchers from the Republic of Korea have found that epidermal growth factor receptor mutations and anaplastic lymphoma kinase translocations can occur concomitantly in a proportion of patients with non-small-cell lung cancer.

12 Jan 2015

PF-114 shows promise in therapy-resistant CML, Ph-positive ALL

PF-114, a selective tyrosine kinase inhibitor, is active against native and mutated forms of the BCR–ABL oncogene in Philadelphia chromosome-positive leukaemias, according to preclinical cellular and in vivo results published in Leukemia.

12 Jan 2015

Blast phase characteristics differ in TKI-, non-TKI–treated CML patients

Features of the blast phase, such as blast cell morphology and accompanying cytogenetic changes, vary between chronic myeloid leukaemia patients who received tyrosine kinase inhibitor therapy and those treated in the pre-TKI era, research shows.

12 Jan 2015

New way to measure upper extremity movement in muscular dystrophy patients

Researchers at Nationwide Children's Hospital have developed a way to measure upper extremity movement in patients with muscular dystrophy using interactive video game technology. Their hope is to expand inclusion criteria for clinical trials to incorporate patients using wheelchairs.

12 Jan 2015

Researchers find mechanism that leads to resistance to targeted therapy in melanoma patients

Moffitt Cancer Center researchers have discovered a mechanism that leads to resistance to targeted therapy in melanoma patients and are investigating strategies to counteract it. Targeted biological therapy can reduce toxicity and improve outcomes for many cancer patients, when compared to the adverse effects of standard chemotherapeutic drugs.

12 Jan 2015

Study demonstrates that pelvic floor muscle training improves erectile function

Preliminary results of a four-month clinical trial offer hope for the thousands of baby boomer men turning 50 every minute, with nearly 6-in-10 of them experiencing erectile dysfunction. Proving pelvic floor exercise can help turn back the clock on sexual decline, the study demonstrates that weighted resistance training improves erectile function in both healthy men and those with erectile dysfunction.

12 Jan 2015

State and federal prisoners not receiving adequate mental health care

A significant portion of state and federal prisoners are not receiving treatment for mental health conditions, according to research by The University of Texas Health Science Center at Houston School of Public Health.

12 Jan 2015

New project explores role of gut microbiota in preventing diet- and brain-related diseases

A new project comprising thirty organisations from fifteen countries has started working together to study the microorganisms in our intestines and the role they play in health, well-being, and how they can help prevent diet- and brain-related diseases.

12 Jan 2015

Virginia Tech scientists plan to design virus to switch wound-healing drug into cancer fighter

At the Virginia Tech Carilion Research Institute, three scientists are planning to create a virus capable of destroying brain cancer.

12 Jan 2015

New insight into molecular mechanism of ancient evolutionary enzyme

A team led by structural biologists at The Scripps Research Institute has taken a big step toward understanding the intricate molecular mechanism of a metabolic enzyme produced in most forms of life on Earth.

12 Jan 2015

Research findings may lead to new therapeutic target for AML treatment

A study by the Cancer Science Institute of Singapore at the National University of Singapore has found new interactions between two molecules involved in acute myeloid leukaemia (AML), STAT3 and PRL-3, which may offer a new therapeutic target for cancer treatment.

12 Jan 2015

Medical Research News

LongROAD project launched to improve safety and mobility needs of older adults

New study finds prevalence of secondhand smoke exposure among teens who have never smoked

Scientists find that blocking hormone reduces stress-induced infertility in female rats

TSRI researchers identify enzyme that produces inflammatory lipid molecules in the brain

How quickly smokers metabolise nicotine may point to best quitting method

CML mouse model reveals previously unreported facets of disease

EGFR mutations, ALK translocations not mutually exclusive in NSCLC

PF-114 shows promise in therapy-resistant CML, Ph-positive ALL

Blast phase characteristics differ in TKI-, non-TKI–treated CML patients

New way to measure upper extremity movement in muscular dystrophy patients

Researchers find mechanism that leads to resistance to targeted therapy in melanoma patients

Study demonstrates that pelvic floor muscle training improves erectile function

State and federal prisoners not receiving adequate mental health care

New project explores role of gut microbiota in preventing diet- and brain-related diseases

Virginia Tech scientists plan to design virus to switch wound-healing drug into cancer fighter

New insight into molecular mechanism of ancient evolutionary enzyme

Research findings may lead to new therapeutic target for AML treatment

Circumcised boys more likely to develop autism spectrum disorder

ULB researchers uncover new mechanism involved in tumour initiation, growth in SCC

Pellino3 protein may prevent obesity-driven diabetes, find Maynooth University scientists

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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