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Lack of SIRT1 protein in the liver leads to lower levels of liver FGF21

A new study led by Boston University School of Medicine demonstrates that the abnormal metabolism linked to obesity could be regulated in part by the interaction of two metabolic regulators, called the NAD-dependent deacetylase SIRT1 and fibroblast growth factor 21 (FGF21). Using experimental models, the researchers found that a lack of SIRT1 protein in the liver led to lower levels of a liver secreted protein FGF21, which resulted in an increased likelihood of developing fatty liver disease and obesity.

22 Jan 2014

Childhood bereavement contributes to future psychosis risk

The death of a close family member during childhood is associated with an increased risk for future psychosis, research shows.

22 Jan 2014

Outcome good for patients with dual alcohol use and affective disorders

Alcohol use disorders in patients with depression or bipolar disorder can be successfully treated with intervention and follow-up, say researchers.

22 Jan 2014

Overdiagnosis concerns raised for CT lung cancer screening

People participating in any future computed tomography lung cancer screening program would face a significant risk for overdiagnosis, US researchers caution in JAMA Internal Medicine.

22 Jan 2014

Blood methylome offers clues to schizophrenia

Researchers show that a methylome-wide association study of the blood can provide a glimpse of past environmental insults that may contribute to the development of schizophrenia.

22 Jan 2014

Schizophrenia cognition tool promising in bipolar disorder patients

The Brief Assessment of Cognition in Schizophrenia may be an appropriate tool for measuring cognition in elderly patients with bipolar disorder, a pilot study suggests.

22 Jan 2014

High-protein diet increases chance of developing kidney stones, other renal diseases

High-protein diets, like the popular Dr. Dukan diet, increase the long-term risk of developing kidney disease and have a negative effect on renal urinary and morphological markers. What's more, they may promote serious pathologies like nephrolithiasis (calcium kidney stones) because they drastically reduce urinary citrate (an inhibitor of calcium salt crystallization) and urinary pH, and increase urinary calcium (to compensate for the metabolic acidity caused by excess protein).

22 Jan 2014

Research under way to develop new techniques for detecting diabetic retinopathy

Research is under way to develop new techniques for detecting diabetic retinopathy at early onset with the hope of improving prevention and treatment of this major cause of blindness.

22 Jan 2014

Long-term exposure to particulate matter linked with increased risk for heart attack

Long-term exposure to particulate matter is associated with an increased risk for heart attack. Moreover, this association can already be observed in levels of particulate exposure below the current specified European limit values.

22 Jan 2014

Study reports that being overweight makes children less active

A new study from the University of Copenhagen's OPUS Research Centre reports that being overweight makes children less active. The findings underscore that parents of overweight children have an obligation to keep their children active, as physical activity is vital for the general health of all children. The study also shows that slender children do not become overweight due to a lack of activity.

22 Jan 2014

Girls treated for Hodgkin's disease during adolescence acquire risk of developing breast cancer

Girls treated for Hodgkin's disease during adolescence acquire a considerable risk of developing breast cancer, as shown by an observational study published in the current issue of Deutsches Ärzteblatt International.

22 Jan 2014

Scientists identify specific enzyme essential for brain development

Scientists from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna have identified a specific enzyme, histone deacetylase 2 (HDAC2), as essential for brain development. The findings published in Development are important to advance the development of new drugs to treat neurological diseases.

22 Jan 2014

Increasing number of children are treated in U.S. EDs for head injuries

Although a voluntary shopping cart safety standard was implemented in the United States in 2004, the overall number and rate of injuries to children associated with shopping carts have not decreased. In fact, the number and rate of concussions/closed head injuries have continued to climb, according to a new study.

22 Jan 2014

Bread can now become daily sources of vitamin D when baked with Lallemand's baker's yeast

Lallemand is pleased to announce that the European Food Safety Authority (EFSA) has issued a positive opinion on the use of Vitamin D2 rich baker's yeast (Saccharomyces Cerevisiae) in yeast-leavened bread, rolls, fine bakery wares and food supplements.

22 Jan 2014

Researchers develop web-based course to prevent excessive weight gain in young adults

The transition from adolescence to adulthood presents individuals with many challenges. Perhaps none are as important as those relating to health and quality of life. Young adults, aged 18 to 25, are at high risk for weight gain.

22 Jan 2014

Study ultimately could lead to development of screening test for diagnosing bladder cancer

Findings from a Loyola University Medical Center study ultimately could lead to tests to screen for and diagnose bladder cancer.

22 Jan 2014

People who are less patient tend to move eyes with greater speed, say researchers

Using a simple study of eye movements, Johns Hopkins scientists report evidence that people who are less patient tend to move their eyes with greater speed. The findings, the researchers say, suggest that the weight people give to the passage of time may be a trait consistently used throughout their brains, affecting the speed with which they make movements, as well as the way they make certain decisions.

22 Jan 2014

UT Southwestern' faculty receives Stanley J. Korsmeyer Award for contributions to understanding of autophagy

Dr. Beth Levine, a Howard Hughes Medical Institute Investigator and Director of the Center for Autophagy Research at UT Southwestern Medical Center, has received the 2014 Stanley J. Korsmeyer Award from the American Society for Clinical Investigation.

22 Jan 2014

Basic hospice strategies can make last days of dying inpatients more comfortable and dignified

There is much value in training hospital and nursing home staff in the basics of palliative care to make the last days of a dying patient's life as comfortable and dignified as possible.

22 Jan 2014

ASA's recommendations to help patients avoid unnecessary tests for chronic pain

Not prescribing opioids first or as a long-term therapy for chronic, non-cancer pain and avoiding MRIs, CTs and X-rays for low-back pain are among the tests and treatments identified by ASA that are commonly ordered but not always necessary.

22 Jan 2014

Medical Research News

Lack of SIRT1 protein in the liver leads to lower levels of liver FGF21

Childhood bereavement contributes to future psychosis risk

Outcome good for patients with dual alcohol use and affective disorders

Overdiagnosis concerns raised for CT lung cancer screening

Blood methylome offers clues to schizophrenia

Schizophrenia cognition tool promising in bipolar disorder patients

High-protein diet increases chance of developing kidney stones, other renal diseases

Research under way to develop new techniques for detecting diabetic retinopathy

Long-term exposure to particulate matter linked with increased risk for heart attack

Study reports that being overweight makes children less active

Girls treated for Hodgkin's disease during adolescence acquire risk of developing breast cancer

Scientists identify specific enzyme essential for brain development

Increasing number of children are treated in U.S. EDs for head injuries

Bread can now become daily sources of vitamin D when baked with Lallemand's baker's yeast

Researchers develop web-based course to prevent excessive weight gain in young adults

Study ultimately could lead to development of screening test for diagnosing bladder cancer

People who are less patient tend to move eyes with greater speed, say researchers

UT Southwestern' faculty receives Stanley J. Korsmeyer Award for contributions to understanding of autophagy

Basic hospice strategies can make last days of dying inpatients more comfortable and dignified

ASA's recommendations to help patients avoid unnecessary tests for chronic pain

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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