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New approach to knocking out parasite's genes

Plasmodium falciparum, the parasite that causes malaria, has proven notoriously resistant to scientists' efforts to study its genetics.

12 Aug 2014

Novogen receives funding support to commence studies in muscular dystrophy

The Australian biotechnology company, Novogen Limited today announced receipt of funding from the FSHD Global Research Foundation as part of the Company’s efforts to find effective treatments for a range of musculo-degenerative diseases including facioscapulohumeral dystrophy (FSHD).

11 Aug 2014

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

How much is currently known about what happens in the developing brain that puts people at risk of schizophrenia?

11 Aug 2014

Nigral neuronal loss and α-synuclein pathology scrutinised in PD

The severity of neurodegeneration and local burden of α-synuclein are closely coupled during disease progression in Parkinson’s disease, a post-mortem study has found.

11 Aug 2014

In vivo dopaminergic imaging strongly correlates with brain pathology

Striatal dopamine transporter binding, assessed using single-photon emission computed tomography, is strongly correlated with substantia nigra cell counts assessed at postmortem, say the authors of a study.

11 Aug 2014

$Sacral magnetic stimulation effective in refractory stress incontinence$

Sacral magnetic stimulation effective in refractory stress incontinence

Sacral magnetic stimulation may be an effective treatment for stress urinary incontinence in women whose symptoms are refractory to standard therapies, a clinical trial suggests.

11 Aug 2014

Opioid compliance checklist shows promise for chronic pain management

Researchers have developed a brief and simple checklist that clinicians can use to monitor opioid adherence among people with chronic pain.

11 Aug 2014

Mucosal lymphoid cells key to S. pneumoniae defence

Type 3 innate lymphoid cells in the lung mucosa are activated early in the course of infection with Streptococcus pneumoniae and are a major source of interleukin-22 production, research reveals.

11 Aug 2014

First-line sunitinib superior to everolimus for metastatic RCC

Results for the RECORD-3 trial support the current strategy of first-line sunitinib followed by second-line everolimus for the treatment of patients with metastatic renal cell carcinoma.

11 Aug 2014

Midlife hypertension link to later-life cognitive decline strengthened

Analysis of the Atherosclerosis Risk in Communities study cohort supports an association between elevated blood pressure in midlife and increased cognitive decline in older age.

11 Aug 2014

Baseline characteristics influence Parkinson’s disease course

Motor progression in Parkinson’s disease is non-linear and occurs in three distinct phases, all of which are affected by baseline variables such as gender, age at diagnosis, disease subtype, cognitive status and motor score, study findings indicate.

11 Aug 2014

Researchers discover how immunosensory system attacks viruses on a molecular level

Our immunosensory system detects virus such as influenza via specific characteristics of viral ribonucleic acid. Previously, it was unclear how the immune system prevents viruses from simply donning molecular camouflage in order to escape detection.

11 Aug 2014

CRI researchers identify gene linked to several childhood cancers

Researchers at the Children-s Medical Center Research Institute at UT Southwestern have identified a gene that contributes to the development of several childhood cancers, in a study conducted with mice designed to model the cancers.

11 Aug 2014

GW researcher awarded grant to develop a model system to study PN infection

According to a recent World Health Organization report of the leading causes of death worldwide, one-third of all deaths are due to infectious and parasitic diseases. There are currently no vaccines for parasitic nematode (PN), or worm infections in humans, and development of new drugs and vaccines will stall until researchers have a better understanding of PN biology.

11 Aug 2014

Antimalarial agent chloroquine normalizes abnormal tumor blood vessels

A recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. This blood vessel normalization results in an increased barrier function on the one hand -- thereby blocking cancer cell dissemination and metastasis -- and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

11 Aug 2014

ALS Association awards 21 new research grants to find cure for amyotrophic lateral sclerosis

The ALS Association announced today that it has awarded 21 new research grants totaling nearly $3.5 million to find treatments and a cure for amyotrophic lateral sclerosis (ALS). The grants were awarded to scientists from laboratories located in nine different states in the United States as well as from the United Kingdom, France, Canada, Switzerland, Israel and Australia.

11 Aug 2014

New method could make cashews safer for people with allergies

For the millions of adults and children in the U.S. who have to shun nuts to avoid an allergic reaction, help could be on the way. Scientists are now developing a method to process cashews - and potentially other nuts - that could make them safer to eat for people who are allergic to them.

11 Aug 2014